CCL4

Hemokin (C-C motiv) ligand 4
PDB prikaz baziran na 1hum​.
Dostupne strukture
1hum​, 1hun​, 1je4​, 2ffk​, 2fin​
Identifikatori
Simboli CCL4; SCYA4; ACT2; AT744.1; G-26; LAG1; MGC104418; MGC126025; MGC126026; MIP-1-beta; MIP1B
Vanjski ID OMIM: 182284 MGI: 98261 HomoloGene: 48153 GeneCards: CCL4 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6351 20303
Ensembl ENSG00000129277 ENSMUSG00000018930
UniProt P13236 Q5QNV9
RefSeq (mRNA) NM_002984 NM_013652
RefSeq (protein) NP_002975 NP_038680
Lokacija (UCSC) Chr 17:
31.46 - 31.46 Mb		 Chr 11:
83.48 - 83.48 Mb
PubMed pretraga [1] [2]

CCL4, hemokin (C-C motiv) ligand 4, je protein koji je kod ljudi kodiran CCL4 genom.[1][2]

Funkcija

CCL4 je CC chemokin koji je specifičan za CCR5 receptore. On je hemoatraktant za NK ćelije, monocite i niz drugih imunskih ćelija.[3]

CCL4 je značajan HIV-supresujući faktor koji proizvode CD8+ T ćelije.[4] Perforin memorijske CD8+ T ćelije normalno sintetišu MIP-1-beta.[5]

Interakcije

Za CCL4 je bilo pokazano da interaguje sa CCL3.[6]

Vidi još

Reference

  1. ^ Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (1990). „Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q”. Nucleic Acids Res. 18 (11): 3261—70. PMC 330932 Слободан приступ. PMID 1972563. doi:10.1093/nar/18.11.3261. 
  2. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  3. ^ Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (2001). „B cells and professional APCs recruit regulatory T cells via CCL4”. Nat. Immunol. 2 (12): 1126—32. PMID 11702067. doi:10.1038/ni735. 
  4. ^ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (1995). „Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells”. Science (journal). 270 (5243): 1811—5. PMID 8525373. 
  5. ^ Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (2001). „Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta”. Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9283—8. PMC 55412 Слободан приступ. PMID 11470920. doi:10.1073/pnas.161298998. 
  6. ^ Guan, E; Wang J; Norcross M A (2001). „Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer”. J. Biol. Chem. United States. 276 (15): 12404—9. ISSN 0021-9258. PMID 11278300. doi:10.1074/jbc.M006327200. 

Literatura

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