Timozin α1
Timozin α1 je peptidni fragment izveden iz protimozina alfa, proteina koji je kod ljudi kodira PTMA genom.[2]
Funkcija
Thimozin α1 je glavna komponenta timozinske frakcije 5, koja je odgovorna za aktivnost tog preparata u obnavljanju imunske funkcije kod životinja bez grudne žlezde. To je bio prvi kompletno sekvencirani i sintetisani peptid iz timozinske frakcije 5. Za razliku od β timozina, sa kojim nije genetički i hemijski srodan, timozin α1 se formira kao fragment sa 28 aminokiselina, iz dužeg prekursora sa 113 aminokiselina, protimozina α.[3] On pospešuje ćelijski posredovanu imunost kod ljudi kao i eksperimentalnih životinja.[4]
Terapeutska primena
Timozin α1 je odobren u 35 zemalja za lečenje Hepatitisa B i C, kao i za upotrebu sa vakcinama za pojačavanje imunskog responsa u treatmentu drugih bolesti.[5][6]
Reference
- ↑ Elizondo-Riojas, M. A.; Chamow, S. M.; Tuthill, C. W.; Gorenstein, D. G.; Volk, D. E. (2011). „NMR structure of human thymosin alpha-1”. Biochemical and Biophysical Research Communications 416 (3–4): 356–361. DOI:10.1016/j.bbrc.2011.11.041. PMID 22115779.
- ↑ Manrow RE, Leone A, Krug MS, Eschenfeldt WH, Berger SL (Jul 1992). „The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions”. Genomics 13 (2): 319–31. DOI:10.1016/0888-7543(92)90248-Q. PMID 1612591.
- ↑ Garaci E (September 2007). „Thymosin alpha1: a historical overview”. Ann. N. Y. Acad. Sci. 1112: 14–20. DOI:10.1196/annals.1415.039. PMID 17567941.
- ↑ Wara DW, Goldstein AL, Doyle NE, Ammann AJ (January 1975). „Thymosin activity in patients with cellular immunodeficiency”. N. Engl. J. Med. 292 (2): 70–4. DOI:10.1056/NEJM197501092920204. PMID 1078552.
- ↑ Garaci E, Favalli C, Pica F, et al. (September 2007). „Thymosin alpha 1: from bench to bedside”. Ann. N. Y. Acad. Sci. 1112: 225–34. DOI:10.1196/annals.1415.044. PMID 17600290.
- ↑ Goldstein AL, Goldstein AL (May 2009). „From lab to bedside: emerging clinical applications of thymosin alpha 1”. Expert Opin Biol Ther 9 (5): 593–608. DOI:10.1517/14712590902911412. PMID 19392576.
Literatura
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