Nystatin

Nystatin
Clinical data
Trade namesMycostatin, others[1]
AHFS/Drugs.comMonograph
MedlinePlusa682758
License data
Routes of
administration		Topical, vaginal, by mouth
Drug classPolyene antifungal medication[1]
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability0% on oral ingestion
MetabolismNone (not extensively absorbed)
Elimination half-lifeDependent upon GI transit time
ExcretionFecal (100%)
Identifiers
  • (1S,3R,4R,7R,9R,11R,15S,16R,17R,18S,19E,21E, 25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-β-L-mannopyranosyl)oxy]-1, 3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14, 39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.014.317 Edit this at Wikidata
Chemical and physical data
FormulaC47H75NO17
Molar mass926.107 g·mol−1
3D model (JSmol)
Melting point44–46 °C (111–115 °F)
  • CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
  • InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1 ☒N
  • Key:VQOXZBDYSJBXMA-NQTDYLQESA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Nystatin, sold under the brand name Mycostatin among others, is an antifungal medication.[1] It is used to treat Candida infections of the skin including diaper rash, thrush, esophageal candidiasis, and vaginal yeast infections.[1] It may also be used to prevent candidiasis in those who are at high risk.[1] Nystatin may be used by mouth, in the vagina, or applied to the skin.[1]

Common side effects when applied to the skin include burning, itching, and a rash.[1] Common side effects when taken by mouth include vomiting and diarrhea.[1] During pregnancy use in the vagina is safe while other formulations have not been studied in this group.[1] It works by disrupting the cell membrane of the fungal cells.[1]

Nystatin was discovered in 1950 by Rachel Fuller Brown and Elizabeth Lee Hazen.[2] It was the first polyene macrolide antifungal.[3] It is on the World Health Organization's List of Essential Medicines.[4] It is available as a generic medication.[1] It is made from the bacterium Streptomyces noursei.[2] In 2022, it was the 236th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[5][6]

Medical uses

Skin, vaginal, mouth, and esophageal Candida infections usually respond well to treatment with nystatin. Infections of nails or hyperkeratinized skin do not respond well.[7]

When given parenterally, its activity is reduced due to presence of plasma.[8]

Oral nystatin is often used as a preventive treatment in people who are at risk for fungal infections, such as AIDS patients with a low CD4+ count and people receiving chemotherapy. It has been investigated for use in patients after liver transplantation, but fluconazole was found to be much more effective for preventing colonization, invasive infection, and death.[9] It is effective in treating oral candidiasis in elderly people who wear dentures.[10]

It is also used in very low birth-weight (less than 1500 g or 3 lb 5oz o) infants to prevent invasive fungal infections, although fluconazole is the preferred treatment. It has been found to reduce the rate of invasive fungal infections and also reduce deaths when used in these babies.[11]

Liposomal nystatin is not commercially available, but investigational use has shown greater in vitro activity than colloidal formulations of amphotericin B, and demonstrated effectiveness against some amphotericin B-resistant forms of fungi.[12] It offers an intriguing possibility for difficult-to-treat systemic infections, such as invasive aspergillosis, or infections that demonstrate resistance to amphotericin B. Cryptococcus is also sensitive to nystatin. Additionally, liposomal nystatin appears to cause fewer cases of and less severe nephrotoxicity than observed with amphotericin B.[12]

Adverse effects

Bitter taste and nausea are more common than most other adverse effects.[7]

The oral suspension form produces a number of adverse effects including but not limited to:[13]

  1. Diarrhea
  2. Abdominal pain
  3. Rarely, tachycardia, bronchospasm, facial swelling, muscle aches

Both the oral suspension and the topical form can cause:

  1. Hypersensitivity reactions, including Stevens–Johnson syndrome in some cases[14]
  2. Rash, itching, burning and acute generalized exanthematous pustulosis[15]

Too high of a dosage can potentially lead to additional side effects such as:[16]

  1. Nephrotoxicity
  2. Hypokalemia
  3. Chills and skin rash

Mechanism of action

Like amphotericin B and natamycin, nystatin is an ionophore.[17] It binds to ergosterol, a major component of the fungal cell membrane. When present in sufficient concentrations, it forms pores in the membrane that lead to K+ leakage, acidification, and death of the fungus.[18] Ergosterol is a sterol unique to fungi, so the drug does not have such catastrophic effects on animals or plants. However, many of the systemic/toxic effects of nystatin in humans are attributable to its binding to mammalian sterols, namely cholesterol. This is the effect that accounts for the nephrotoxicity observed when high serum levels of nystatin are achieved.[16] Despite the molecular similarities and differences of ergosterol and cholesterol, there is currently no consensus as to why nystatin has a higher binding affinity for ergosterol because it remains unclear how the nystatin pores are formed.[16] Researchers have concluded thus far that nystatin pores are formed from 4-12 nystatin molecules, with an unknown number of the necessary sterol interactions.[19]

Nystatin also impacts cell membrane potential and transport by lipid peroxidation.[20] Conjugated double bonds in nystatin's structure steal electron density from ergosterol in fungal cell membranes. Lipid peroxidation alters the hydrophilicity of the interior of channels in the membrane, which is necessary to transport ions and polar molecules. Disruption of membrane transport from nystatin results in rapid cell death. Lipid peroxidation by nystatin also contributes significantly to K+ leakage due to structural modifications of the membrane.[21]

Biosynthesis

Nystatin A1 (often called nystatin) is biosynthesized by a bacterial strain, Streptomyces noursei.[22] The structure of this active compound is characterized as a polyene macrolide with a deoxysugar D-mycosamine, an aminoglycoside.[22] The genomic sequence of nystatin reveals the presence of the polyketide loading module (nysA), six polyketide syntheses modules (nysB, nysC, nysI, nysJ, and nysK) and two thioesterase modules (nysK and nysE).[22] It is evident that the biosynthesis of the macrolide functionality follows the polyketide synthase I pathway.[23]

Following the biosynthesis of the macrolide, the compound undergoes post-synthetic modifications, which are aided by the following enzymes: GDP-mannose dehydratase (nysIII), P450 monooxygenase (nysL and nysN), aminotransferase (nysDII), and glycosyltransferase (nysDI).[22] The biosynthetic pathway is thought to proceed as shown to yield nystatin.

  • Loading to 5
    Loading to 5
  • Modules 6-12
    Modules 6-12
  • Modules 13 -18
    Modules 13 -18
  • Completed molecule
    Completed molecule

The melting point of nystatin is 44 - 46 °C.[24]

History

Elizabeth Lee Hazen (left) and Rachel Fuller Brown in 1955.

Like many other antifungals and antibiotics, nystatin has bacterial origin. It was isolated from Streptomyces noursei in 1950 by Elizabeth Lee Hazen and Rachel Fuller Brown, who were doing research for the Division of Laboratories and Research of the New York State Department of Health. Hazen found a promising micro-organism in the soil of a friend's dairy farm. She named it Streptomyces noursei, after Jessie Nourse, the wife of the farm's owner.[25] Hazen and Brown named nystatin after the New York State Health Department in 1954.[26] The two discoverers patented the drug, and then donated the $13 million in profits to a foundation to fund similar research.[27]

Other uses

Penicillium-infected tangerine: The spot absent of growth had nystatin applied to it before the fungus covered the fruit.

It is also used in cellular biology as an inhibitor of the lipid raft-caveolae endocytosis pathway on mammalian cells, at concentrations around 3 μg/ml.[citation needed]

In certain cases, a nystatin derivative has been used to prevent the spread of mold on objects such as works of art. For example, it was applied to wood panel paintings damaged as a result of the Arno River Flood of 1966 in Florence, Italy.[28]

Nystatin is also used as a tool by scientists performing "perforated" patch-clamp electrophysiological recordings of cells. When loaded in the recording pipette, it allows for measurement of electrical currents without washing out the intracellular contents, because it forms pores in the cell membrane that are permeable to only monovalent ions,[29] preferably cations such as sodium, potassium, lithium, and cesium.[30]

This is a depiction of what a fusion event may look like when seen on a current measurement. There is a sudden jump in the current, followed by a slower recover as the current returns to its baseline measurement from before the fusion event. This fusion event would interrupt the stability of a nystatin pore.

Another electrophysiological measurement that can be made is fusion event duration in a nystatin-ergosterol based system. Fusions are measured while the voltage is held constant, and is characterized by a spike in the current that then returns to the baseline current as the nystatin channels close. When present in smaller concentrations, nystatin momentarily forms pores that allows a vesicle fusion to occur more easily; that fusion then interrupts the pore stability and the nystatin and ergosterol disperse from each other.[31] Conversely, researchers have found that the half-life of these nystatin pores increase with an increased dosage level of nystatin to the membrane systems. This indicates a lower energy of both the lipid membrane and the ionophores when there is a higher concentration of nystatin.[32]

Society and culture

Formulations

  • An oral suspension form is used for the prophylaxis or treatment of oropharyngeal thrush, a superficial candidal infection of the mouth and pharynx.
  • A tablet form is preferred for candidal infections in the intestines.
  • Nystatin is available as a topical cream and can be used for superficial candidal infections of the skin.
  • Additionally, a liposomal formulation of nystatin was investigated in the 1980s and into the early 21st century. The liposomal form was intended to resolve problems arising from the poor solubility of the parent molecule and the associated systemic toxicity of the free drug.
  • Nystatin pastilles have been shown to be more effective in treating oral candidiasis than nystatin suspensions.[10]

Due to its toxicity profile when high levels in the serum are obtained, no injectable formulations of nystatin are on the US market. However, injectable formulations have been investigated in the past.[12]

Brand names

References

  1. ^ a b c d e f g h i j k "Nystatin". American Society of Health-System Pharmacists. Archived from the original on 3 February 2016. Retrieved 27 January 2016.
  2. ^ a b Espinel-Ingroff AV (2013). Medical Mycology in the United States a Historical Analysis (1894-1996). Dordrecht: Springer Netherlands. p. 62. ISBN 9789401703116. Archived from the original on 2 February 2016.
  3. ^ Gupte M, Kulkarni P, Ganguli BN (January 2002). "Antifungal antibiotics". Applied Microbiology and Biotechnology. 58 (1): 46–57. doi:10.1007/s002530100822. PMID 11831475. S2CID 8015426.
  4. ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  5. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  6. ^ "Nystatin Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
  7. ^ a b Hilal-Dandan R, Knollmann B, Brunton L (5 December 2017). Brunton LL, Knollmann BC, Hilal-Dandan R (eds.). Goodman & Gilman's the Pharmacological Basis of Therapeutics (Thirteenth ed.). New York: McGraw Hill / Medical. ISBN 978-1-259-58473-2. OCLC 994570810.
  8. ^ Satoskar RS, Rege N, Bhandarkar SD (2015). Pharmacology and Pharmacotherapeutics. Chennai: Elsevier. ISBN 978-8131243619. OCLC 978526697.
  9. ^ Gøtzsche PC, Johansen HK (September 2014). "Nystatin prophylaxis and treatment in severely immunodepressed patients". The Cochrane Database of Systematic Reviews. 2014 (9): CD002033. doi:10.1002/14651858.CD002033.pub2. PMC 6457783. PMID 25188770.
  10. ^ a b Lyu X, Zhao C, Yan ZM, Hua H (2016). "Efficacy of nystatin for the treatment of oral candidiasis: a systematic review and meta-analysis". Drug Design, Development and Therapy. 10: 1161–1171. doi:10.2147/DDDT.S100795. PMC 4801147. PMID 27042008.
  11. ^ Pappas PG, Kauffman CA, Andes D, Benjamin DK, Calandra TF, Edwards JE, et al. (March 2009). "Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America". Clinical Infectious Diseases. 48 (5): 503–535. doi:10.1086/596757. PMC 7294538. PMID 19191635.
  12. ^ a b c Hamill RJ (2003). "Liposomal Nystatin". In Dismukes WE, Pappas PG, Sobel JD (eds.). Clinical Mycology. Oxford: Oxford University Press. pp. 50–53. ISBN 978-0-19-514809-1.
  13. ^ "Nystatin (Oral route)". Micromedex Detailed Drug Information. PubMed Health, U.S. National Library of Medicine. Archived from the original on 21 December 2013. Retrieved 1 April 2014.
  14. ^ "FDA approved package insert" (PDF). Archived (PDF) from the original on 21 April 2014.
  15. ^ Rosenberger A, Tebbe B, Treudler R, Orfanos CE (June 1998). "[Acute generalized exanthematous pustulosis, induced by nystatin]". Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, und Verwandte Gebiete (in German). 49 (6): 492–495. doi:10.1007/s001050050776. PMID 9675578. S2CID 10935411.
  16. ^ a b c Groll AH, Piscitelli SC, Walsh TJ (1 January 1998), August JT, Anders MW, Murad F, Coyle JT (eds.), Clinical Pharmacology of Systemic Antifungal Agents: A Comprehensive Review of Agents in Clinical Use, Current Investigational Compounds, and Putative Targets for Antifungal Drug Development, Advances in Pharmacology, vol. 44, Academic Press, pp. 343–500, doi:10.1016/S1054-3589(08)60129-5, ISBN 9780120329458, PMID 9547888, retrieved 9 December 2023
  17. ^ Rang HP, Dale MM, Flower RJ, Henderson G (21 January 2015). Rang and Dale's pharmacology (Eighth ed.). [United Kingdom]: Churchill Livingstone. ISBN 978-0-7020-5362-7. OCLC 903083639.
  18. ^ Hammond SM (1977). Biological activity of polyene antibiotics. Progress in Medicinal Chemistry. Vol. 14. pp. 105–79. doi:10.1016/S0079-6468(08)70148-6. ISBN 9780720406450. PMID 345355.
  19. ^ Helrich CS, Schmucker JA, Woodbury DJ (August 2006). "Evidence that nystatin channels form at the boundaries, not the interiors of lipid domains". Biophysical Journal. 91 (3): 1116–1127. Bibcode:2006BpJ....91.1116H. doi:10.1529/biophysj.105.076281. PMC 1563755. PMID 16679364.
  20. ^ Welman E, Peters TJ (June 1976). "Properties of lysosomes in guinea pig heart: subcellular distribution and in vitro stability". Journal of Molecular and Cellular Cardiology. 8 (6): 443–463. Bibcode:1993BpJ....64...92B. doi:10.1016/S0006-3495(93)81343-2. PMC 1262305. PMID 7679.
  21. ^ Stark G (July 1991). "The effect of ionizing radiation on lipid membranes". Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes. 1071 (2): 103–122. doi:10.1016/0304-4157(91)90020-w. PMID 1854791.
  22. ^ a b c d Fjaervik E, Zotchev SB (June 2005). "Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei". Applied Microbiology and Biotechnology. 67 (4): 436–443. doi:10.1007/s00253-004-1802-4. PMID 15700127. S2CID 19291518.
  23. ^ Dewick PM (2009). Medicinal Natural Products: A Biosynthetic Approach (3rd ed.). UK: John Wiley & Sons Ltd. ISBN 978-0-471-97478-9.
  24. ^ Elsner Z, Leszczyńska-Bakal H, Pawlak E, Smazyński T (1976). "Gel with nystatin for treatment of lung mycosis". Polish Journal of Pharmacology and Pharmacy. 28 (4): 349–352. PMID 981024.
  25. ^ Espinel-Ingroff A (2003). Medical mycology in the United States: a historical analysis (1894-1996). Springer. p. 62.
  26. ^ Kelly K (2010). Medicine Becomes a Science: 1840-1999. Infobase. p. 71. ISBN 978-1-4381-2752-1. Archived from the original on 23 March 2017.
  27. ^ Sicherman B, Green CH (1980). Notable American Women: The Modern Period : a Biographical Dictionary. Belknap Press of Harvard University Press. p. 327. ISBN 978-0-674-62733-8. Archived from the original on 23 March 2017.
  28. ^ Brommelle NS (1970). "The Restoration of Damaged Art Treasures in Florence and Venice". Journal of the Royal Society of Arts. 118 (5165): 260–269. ISSN 0035-9114. JSTOR 41370578.
  29. ^ Akaike N, Harata N (1994). "Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms". The Japanese Journal of Physiology. 44 (5): 433–473. doi:10.2170/jjphysiol.44.433. PMID 7534361.
  30. ^ Korn SJ, Marty A, Connor JA, Horn R (1 January 1991), Conn PM (ed.), "[22] - Perforated Patch Recording", Methods in Neurosciences, Electrophysiology and Microinjection, vol. 4, Academic Press, pp. 364–373, doi:10.1016/B978-0-12-185257-3.50027-6, ISBN 9780121852573, retrieved 9 December 2023
  31. ^ Rognlien KT, Woodbury DJ (1 January 2003), Tien HT, Ottova-Leitmannova A (eds.), "Chapter 16 - Reconstituting SNARE proteins into BLMs", Membrane Science and Technology, Planar Lipid Bilayers (BLMs) and Their Applications, vol. 7, Elsevier, pp. 479–488, doi:10.1016/S0927-5193(03)80040-2, ISBN 9780444509406, retrieved 9 December 2023
  32. ^ Coutinho A, Prieto M (May 2003). "Cooperative partition model of nystatin interaction with phospholipid vesicles". Biophysical Journal. 84 (5): 3061–3078. Bibcode:2003BpJ....84.3061C. doi:10.1016/s0006-3495(03)70032-0. PMC 1302868. PMID 12719237.
  33. ^ "Nyata 100,000 Unit/Gram Topical Powder - Uses, Side Effects, and More". WebMD LLC. Retrieved 11 November 2018.

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土库曼斯坦总统土库曼斯坦国徽土库曼斯坦总统旗現任谢尔达尔·别尔德穆哈梅多夫自2022年3月19日官邸阿什哈巴德总统府（Oguzkhan Presidential Palace）機關所在地阿什哈巴德任命者直接选举任期7年，可连选连任首任萨帕尔穆拉特·尼亚佐夫设立1991年10月27日 土库曼斯坦土库曼斯坦政府与政治 国家政府 土库曼斯坦宪法 国旗 国徽 国歌 立法機關（英语：National Council of Turkmenistan） ...

 

 

Colin Blakemore

British neurobiologist (1944–2022) SirColin BlakemoreFRS FMedSci HonFRCP HonFRSM FRSB FBPhSBlakemore in 2012BornColin Brian Blakemore(1944-06-01)1 June 1944Stratford-upon-Avon, EnglandDied27 June 2022(2022-06-27) (aged 78)Oxford, EnglandAlma mater University of Cambridge (MA) University of California, Berkeley (PhD) Spouse Andrée Elizabeth Washbourne ​ ​(m. 1965; died 2022)​[2]Children3, including Sarah-Jayne...

EPodunk

Website ePodunkType of sitemedia ContentHeadquartersEl Segundo, CaliforniaParentInternet BrandsURLhttp://www.ePodunk.com ePodunk was a website that profiled communities in the United States, Canada, Ireland, and the UK. It provided geocoded information that includes local museums, attractions, parks, colleges, libraries, cemeteries and other features, as well as local history and trivia. The site contained vintage postcards that its users could send online.[1] The site became defunct ...

 

 

Video Game High School

American web series VGHS redirects here. For other uses, see VGHS (disambiguation). Video Game High SchoolAlso known asVGHSGenreAction comedy, science fictionCreated by Matthew Arnold Freddie Wong Will Campos Brian Firenzi Written by Matthew Arnold Will Campos Brian Firenzi Directed by Matthew Arnold Brandon Laatsch (Season 1) Freddie Wong Starring Josh Blaylock Johanna Braddy Brian Firenzi Nathan Kress Ellary Porterfield Cynthia Watros Jimmy Wong Country of originUnited StatesOriginal langua...

 

 

Gymnastics at the 2013 Summer Universiade

Gymnasticsat the XXVII Summer UniversiadeVenueGymnastics CentreDatesJuly 7, 2013 (2013-07-07) – July 10, 2013 (2013-07-10)←20112015→ Gymnastics was contested at the 2013 Summer Universiade from July 7 to 10 at the Gymnastics Centre in Kazan, Russia. Artistic and rhythmic gymnastics was the two disciplines of gymnastics contested.[1][2] Combined Medal table RankNationGoldSilverBronzeTotal1 Russia (RUS)*1883292 Japan (JPN)...

Eutrophication

Excessive plant growth in water This article is about a process in aquatic ecosystems. For one of the main causes, see nutrient pollution. For one of the effects, see harmful algal bloom. Eutrophication can cause harmful algal blooms like this one in a river near Chengdu, China. Part of a series onPlankton Trophic mode Phytoplankton Zooplankton Mixoplankton Mycoplankton Bacterioplankton Virioplankton By size Heterotrophic picoplankton Microalgae Microzooplankton Nanophytoplankton calcareous P...

 

 

Johnny Morales

Pour les articles homonymes, voir Moralès et Aquino (homonymie). Cet article est une ébauche concernant un coureur cycliste guatémaltèque. Vous pouvez partager vos connaissances en l’améliorant (comment ?). Pour plus d’informations, voyez le projet cyclisme. Johnny Morales AquinoInformationsNaissance 2 avril 1983 (41 ans)Nationalité guatémaltèquePrincipales victoires Champion du Guatemala sur route 2005modifier - modifier le code - modifier Wikidata Johnny Morales Aquin...