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Dimetilglicin
| Dimetilglicin
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| IUPAC ime
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| 2-(Dimetilamino)sirćetna kiselina[1] |
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| Drugi nazivi
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N,N-Dimetilglicin
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| Identifikacija
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| CAS registarski broj
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1118-68-9  Y
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| PubChem[2][3]
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673
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| ChemSpider[4]
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653 Y
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| EINECS broj
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214-267-8
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| DrugBank
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DB02083
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| KEGG[5]
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C01026
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| MeSH
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dimethylglycine
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| ChEBI
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17724
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| RTECS registarski broj toksičnosti
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MB9865000
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| Bajlštajn
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1700261
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| Gmelin Referenca
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82215
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| 3DMet
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B00224
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| Jmol-3D slike
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Slika 1
Slika 2
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CN(C)Cc(:[o]):[oH]
CN(C)CC(O)=O |
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InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7) Y
Kod: FFDGPVCHZBVARC-UHFFFAOYSA-N Y |
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| Svojstva
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| Molekulska formula
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C4H9NO2
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| Molarna masa
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103.12 g mol−1
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| Agregatno stanje
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Beli kristali
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| Miris
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Bez mirisa
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| Tačka topljenja
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178-182 °C, 451-455 K, 352-360 °F
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| Opasnost
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| LD50
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>650 mg kg−1 (oralno, pacov)
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| Srodna jedinjenja
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| Srodna alkanoinske kiseline
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| Srodna jedinjenja
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Dimetilacetamid
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 Y (šta je ovo?)
(verifikuj)
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
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| Infobox references
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Dimetilglicin (DMG) je derivat aminokiseline glicina sa strukturnom formulom (CH3)2NCH2COOH. On je prisutan u pasulju i jetri. On se može formirati iz trimetilglicina nakon gubitka jedne od njegovih metil grupa. On je takođe nusproizvod metabolizma holina.
Upotrebe
Dimetilglicin je predložen za moguću primenu kao sredstvo za poboljšanje atletske performance, imunostimulant, i za tretman autizma, epilepsije, i mitohondrijalne bolesti.[6][7] Objavljene studije su pokazale da nema znatne razlike imeđu tretmana autiyma DMG-om i placebom.[8][9]
Reference
- ↑ „dimethylglycine - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004.. Identification. Pristupljeno 24. 4. 2012.
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ „Dimethylglycine”. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. 8. 12. 2009..
- ↑ Chinnery P, Majamaa K, Turnbull D, Thorburn D (2006). „Treatment for mitochondrial disorders”. Cochrane Database of Systematic Reviews (Online) (1): CD004426. DOI:10.1002/14651858.CD004426.pub2. PMID 16437486.
- ↑ Bolman WM, Richmond JA (June 1999). „A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder”. Journal of Autism and Developmental Disorders 29 (3): 191–4. PMID 10425581.
- ↑ Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (March 2001). „Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder”. Journal of Child Neurology 16 (3): 169–73. PMID 11305684.
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