Valpromida

Valpromida
Alerta sobre risco à saúde
Identificadores
Número CAS 2430-27-5
PubChem 71113
Número EINECS 219-394-2
DrugBank DB04165
ChemSpider 64264
KEGG D02766
MeSH dipropylacetamide
ChEBI 74562
SMILES
Propriedades
Fórmula química C8H17NO
Massa molar 143.22 g mol-1
Aparência Pó cristalino
Ponto de fusão

125

log P 2.041
Farmacologia
Código ATC N03AG02
Riscos associados
LD50
  • 438 mg kg−1 (intraperitoneal, ratos)
  • 890.0 mg kg−1 (oral, ratOS)
Compostos relacionados
relacionados Valnoctamida [en]
Compostos relacionados
Página de dados suplementares
Estrutura e propriedades n, εr, etc.
Dados termodinâmicos Phase behaviour
Solid, liquid, gas
Dados espectrais UV, IV, RMN, EM
Exceto onde denotado, os dados referem-se a
materiais sob condições normais de temperatura e pressão
Referências e avisos gerais sobre esta caixa.
Alerta sobre risco à saúde.

A valpromida (nome comercial: Depamida) é um derivado de carboxamida do ácido valpróico usado no tratamento da epilepsia e alguns transtornos de humor. É metabolizada extensivamente (~80%) em ácido valpróico (que age também como anticonvulsivante), mas possui propriedades anticonvulsivantes próprias. Os níveis plasmáticos da valpromida são mais estáveis e superior aos do ácido valpróico ou valproato, de modo que parece ser mais eficaz na prevenção de convulsões febris. No entanto, é cem vezes mais potente como um inibidor da epóxido hidroxilase microssomal do fígado. Por isso, o uso com outros inibidores da epóxido hidrolase, como a carbamazepina, aumenta o potencial de intoxicação e é desaconselhado clinicamente.[1]

A valpromida é formada pela reação do ácido valpróico e amônia utilizando o cloreto de acila como intermediário.[2]

Na forma pura, a valpromida é um pó cristalino branco e tem ponto de fusão de cerca de 125-126 ° C. Está disponível no mercado em alguns países europeus[1] e no México.[3]

Ver também

Referências

  1. ↑ a b Bialer, Meir (fevereiro de 1991). «Clinical Pharmacology of Valpromide:». Clinical Pharmacokinetics (em inglês) (2): 114–122. ISSN 0312-5963. doi:10.2165/00003088-199120020-00003. Consultado em 23 de abril de 2022 
  2. ↑ Tasso, Silvina M.; Moon, Sung Ch; Bruno-Blanch, Luis E.; Estiú, Guillermina L. (15 de julho de 2004). «Characterization of the anticonvulsant profile of valpromide derivatives». Bioorganic & Medicinal Chemistry (14): 3857–3869. ISSN 0968-0896. PMID 15210153. doi:10.1016/j.bmc.2004.05.003. Consultado em 23 de abril de 2022 
  3. ↑ «Valpromide Market In 2022 : Industry Concentration Ratio, Upstream Markets, Trend Analysis, Growth, Opportunities, Risks in the upcoming period 2022 to 2028». MarketWatch (em inglês). Consultado em 23 de abril de 2022 

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