Norfloksacin
Norfloksacin Prodajno ime Chibroxin, Noroxin, Trizolin Drugs.com Monografija Način primene Oralno Poluvreme eliminacije 3-4 h Izlučivanje Bilijarno, renalno
CAS broj 70458-96-7 Y ATC kod J01MA06 (WHO ), S01 AE02 PubChem CID 4539 DrugBank DB01059 Y ChemSpider 4380 Y KEGG C06687 Y ChEBI CHEBI:100246 Y ChEMBL CHEMBL9 Y Formula C 16 H 18 F N 3 O 3 Molarna masa 319,331
CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(C=C12)N1CCNCC1
InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
Y Key:OGJPXUAPXNRGGI-UHFFFAOYSA-N
Y
Tačka topljenja 227—228 °C (441—442 °F)
Norfloksacin je organsko jedinjenje , koje sadrži 16 atoma ugljenika i ima molekulsku masu od 319,331 Da .[ 1] [ 2] [ 3]
Osobine
Reference
^ Goldstein EJ: Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity. Am J Med. 1987 Jun 26;82(6B):3-17. PMID 3111257
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs” . Nucleic Acids Res . 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682 . doi :10.1093/nar/gkq1126 .
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets” . Nucleic acids research . 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412 . doi :10.1093/nar/gkm958 .
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods” . J. Phys. Chem. A . 102 : 3762—3772. doi :10.1021/jp980230o .
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices” . Chem Inf. Comput. Sci . 41 : 1488—1493. PMID 11749573 . doi :10.1021/ci000392t .
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties” . J. Med. Chem . 43 : 3714—3717. PMID 11020286 . doi :10.1021/jm000942e .
Literatura
Spoljašnje veze
Antifolati (inhibirapurinski metabolizam , i tim putem inhibira DNK i RNK sintezu)
Inhibitori topoizomeraze /hinoloni / (inhibirajuDNK replikaciju )
Anaerobni DNKinhibitori
RNK sinteza
bact(J1p ,w ,n ,m )/virs(J5d ,r ,h )/fung /para(a ,e ,c ,h ,r ),v ,g
Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja) .