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Replikacioni faktor C (aktivator 1) 1, 145kDa
	; Prikaz baziran na PDB 2EBU.
Dostupne strukture
	2EBU, 2K6G, 2K7F
Identifikatori
Simboli	RFC1; A1; MHCBFB; PO-GA; RECC1; RFC; RFC140
Vanjski ID	OMIM: 102579 MGI: 97891 HomoloGene: 2187 GeneCards: RFC1 Gene
Ontologija gena
Molekulska funkcija	• aktivnost punjača DNK stege; • proteinsko vezivanje; • ATP vezivanje;
Ćelijska komponenta	• nukleoplazma; • DNA replikacioni faktor C kompleks;
Biološki proces	• S faza mitotičkog ćelijskog ciklusa; • mitotički ćelijski ciklus; • telomerno održavanje rekombinacijom;
Pregled RNK izražavanja
	podaci
Ortolozi

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Replikacioni faktor C, podjednica 1 je protein koji je kod ljudi kodiran RFC1 genom.^[1]^[2]

Protein kodiran ovim genom je velika podjedinica replikacionog faktora C, koji je pomoćni protein DNK polimeraze sa pet podjedinica. Replikacioni faktor C je od DNK zavisna ATPaza koja je neophodna za eukariotsku DNK replikaciju i popravku. Protein deluje kao aktivator DNK polimeraza, putem vezivanja za 3' kraj prajmera, i promoviše koordiniranu sintezu oba lanca. On takođe doprinosi stabilnosti telomera.^[2]

Interakcije

RFC1 formira interakcije sa BRD4,^[3] HDAC1,^[4] RFC3,^[5]^[6]^[7] RELA^[8] i PCNA.^[3]^[9]^[10]^[11]^[12]

Reference

↑ Luckow B, Bunz F, Stillman B, Lichter P, Schutz G (Mar 1994). „Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans”. Mol Cell Biol 14 (3): 1626–34. PMC 358521. PMID 8114700.
↑ ^2,0 ^2,1 „Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa”.
↑ ^3,0 ^3,1 Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep 2002). „A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase”. Mol. Cell. Biol. (United States) 22 (18): 6509–20. DOI:10.1128/MCB.22.18.6509-6520.2002. ISSN 0270-7306. PMC 135621. PMID 12192049.
↑ Anderson, Lisa A; Perkins Neil D (Aug 2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. (United States) 277 (33): 29550–4. DOI:10.1074/jbc.M200513200. ISSN 0021-9258. PMID 12045192.
↑ Ellison, V; Stillman B (Mar 1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. (UNITED STATES) 273 (10): 5979–87. DOI:10.1074/jbc.273.10.5979. ISSN 0021-9258. PMID 9488738.
↑ Uhlmann, F; Cai J, Flores-Rozas H, Dean F B, Finkelstein J, O'Donnell M, Hurwitz J (Jun 1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6521–6. DOI:10.1073/pnas.93.13.6521. ISSN 0027-8424. PMC 39056. PMID 8692848.
↑ Tomida, Junya; Masuda Yuji, Hiroaki Hidekazu, Ishikawa Tomoko, Song Ihnyoung, Tsurimoto Toshiki, Tateishi Satoshi, Shiomi Tadahiro, Kamei Yasuhiro, Kim Jinhyeong, Kamiya Kenji, Vaziri Cyrus, Ohmori Haruo, Todo Takeshi (Apr 2008). „DNA Damage-induced Ubiquitylation of RFC2 Subunit of Replication Factor C Complex”. J. Biol. Chem. (United States) 283 (14): 9071–9. DOI:10.1074/jbc.M709835200. ISSN 0021-9258. PMC 2431014. PMID 18245774.
↑ Anderson, Lisa A; Perkins Neil D (Jan 2003). „Regulation of RelA (p65) Function by the Large Subunit of Replication Factor C”. Mol. Cell. Biol. (United States) 23 (2): 721–32. DOI:10.1128/MCB.23.2.721-732.2003. ISSN 0270-7306. PMC 151544. PMID 12509469.
↑ Fotedar, R; Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (Aug 1996). „A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells”. EMBO J. (ENGLAND) 15 (16): 4423–33. ISSN 0261-4189. PMC 452166. PMID 8861969.
↑ Mossi, R; Jónsson Z O, Allen B L, Hardin S H, Hübscher U (Jan 1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. (UNITED STATES) 272 (3): 1769–76. DOI:10.1074/jbc.272.3.1769. ISSN 0021-9258. PMID 8999859.
↑ van der Kuip, H; Carius B, Haque S J, Williams B R, Huber C, Fischer T (Apr 1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. (GERMANY) 77 (4): 386–92. DOI:10.1007/s001090050365. ISSN 0946-2716. PMID 10353443.
↑ Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. (United States) 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. ISSN 0021-9258. PMID 12171929.

Literatura

Lu Y, Riegel AT (1994). „The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA”. Gene 145 (2): 261–5. DOI:10.1016/0378-1119(94)90017-5. PMID 7914507.
Bunz F, Kobayashi R, Stillman B (1994). „cDNAs encoding the large subunit of human replication factor C”. Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11014–8. DOI:10.1073/pnas.90.23.11014. PMC 47912. PMID 8248204.
Lu Y, Zeft AS, Riegel AT (1993). „Cloning and expression of a novel human DNA binding protein, PO-GA”. Biochem. Biophys. Res. Commun. 193 (2): 779–86. DOI:10.1006/bbrc.1993.1693. PMID 8512577.
Uhlmann F, Cai J, Flores-Rozas H, et al. (1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521–6. DOI:10.1073/pnas.93.13.6521. PMC 39056. PMID 8692848.
Fotedar R, Mossi R, Fitzgerald P, et al. (1996). „A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells”. EMBO J. 15 (16): 4423–33. PMC 452166. PMID 8861969.
Uchiumi F, Ohta T, Tanuma S (1997). „Replication factor C recognizes 5'-phosphate ends of telomeres”. Biochem. Biophys. Res. Commun. 229 (1): 310–5. DOI:10.1006/bbrc.1996.1798. PMID 8954124.
Mossi R, Jónsson ZO, Allen BL, et al. (1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. 272 (3): 1769–76. DOI:10.1074/jbc.272.3.1769. PMID 8999859.
Cujec TP, Cho H, Maldonado E, et al. (1997). „The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme”. Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429.
Ubeda M, Habener JF (1997). „The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis”. J. Biol. Chem. 272 (31): 19562–8. DOI:10.1074/jbc.272.31.19562. PMID 9235961.
Rhéaume E, Cohen LY, Uhlmann F, et al. (1998). „The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis”. EMBO J. 16 (21): 6346–54. DOI:10.1093/emboj/16.21.6346. PMC 1170241. PMID 9351817.
Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. 273 (10): 5979–87. DOI:10.1074/jbc.273.10.5979. PMID 9488738.
Coll JM, Hickey RJ, Cronkey EA, et al. (1998). „Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome”. Oncol. Res. 9 (11–12): 629–39. PMID 9563011.
Allen BL, Uhlmann F, Gaur LK, et al. (1998). „DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C”. Nucleic Acids Res. 26 (17): 3877–82. DOI:10.1093/nar/26.17.3877. PMC 147807. PMID 9705493.
van der Kuip H, Carius B, Haque SJ, et al. (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386–92. DOI:10.1007/s001090050365. PMID 10353443.
Wang Y, Cortez D, Yazdi P, et al. (2000). „BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures”. Genes Dev. 14 (8): 927–39. PMC 316544. PMID 10783165.
Yazdi PT, Wang Y, Zhao S, et al. (2002). „SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint”. Genes Dev. 16 (5): 571–82. DOI:10.1101/gad.970702. PMC 155356. PMID 11877377.
Anderson LA, Perkins ND (2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. 277 (33): 29550–4. DOI:10.1074/jbc.M200513200. PMID 12045192.
Ohta S, Shiomi Y, Sugimoto K, et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. PMID 12171929.
Maruyama T, Farina A, Dey A, et al. (2002). „A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase”. Mol. Cell. Biol. 22 (18): 6509–20. DOI:10.1128/MCB.22.18.6509-6520.2002. PMC 135621. PMID 12192049.

[pmid8114700-1] Luckow B, Bunz F, Stillman B, Lichter P, Schutz G (Mar 1994). „Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans”. Mol Cell Biol 14 (3): 1626–34. PMC 358521. PMID 8114700.

[entrez-2] 2,0 ^2,1 „Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa”.

[pmid12192049-3] 3,0 ^3,1 Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep 2002). „A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase”. Mol. Cell. Biol. (United States) 22 (18): 6509–20. DOI:10.1128/MCB.22.18.6509-6520.2002. ISSN 0270-7306. PMC 135621. PMID 12192049.

[pmid12045192-4] Anderson, Lisa A; Perkins Neil D (Aug 2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. (United States) 277 (33): 29550–4. DOI:10.1074/jbc.M200513200. ISSN 0021-9258. PMID 12045192.

[pmid9488738-5] Ellison, V; Stillman B (Mar 1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. (UNITED STATES) 273 (10): 5979–87. DOI:10.1074/jbc.273.10.5979. ISSN 0021-9258. PMID 9488738.

[pmid8692848-6] Uhlmann, F; Cai J, Flores-Rozas H, Dean F B, Finkelstein J, O'Donnell M, Hurwitz J (Jun 1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6521–6. DOI:10.1073/pnas.93.13.6521. ISSN 0027-8424. PMC 39056. PMID 8692848.

[pmid18245774-7] Tomida, Junya; Masuda Yuji, Hiroaki Hidekazu, Ishikawa Tomoko, Song Ihnyoung, Tsurimoto Toshiki, Tateishi Satoshi, Shiomi Tadahiro, Kamei Yasuhiro, Kim Jinhyeong, Kamiya Kenji, Vaziri Cyrus, Ohmori Haruo, Todo Takeshi (Apr 2008). „DNA Damage-induced Ubiquitylation of RFC2 Subunit of Replication Factor C Complex”. J. Biol. Chem. (United States) 283 (14): 9071–9. DOI:10.1074/jbc.M709835200. ISSN 0021-9258. PMC 2431014. PMID 18245774.

[pmid12509469-8] Anderson, Lisa A; Perkins Neil D (Jan 2003). „Regulation of RelA (p65) Function by the Large Subunit of Replication Factor C”. Mol. Cell. Biol. (United States) 23 (2): 721–32. DOI:10.1128/MCB.23.2.721-732.2003. ISSN 0270-7306. PMC 151544. PMID 12509469.

[pmid8861969-9] Fotedar, R; Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (Aug 1996). „A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells”. EMBO J. (ENGLAND) 15 (16): 4423–33. ISSN 0261-4189. PMC 452166. PMID 8861969.

[pmid8999859-10] Mossi, R; Jónsson Z O, Allen B L, Hardin S H, Hübscher U (Jan 1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. (UNITED STATES) 272 (3): 1769–76. DOI:10.1074/jbc.272.3.1769. ISSN 0021-9258. PMID 8999859.

[pmid10353443-11] van der Kuip, H; Carius B, Haque S J, Williams B R, Huber C, Fischer T (Apr 1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. (GERMANY) 77 (4): 386–92. DOI:10.1007/s001090050365. ISSN 0946-2716. PMID 10353443.

[pmid12171929-12] Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. (United States) 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. ISSN 0021-9258. PMID 12171929.

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