5A1U, 5A1V, 5A1W, 5A1X, 5A1Y
1314
12847
n/a
ENSMUSG00000026553
P53621
Q8CIE6
NM_004371NM_001098398
NM_009938
NP_001091868NP_004362
NP_034068
Coatomer subunit alpha is a protein that in humans is encoded by the COPA gene.[4][5]
In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1, the homologous alpha subunit of the coatomer complex in yeast.[6] Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.[5]
COPA (gene) has been shown to interact with COPE[7][8][9] and COPB1.[10]
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
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