MCM2

Komponenta 2 kompleksa minihromozomskog održavanja
Identifikatori
Simboli	MCM2; BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19
Vanjski ID	OMIM: 116945 MGI: 105380 HomoloGene: 3325 GeneCards: MCM2 Gene
EC broj	3.6.4.12
Ontologija gena
Molekulska funkcija	• DNK vezivanje • aktivnosti DNK helikaze • vezivanje za mesto početka DNK replikacije
Ćelijska komponenta	• hromatin • nukleus • nukleoplazma
Biološki proces	• kontrolna tačka ćelijskog ciklusa • G1/S tranzicija mitotičkog ćelijskog ciklusa • S faza mitotičkog ćelijskog ciklusa
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Faktor licenciranja DNK replikacije MCM2 je protein koji je kod ljudi kodiran MCM2 genom.^[1]^[2]

Protein kodiran ovim genom je jedan od visoko konzerviranjih proteina održavanja mini-hromozoma (MCM) koji učestvuju u inicijaciji replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prereplikacionog kompleksa (pre-RC). On učestuje u formiranju replikacionih viljuški i regrutaciji drugih srodnih proteina replikacije DNK. Ovaj protein formira kompleks sa MCM4, 6, i 7, i pokazano je da reguliše helikaznu aktivnost kompleksa. Ovaj protein fosforilišu, i tim putem regulišu, proteinske kinaze CDC2 i CDC7.^[3]

Interakcije

MCM2 formira interakcije sa replikacionim proteinom A1,^[4] AKAP8,^[5] MCM5,^[4]^[6] MCM6,^[4]^[7]^[8]^[9]^[10] MCM7,^[4]^[8]^[9]^[10]^[11] ORC1L,^[4] ORC2L,^[4] ORC4L,^[4] ORC5L,^[4] MCM4,^[4]^[8]^[9]^[12] MCM3^[4] i proteinska kinaza srodna sa kinazom ciklusa ćelijske deobe 7.^[4]

Reference

↑ Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). „Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle”. Biochem Biophys Res Commun 177 (1): 395–400. DOI:10.1016/0006-291X(91)91996-P. PMID 1710453.
↑ Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). „The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21”. Cytogenet Cell Genet 65 (4): 276–7. DOI:10.1159/000133647. PMID 8258304.
↑ „Entrez Gene: MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)”.
↑ ^4,00 ^4,01 ^4,02 ^4,03 ^4,04 ^4,05 ^4,06 ^4,07 ^4,08 ^4,09 ^4,10 Kneissl Margot, Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar 2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. (England) 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.
↑ Eide Turid, Taskén Kristin A, Carlson Cathrine, Williams Gareth, Jahnsen Tore, Taskén Kjetil, Collas Philippe (Jul 2003). „Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication”. J. Biol. Chem. (United States) 278 (29): 26750–6. DOI:10.1074/jbc.M300765200. ISSN 0021-9258. PMID 12740381.
↑ DaFonseca C J, Shu F, Zhang J J (Mar 2001). „Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma”. Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. DOI:10.1073/pnas.061487598. ISSN 0027-8424. PMC 30602. PMID 11248027.
↑ Rual Jean-François, Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature (England) 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
↑ ^8,0 ^8,1 ^8,2 Yabuta Norikazu, Kajimura Naoko, Mayanagi Kouta, Sato Michio, Gotow Takahito, Uchiyama Yasuo, Ishimi Yukio, Nojima Hiroshi (May 2003). „Mammalian Mcm2/4/6/7 complex forms a toroidal structure”. Genes Cells (England) 8 (5): 413–21. DOI:10.1046/j.1365-2443.2003.00645.x. ISSN 1356-9597. PMID 12694531.
↑ ^9,0 ^9,1 ^9,2 You Z, Komamura Y, Ishimi Y (Dec 1999). „Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity”. Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003–15. ISSN 0270-7306. PMC 84885. PMID 10567526.
↑ ^10,0 ^10,1 You Zhiying, Ishimi Yukio, Masai Hisao, Hanaoka Fumio (Nov 2002). „Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex”. J. Biol. Chem. (United States) 277 (45): 42471–9. DOI:10.1074/jbc.M205769200. ISSN 0021-9258. PMID 12207017.
↑ Fujita M, Kiyono T, Hayashi Y, Ishibashi M (Apr 1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP”. J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. DOI:10.1074/jbc.272.16.10928. ISSN 0021-9258. PMID 9099751.
↑ Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (Sep 1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. (UNITED STATES) 271 (39): 24115–22. DOI:10.1074/jbc.271.39.24115. ISSN 0021-9258. PMID 8798650.

Literatura

Nomura N, Miyajima N, Sazuka T, et al. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.”. DNA Res. 1 (1): 27–35. DOI:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).”. DNA Res. 1 (1): 47–56. DOI:10.1093/dnares/1.1.47. PMID 7584028.
Nakatsuru S, Sudo K, Nakamura Y (1995). „Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication.”. Cytogenet. Cell Genet. 68 (3–4): 226–30. DOI:10.1159/000133918. PMID 7842741.
Todorov IT, Pepperkok R, Philipova RN, et al. (1994). „A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division”. J. Cell. Sci. 107 (1): 253–65. PMID 8175912.
Ishimi Y, Ichinose S, Omori A, et al. (1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. 271 (39): 24115–22. DOI:10.1074/jbc.271.39.24115. PMID 8798650.
Fujita M, Yamada C, Tsurumi T, et al. (1998). „Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase”. J. Biol. Chem. 273 (27): 17095–101. DOI:10.1074/jbc.273.27.17095. PMID 9642275.
Jiang W, McDonald D, Hope TJ, Hunter T (1999). „Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication”. EMBO J. 18 (20): 5703–13. DOI:10.1093/emboj/18.20.5703. PMC 1171637. PMID 10523313.
You Z, Komamura Y, Ishimi Y (2000). „Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity”. Mol. Cell. Biol. 19 (12): 8003–15. PMC 84885. PMID 10567526.
Ishimi Y, Komamura-Kohno Y, You Z, et al. (2000). „Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2”. J. Biol. Chem. 275 (21): 16235–41. DOI:10.1074/jbc.M909040199. PMID 10748114.
Masai H, Matsui E, You Z, et al. (2000). „Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks”. J. Biol. Chem. 275 (37): 29042–52. DOI:10.1074/jbc.M002713200. PMID 10846177.
Izumi M, Yanagi K, Mizuno T, et al. (2001). „The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase”. Nucleic Acids Res. 28 (23): 4769–77. DOI:10.1093/nar/28.23.4769. PMC 115166. PMID 11095689.
Burke TW, Cook JG, Asano M, Nevins JR (2001). „Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1”. J. Biol. Chem. 276 (18): 15397–408. DOI:10.1074/jbc.M011556200. PMID 11278932.
Tan DF, Huberman JA, Hyland A, et al. (2002). „MCM2--a promising marker for premalignant lesions of the lung: a cohort study”. BMC Cancer 1: 6. DOI:10.1186/1471-2407-1-6. PMC 35283. PMID 11472637.
Ishimi Y, Komamura-Kohno Y, Arai K, Masai H (2001). „Biochemical activities associated with mouse Mcm2 protein”. J. Biol. Chem. 276 (46): 42744–52. DOI:10.1074/jbc.M106861200. PMID 11568184.
Wohlschlegel JA, Dhar SK, Prokhorova TA, et al. (2002). „Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45”. Mol. Cell 9 (2): 233–40. DOI:10.1016/S1097-2765(02)00456-2. PMID 11864598.
Kodani I, Shomori K, Osaki M, et al. (2002). „Expression of minichromosome maintenance 2 (MCM2), Ki-67, and cell-cycle-related molecules, and apoptosis in the normal-dysplasia-carcinoma sequence of the oral mucosa”. Pathobiology 69 (3): 150–8. DOI:10.1159/000048770. PMID 11872961.
Edwards MC, Tutter AV, Cvetic C, et al. (2002). „MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts”. J. Biol. Chem. 277 (36): 33049–57. DOI:10.1074/jbc.M204438200. PMID 12087101.
Osaki M, Osaki M, Yamashita H, et al. (2003). „Expression of minichromosome maintenance-2 in human malignant fibrous histiocytomas: Correlations with Ki-67 and P53 expression, and apoptosis”. Int. J. Mol. Med. 10 (2): 161–8. DOI:10.3892/ijmm.10.2.161. PMID 12119552.

[pmid1710453-1] Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). „Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle”. Biochem Biophys Res Commun 177 (1): 395–400. DOI:10.1016/0006-291X(91)91996-P. PMID 1710453.

[pmid8258304-2] Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). „The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21”. Cytogenet Cell Genet 65 (4): 276–7. DOI:10.1159/000133647. PMID 8258304.

[entrez-3] „Entrez Gene: MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)”.

[pmid12614612-4] 4,00 ^4,01 ^4,02 ^4,03 ^4,04 ^4,05 ^4,06 ^4,07 ^4,08 ^4,09 ^4,10 Kneissl Margot, Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar 2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. (England) 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.

[pmid12740381-5] Eide Turid, Taskén Kristin A, Carlson Cathrine, Williams Gareth, Jahnsen Tore, Taskén Kjetil, Collas Philippe (Jul 2003). „Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication”. J. Biol. Chem. (United States) 278 (29): 26750–6. DOI:10.1074/jbc.M300765200. ISSN 0021-9258. PMID 12740381.

[pmid11248027-6] DaFonseca C J, Shu F, Zhang J J (Mar 2001). „Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma”. Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. DOI:10.1073/pnas.061487598. ISSN 0027-8424. PMC 30602. PMID 11248027.

[pmid16189514-7] Rual Jean-François, Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature (England) 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.

[pmid12694531-8] 8,0 ^8,1 ^8,2 Yabuta Norikazu, Kajimura Naoko, Mayanagi Kouta, Sato Michio, Gotow Takahito, Uchiyama Yasuo, Ishimi Yukio, Nojima Hiroshi (May 2003). „Mammalian Mcm2/4/6/7 complex forms a toroidal structure”. Genes Cells (England) 8 (5): 413–21. DOI:10.1046/j.1365-2443.2003.00645.x. ISSN 1356-9597. PMID 12694531.

[pmid10567526-9] 9,0 ^9,1 ^9,2 You Z, Komamura Y, Ishimi Y (Dec 1999). „Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity”. Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003–15. ISSN 0270-7306. PMC 84885. PMID 10567526.

[pmid12207017-10] 10,0 ^10,1 You Zhiying, Ishimi Yukio, Masai Hisao, Hanaoka Fumio (Nov 2002). „Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex”. J. Biol. Chem. (United States) 277 (45): 42471–9. DOI:10.1074/jbc.M205769200. ISSN 0021-9258. PMID 12207017.

[pmid9099751-11] Fujita M, Kiyono T, Hayashi Y, Ishibashi M (Apr 1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP”. J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. DOI:10.1074/jbc.272.16.10928. ISSN 0021-9258. PMID 9099751.

[pmid8798650-12] Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (Sep 1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. (UNITED STATES) 271 (39): 24115–22. DOI:10.1074/jbc.271.39.24115. ISSN 0021-9258. PMID 8798650.

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MCM2

Interakcije

Reference

Literatura

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