Snake venom factor V activator

Snake venom factor V activator
Identifiers
EC no.3.4.21.95
CAS no.471269-12-2
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Snake venom factor V activator (EC 3.4.21.95) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Fully activates human clotting factor V by a single cleavage at the Trp-Tyr-Leu-Arg1545-Ser-Asn-Asn-Gly bond.

This enzyme is present in venom of Daboia russelii.

References

  1. ^ Kisiel W, Canfield WM (1981). "Snake venom proteases that activate blood-coagulation factor V". Proteolytic Enzymes, Part C. Methods in Enzymology. Vol. 80 Pt C. pp. 275–85. doi:10.1016/s0076-6879(81)80024-9. ISBN 978-0-12-181980-4. PMID 7043192.
  2. ^ Tokunaga F, Nagasawa K, Tamura S, Miyata T, Iwanaga S, Kisiel W (November 1988). "The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-V alpha, -V beta, and -V gamma and their complete amino acid sequences". The Journal of Biological Chemistry. 263 (33): 17471–81. doi:10.1016/S0021-9258(19)77860-0. PMID 3053712.