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STX16
Identifiers
Aliases	STX16, SYN16, syntaxin 16, SYN-16
External IDs	OMIM: 603666; MGI: 1923396; HomoloGene: 2791; GeneCards: STX16; OMA:STX16 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	58,679,526 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	173,941,564 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sural nerve; ; corpus callosum; ; superficial temporal artery; ; Pituitary Gland; ; right hemisphere of cerebellum; ; body of uterus; ; C1 segment; ; right ovary; ; anterior pituitary;
	Top expressed in
	hand; ; neural layer of retina; ; otolith organ; ; utricle; ; thymus; ; lens; ; cerebellar cortex; ; primary visual cortex; ; yolk sac; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	SNAP receptor activity; protein binding; syntaxin binding; SNARE binding;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; membrane; intracellular membrane-bounded organelle; Golgi cisterna; focal adhesion; trans-Golgi network; SNARE complex; endoplasmic reticulum; perinuclear region of cytoplasm; cytosol; trans-Golgi network membrane; Golgi membrane; endomembrane system; integral component of synaptic vesicle membrane;
Biological process	vesicle docking; retrograde transport, endosome to Golgi; protein transport; intracellular protein transport; vesicle fusion; Golgi ribbon formation; vesicle-mediated transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	8675
	228960
	ENSG00000124222
	ENSMUSG00000027522
	O14662
	Q8BVI5
NM_001001433; NM_001001434; NM_001134772; NM_001134773; NM_001204868;
	NM_003763
NM_001102423; NM_001102424; NM_001102425; NM_172675; NM_001363029;
	NM_001363030; NM_001363031
	NP_001001433; NP_001128244; NP_001128245; NP_001191797; NP_003754
NP_001095893; NP_001095894; NP_001095895; NP_766263; NP_001349958;
	NP_001349959; NP_001349960
	Wikidata
View/Edit Human	View/Edit Mouse

Syntaxin-16 is a protein that in humans is encoded by the STX16 gene.^[5]^[6]^[7]^[8]

It has been associated with pseudohypoparathyroidism type Ib. Losing this gene causes loss of methylation at GNAS1 exon A/B.^[7]

Interactions

STX16 has been shown to interact with VAMP4.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124222 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027522 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang BL, Low DY, Lee SS, Tan AE, Hong W (Jan 1998). "Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins". Biochemical and Biophysical Research Communications. 242 (3): 673–9. doi:10.1006/bbrc.1997.8029. PMID 9464276.
^ Simonsen A, Bremnes B, Rønning E, Aasland R, Stenmark H (Mar 1998). "Syntaxin-16, a putative Golgi t-SNARE". European Journal of Cell Biology. 75 (3): 223–31. doi:10.1016/S0171-9335(98)80116-7. PMID 9587053.
^ ^a ^b Linglart A, Gensure RC, Olney RC, Jüppner H, Bastepe M (May 2005). "A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS". American Journal of Human Genetics. 76 (5): 804–14. doi:10.1086/429932. PMC 1199370. PMID 15800843.
^ "Entrez Gene: STX16 syntaxin 16".
^ Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.