Neurotrofni moždani faktor

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Neurotrofni moždani faktor

PDB prikaz baziran na 1bnd[1].
Dostupne strukture
1B8M, 1BND
Identifikatori
SimboliBDNF; ANON2; BULN2
Vanjski IDOMIM: 113505 MGI: 88145 HomoloGene: 7245 GeneCards: BDNF Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez62712064
EnsemblENSG00000176697ENSMUSG00000048482
UniProtP23560P21237
RefSeq (mRNA)NM_001143805.1NM_001048139.1
RefSeq (protein)NP_001137277.1NP_001041604.1
Lokacija (UCSC)Chr 11:
27.68 - 27.74 Mb		Chr 2:
109.67 - 109.73 Mb
PubMed pretraga[1][2]

Neurotrofni moždani faktor (BDNF) je sekretorni protein[2] koji je kod ljudi kodiran BDNF genom.[3][4] BDNF je član neurotrofinske familije faktora rasta, koja je srodna sa kanoničkim „nervnim faktorima rasta“, NGF. Neurotrofinski faktori su prisutni u mozgu i u perifernom nervnom sistemu.

Reference

  1. ↑ Robinson, R. C.; Radziejewski, C.; Stuart, D. I.; Jones, E. Y. (1995). „Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer”. Biochemistry 34 (13): 4139–4146. DOI:10.1021/bi00013a001. PMID 7703225. 
  2. ↑ Binder DK, Scharfman HE (September 2004). „Brain-derived Neurotrophic Factor”. Growth Factors 22 (3): 123–31. DOI:10.1080/08977190410001723308. PMC 2504526. PMID 15518235. 
  3. ↑ Jones KR, Reichardt LF (October 1990). „Molecular cloning of a human gene that is a member of the nerve growth factor family”. Proc. Natl. Acad. Sci. U.S.A. 87 (20): 8060–4. Bibcode 1990PNAS...87.8060J. DOI:10.1073/pnas.87.20.8060. PMC 54892. PMID 2236018. 
  4. ↑ Maisonpierre PC, Le Beau MM, Espinosa R, Ip NY, Belluscio L, de la Monte SM, Squinto S, Furth ME, Yancopoulos GD (July 1991). „Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations”. Genomics 10 (3): 558–68. PMID 1889806. 

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