CCL24

Hemokin (C-C motiv) ligand 24
Identifikatori
SimbolCCL24
Alt. simboliSCYA24, Ckb-6, MPIF-2, eotaxin-2
Entrez6369
HUGO10623
OMIM602495
PDB1EIG
RefSeqNM_002991
UniProtO00175
Ostali podaci
LokusHromozom 7 q11.23

CCL24, hemokine (C-C motiv) ligand 24, takođe poznat kao mijeloidni progenitor inhibitorni faktor 2 (MPIF-2), ili eozinofilni hemotaksni protein 2 (eotaksin-2), je protein koji je kod ljudi kodiran CCL24 genom.[1] Taj gen je lociran na ljudskom hromozomu 7.[2][3]

Funkcija

CCL24 je mali citokin iz CC hemokin familije. CCL24 interaguje sa hemokinskim receptorom CCR3 i indukuje hemotaksu eozinofila.[4] Ovaj hemokin je takođe snažno hemotaksan za neaktivirane T limfocite, i u manjoj meri privlači neutrofile.[1]

Klinički značaj

Povišeni nivoi eotaksina-2 su promećeni kod pacijenata sa aspirin pogoršanim respiratornim bolestima, kao što je astma. Ljudi kod kojh su nivoi eotaksina-2 u plazmi niži nisu pokazivali tendenciju ka razvijanju aspirin uzrokovane astme.[5]

Reference

  1. ^ а б Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (1997). „Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors”. J. Exp. Med. 185 (7): 1163—72. PMC 2196270 Слободан приступ. PMID 9104803. 
  2. ^ Hillier LW; Fulton RS; Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7”. Nature. 424 (6945): 157—64. PMID 12853948. doi:10.1038/nature01782. 
  3. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  4. ^ White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (1997). „Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils”. J. Leukoc. Biol. 62 (5): 667—75. PMID 9365122. 
  5. ^ Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (2009). „Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease”. Allergy. PMID 19796209. doi:10.1111/j.1398-9995.2009.02158.x. 

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