Metronidazol

Metronidazol
Klinički podaci
Prodajno imeOrvagil, Metronidazol
Drugs.comMonografija
Način primeneOralno, intravaginalno, topikalno
Farmakokinetički podaci
Poluvreme eliminacije6-8 h
Identifikatori
CAS broj443-48-1 ДаY
ATC kodA01AB17 (WHO), P01AB01
PubChemCID 4173
DrugBankDB00916 ДаY
ChemSpider4029 ДаY
ChEBICHEBI:6909 ДаY
ChEMBLCHEMBL137 ДаY
Hemijski podaci
FormulaC6H9N3O3
Molarna masa171,154
  • CC1=NC=C(N1CCO)[N+]([O-])=O
  • InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3 ДаY
  • Key:VAOCPAMSLUNLGC-UHFFFAOYSA-N ДаY
Fizički podaci
Tačka topljenja1.605 °C (2.921 °F)

Metronidazol je organsko jedinjenje, koje sadrži 6 atoma ugljenika i ima molekulsku masu od 171,154 Da.[1][2][3][4][5][6]

Osobine

Osobina Vrednost
Broj akceptora vodonika 4
Broj donora vodonika 1
Broj rotacionih veza 3
Particioni koeficijent[7] (ALogP) -0,3
Rastvorljivost[8] (logS, log(mol/L)) -1,3
Polarna površina[9] (PSA, Å2) 83,9

Reference

  1. ^ Shennan A, Crawshaw S, Briley A, Hawken J, Seed P, Jones G, Poston L (јануар 2006). „A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study.”. BJOG. 113 (1): 65—74. PMID 16398774. doi:10.1111/j.1471-0528.2005.00788.x. 
  2. ^ Lamont, R. F. (март 2005). „Can antibiotics prevent preterm birth--the pro and con debate”. BJOG. 112 (Suppl. 1): 67—73. PMID 15715599. doi:10.1111/j.1471-0528.2005.00589.x. 
  3. ^ Williams CS, Woodcock KR (фебруар 2000). „Do ethanol and metronidazole interact to produce a disulfiram-like reaction? Ann Pharmacother”. The Annals of Pharmacotherapy. 34 (2): 255—7. PMID 10676835. doi:10.1345/aph.19118. 
  4. ^ Visapaa JP, Tillonen JS, Kaihovaara PS, Salaspuro MP (јун 2002). „Lack of disulfiram-like reaction with metronidazole and ethanol. Ann Pharmacother”. The Annals of Pharmacotherapy. 36 (6): 971—4. PMID 12022894. doi:10.1345/aph.1A066. 
  5. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  6. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  7. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  8. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  9. ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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