in more than one way. Nephrotoxins are substances displaying nephrotoxicity. Nephrotoxicity should not be confused with some medications predominantly excreted...

(seronegative) rheumatoid arthritis or ankylosing spondylitis. Fluoride induced nephrotoxicity is kidney injury due to toxic levels of serum fluoride, commonly due...

Drug Administration withdrew it from the market, due to reports of nephrotoxicity and hepatotoxicity. As of April 2025, it is used in New Zealand, Australia...

properties towards kidneys (nephrotoxicity). This is likely due to the Caleicine in the plant being metabolised into the nephrotoxic compound Eugenol that can...

factor for upper-extremity deep-vein thrombosis. Damage to the kidneys (nephrotoxicity) and to the hearing (ototoxicity) were side effects of the early, impure...

enhancing the efficacy of certain medications or reducing drug-induced nephrotoxicity, and potential risks, including unwanted drug accumulation and altered...

"Cisplatin nephrotoxicity". In: UpToDate, Palevsky PM (Ed), UpToDate, Waltham, MA, 2013. http://www.uptodate.com/contents/cisplatin-nephrotoxicity Robinson...

1984. Cisplatin has a number of side effects that can limit its use: Nephrotoxicity (kidney damage) is the primary dose-limiting side effect and is of major...

risk can be minimized by reducing the duration of use. Amikacin causes nephrotoxicity (damage to the kidneys), by acting on the proximal renal tubules. It...

of the most nephrotoxic drugs of this class. Oftentimes, acute nephrotoxicity is reversible, but it may be fatal. The risk of nephrotoxicity can be affected...

consistent with findings from earlier studies. Other precautions include nephrotoxicity, sulfonamide (sulfa) allergy, and increased free thyroid hormone effects...

abortion Ochratoxin Aspergillus ochraceus, Penicillium verrucosum nephrotoxicity, mild liver damage, immune suppression Ergot alkaloid Claviceps purpurea...

2017. Retrieved 31 August 2017. Luciano RL, Perazella MA (June 2014). "Nephrotoxic effects of designer drugs: synthetic is not better!". Nature Reviews...

individuals. Other side effects include nephrotoxicity, neuromuscular toxicity, and hypersensitivity reactions. Nephrotoxicity can be particularly worrisome when...

infections (including Clostridioides difficile), and kidney damage (nephrotoxicity). A rare, though less understood, side effect of the PPI class is the...

Escherichia coli The main toxicities described with intravenous treatment are nephrotoxicity (damage to the kidneys) and neurotoxicity (damage to the nerves), but...

the formula HCOOLi, and a molar mass of 51.95 g/mol. It is potentially nephrotoxic. Lithium formate crystalises in the orthorhombic crystal system, with...

approx. 0.03–0.1%. Of particular interest is the lower incidence of nephrotoxicity, compared with iodinated agents, when given at usual doses—this has...

auranthine has been reported. MacGeorge, K. M; Mantle, P. G (1990). "Nephrotoxicity of Penicillium aurantiogriseum and P. Commune from an endemic nephropathy...

prevent this nephrotoxicity. Hypersensitivity to cidofovir or probenecid (as probenecid needs to be given concurrently to avoid nephrotoxicity). It is known...

Souad (September 2, 2015). "Damascenine induced hepatotoxicity and nephrotoxicity in mice and in vitro assessed human erythrocyte toxicity". Interdisciplinary...

kidneys; these are prescribed only in severe infections where the risk of nephrotoxicity is preferable to the consequences of the infection. Adverse effects...

investigation into potential correlation of sevoflurane use and renal damage (nephrotoxicity). However, this should be subject to further investigation, as a recent...

does not flow from the liver to the intestine) and liver fibrosis. Nephrotoxicity (kidney damage) can be caused by tumor lysis syndrome and also due direct...

little oral toxicity. However, synthetic soluble germanium salts are nephrotoxic, and synthetic chemically reactive germanium compounds with halogens...

individual. Clinical cardiotoxicity is not widely observed, nor is nephrotoxicity present among patients bitten by this species, presumably due to the...

Investigation. 64 (4): 546–56. PMID 1673163. Tulkens, P.M. (March 1989). "Nephrotoxicity of aminoglycoside antibiotics". Toxicology Letters. 46 (1–3): 107–123...

liposomal nystatin appears to cause fewer cases of and less severe nephrotoxicity than observed with amphotericin B. Bitter taste and nausea are more...

risk of further renal damage such as beginning medications with known nephrotoxicity. In 1666, Italian biologist and anatomist Marcello Malpighi first described...

Aihua (11 June 2019). "Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms". Frontiers in Pharmacology...

should be used with caution in patients with colitis, as it is both nephrotoxic and ototoxic. Absorption through the damaged wall of the intestinal tract...

candidiasis, pseudomembranous colitis, superinfection, eosinophilia, nephrotoxicity, neutropenia, thrombocytopenia, and fever.[citation needed] The commonly...

Minostad 50 mg-Kapseln. "Principles and methods for the assessment of nephrotoxicity associated with exposure to chemicals". Environmental health criteria...

patients who might be at risk of nephrotoxicity, although all preparations of amphotericin B have a risk of nephrotoxicity. Individuals on amphotericin B...

use of tenofovir disoproxil is associated with nephrotoxicity and bone loss. Presentation of nephrotoxicity can appear as Fanconi syndrome, acute kidney...

inhibitor of COX-2 byproducts, particularly prostaglandins. It may be less nephrotoxic than indomethacin. There are two known polymorphs of the compound. Nabumetone...

RT, Badaró R (June 2012). "Does lipid emulsion reduce amphotericin B nephrotoxicity? A systematic review and meta-analysis". Clinical Infectious Diseases...

of toxicity that have been studied for citrinin are acute toxicity, nephrotoxicity, genotoxicity and its carcinogenicity. The acute toxicity of citrinin...

alternative to glycerine for industrial applications. Diethylene glycol is nephrotoxic and can result in multiple organ dysfunction syndrome (MODS), especially...

making Champagne. Along with grapes and raisins, Zante currants are nephrotoxic to dogs. This toxicity manifests as kidney failure and can be seen in...

pigs in large amounts over several days. Such forage may cause fatal nephrotoxicity, presumably because of its high oxalate content. Other symptoms, such...

resulting in numerous adverse effects including bone marrow suppression, nephrotoxicity, abnormal heart rhythm, rhabdomyolysis, hypotension, gastrointestinal...

36. doi:10.2460/javma.2002.220.49. PMID 12680447. Hall J (1992). "Nephrotoxicity of Easter Lily (Lilium longiflorum) when ingested by the cat". Proc...

older platinum-based drugs, avoiding the dose-limiting side-effect of nephrotoxicity. Oxalic acid and oxalates can be oxidized by permanganate in an autocatalytic...

risk of harmful or even dangerous effects (gastrointestinal bleeding, nephrotoxicity), increased from 17 to 43. The interaction between citrus and medication...

strains can be treated by gentamicin and ampicillin antibiotics. A less nephrotoxic combination of ampicillin and ceftriaxone (even though E. faecalis is...

action on the kidneys is not fully understood, but may be due in part to nephrotoxic metabolites of myoglobin.[citation needed] Chronic kidney failure has...

36. doi:10.2460/javma.2002.220.49. PMID 12680447. Hall J (1992). "Nephrotoxicity of Easter Lily (Lilium longiflorum) when ingested by the cat". Proc...

an aminoglycoside, it can increase the possibility of ototoxicity, nephrotoxicity and neuromuscular blockage, result in some hearing loss or can continue...

primary agent) is known to be associated with increased drug-induced nephrotoxicity impairing kidney function. Other formulations have been developed such...

reduced ejection fraction. Potential side effects include angioedema, nephrotoxicity, and low blood pressure. It was approved for medical use in the United...

include nausea and vomiting, hair loss, tinnitus, hearing loss, and nephrotoxicity.) Organoplatinum compounds such as the above anti-tumor agents, as well...

cidofovir without apparent nephrotoxicity. Nephrotoxicity is a major concern for this drug. IVIG is expensive, nephrotoxic (due to osmosis) and requires...

poisoning". Batrachotoxin Cytotoxicity Multiple chemical sensitivity Nephrotoxicity Ototoxicity Penitrem A Excitotoxicity Toxicity Cunha-Oliveira, Teresa;...

and is rapidly eliminated from the lungs. It is not associated with nephrotoxicity and is resistant to defluorination. It is carried by albumin in the...

intravenously. Nephrotoxicity: Like cisplatin, nephrotoxicity, harm to the kidneys, is the primary dose-limiting factor. However, the nephrotoxicity of nedaplatin...

hypertension, blurred vision, liver and kidney problems (tacrolimus nephrotoxicity), hyperkalemia, hypomagnesemia, hyperglycemia, diabetes mellitus, itching...

it by painful intramuscular injection Serious side effects include nephrotoxicity and hypertension. Dimercaprol has been found to form stable chelates...

cholesterol, increasing the risk of human toxicity. Amphotericin B is nephrotoxic when given intravenously. As a polyene's hydrophobic chain is shortened...

of the urine, believed to reduce the breakdown of myoglobin into its nephrotoxic metabolites, thus preventing renal damage. Often, IV normal saline is...

However, no apparent effect is seen on pre-existing methotrexate-induced nephrotoxicity. While not specifically an antidote for methotrexate, folinic acid may...

Preeti; Chowdhuri, Soumeek; Mukhopadhyay, Partha Pratim (2018-01-29). "Nephrotoxicity in krait bite: a rare case series of three fatalities in consecutive...

oxidase activity and methylglyoxal levels in aristolochic acid-induced nephrotoxicity". Life Sciences. 114 (1): 4–11. doi:10.1016/j.lfs.2014.07.034. Nchinech...

adverse reactions are possible, including Steven Johnson syndrome, nephrotoxicity, hepatitis, aplastic anemia, neutropenia, or agranulocytosis. More common...

rheumatoid arthritis; Kawasaki's disease GI bleeds; ulcers; Reye syndrome; nephrotoxicity; blood dyscrasias (rarely); Stevens–Johnson syndrome (uncommon/rare)...

catalysts to this reaction. While dichloroacetylene is nephrotoxic in rats, its nephrotoxicity in humans is not well-understood. Dichloroacetylene has...

injected in large doses; precipitation of this hydroxide resulted in nephrotoxicity in animals. In lower doses, soluble gallium is tolerated well and does...

rotunda contains aristolochic acids which are carcinogenic, mutagenic, and nephrotoxic. Plants of Aristolochia rotunda Flower of Aristolochia rotunda The small...

In horses, this includes gastric ulcers, right dorsal colitis, and nephrotoxicity. Flunixin is a prohibited substance under International Federation for...

prior normal renal function, this can result in neurotoxic as well as nephrotoxic effects. In Malaysia, very acidic bilimbis are used to clean kris blades...

"Does prolonged oral exposure to cyanide promote hepatotoxicity and nephrotoxicity?". Toxicology. 174 (2): 87–95. Bibcode:2002Toxgy.174...87S. doi:10...

of the side effects to these drugs include nausea, hearing loss, and nephrotoxicity. Handling of these drugs by medical personal also led to side effects...

heart failure are quite frequent. Kidney: 25 percent develop signs of nephrotoxicity ranging from mild, asymptomatic azotemia (increased serum creatinine...

necrosis and degeneration have been observed. The hepatotoxicity and nephrotoxicity of chloroform is thought to be due largely to phosgene, one of its metabolites...

hydrolyzed in the mammalian kidney by a dehydropeptidase enzyme to a nephrotoxic intermediate, and thus is co-formulated with the dehydropeptidase inhibitor...

was an effective agent; however, it was associated with unacceptable nephrotoxicity and agranulocytosis. It was proposed that the toxicity arose from the...

gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic". Clinical Infectious Diseases. 48 (6): 713–21. doi:10.1086/597031. PMID 19207079...

side effects include changes in the menstrual cycle, neuropathy, and nephrotoxicity. Checkpoint inhibitor (immunotherapy) side effects commonly include...

Sprando RL (2016). "Evaluation of "Dream Herb," Calea zacatechichi, for Nephrotoxicity Using Human Kidney Proximal Tubule Cells". J Toxicol. 2016 9794570....

was an effective agent; it was associated, however, with unacceptable nephrotoxicity and agranulocytosis. The toxicity was proposed to arise from the thiourea...

"Successful rescue in a patient with high dose methotrexate-induced nephrotoxicity and acute renal failure". Leukemia & Lymphoma. 29 (1–2): 205–9. doi:10...

demonstrated, but it was almost never used after it was found to cause nephrotoxicity in a number of patients. However, it was then realized that it was possible...

another low-toxicity substance), it will form an insoluble and rather nephrotoxic complex, as evidenced in dogs and cats during the 2007 pet food contamination...

toxic gases Material safety data sheet (MSDS) Mutagen Hepatotoxicity Nephrotoxicity Neurotoxicity Ototoxicity Paracelsus Physiologically-based pharmacokinetic...

Control. Retrieved 12 March 2014. Wolinsky, Hines (1962). "Neurotoxic and nephrotoxic effects of colistin in patients with renal disease". www.nejm.org. doi:10...

Masashi; Ito, Yasuhiko; Morgan, B. Paul (23 July 2012). "Exploiting the Nephrotoxic Effects of Venom from the Sea Anemone, Phyllodiscus semoni, to Create...

in zero-time biopsy is a risk factor for tacrolimus-induced chronic nephrotoxicity". Nephrology (Carlton). 20 Suppl 2: 51–7. doi:10.1111/nep.12461. PMID 26031587...

hydrophilic moiety attached to enhance tissue distribution and reduce nephrotoxicity. Vancomycin was isolated in 1953 and used clinically by 1958, while...

Naesens M, Kuypers DR, Sarwal M (February 2009). "Calcineurin inhibitor nephrotoxicity". Clinical Journal of the American Society of Nephrology. 4 (2): 481–508...

Sjogren syndrome Dehydration / low blood volume Cardiovascular disease Nephrotoxic medications Infections Urinary tract obstruction In all cases, the result...

role in chemical toxicity susceptibility and identified biomarkers of nephrotoxicity from therapeutic drugs. Additionally, he applied computational toxicology...

(English: /əˌrɪstəˈloʊkɪk/) are a family of carcinogenic, mutagenic, and nephrotoxic phytochemicals commonly found in the flowering plant family Aristolochiaceae...

p. 267 Ekong EB, Jaar BG, Weaver VM (December 2006). "Lead-related nephrotoxicity: a review of the epidemiologic evidence". Kidney International. 70 (12):...

found to increase the plasma concentrations of methotrexate, as have nephrotoxic agents such as cisplatin, the GI drug colestyramine, and dantrolene....

This is more common in women. Oxaliplatin has less ototoxicity and nephrotoxicity than cisplatin and carboplatin. The compound features a square planar...

overgrowth. Neomycin is not administered via injection, as it is extremely nephrotoxic (damaging to kidney function) even when compared to other aminoglycosides...

may also cause kidney impairment, especially in combination with other nephrotoxic agents. Kidney failure is especially a risk if the patient is also concomitantly...

panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity. Panipenem/betamipron Finch RG (2003). Antibiotic and chemotherapy:...

cisplatin derivative with broad antitumour activity and comparatively less nephrotoxicity. A second group with an NCI contract, led by John Montgomery at the...

are a group of kidney disorders that present with kidney damage due to nephrotoxic monoclonal immunoglobulins (M proteins) secreted by clonal plasma cells...

leaves themselves contain notable quantities of oxalic acid, which is a nephrotoxic and corrosive acid present in many plants. Symptoms of poisoning include...

Chemical Elements, Reinhold, New York, pp. 73–81 Schauss AG 1991, 'Nephrotoxicity and Neurotoxicity in Humans from Organogermanium Compounds and Germanium...

cholangitis. The treatment-related adverse effects include hepatotoxicity, nephrotoxicity, hemolysis, and interactions with other drugs. For those reasons as...

even among patients with comorbidities reported to predispose them to nephrotoxicity. Moreover, hydration, the most established prevention measure to prevent...

(42.42% of patients). Most major toxicities of cisplatin, especially nephrotoxicity, were also reduced in the group of patients treated with lipoplatin...

PMID 27900734. Davis J, Desmond M, Berk M (November 2018). "Lithium and nephrotoxicity: a literature review of approaches to clinical management and risk stratification"...

Early generations of intravenous (IV) contrast carried considerable nephrotoxicity, necessitating continual assessment of renal function. IV and PO (per...

patient, including cardiac toxicity, sepsis, pulmonary failure, and nephrotoxicity, among others. Chronic consequences of the treatment included development...

MS (Aug 17, 2009). "Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2--a global assessment based on bibliographic...

aminoglycoside and tetracycline families need to be avoided due to their nephrotoxicities. The antibiotics of choice are penicillins, clindamycin, and cephalosporins...

mesylate – neoadjuvant therapy – neoplasia – neoplasm – nephrotomogram – nephrotoxic – nephroureterectomy – nerve block – nerve grafting – nerve-sparing radical...

level of 1.1 mg/m2. Diarrhea was treatable with loperamide. Lack of nephrotoxicity and low urinary excretion supported use of drug without hydration. Tesoriero...

on the kidneys is not understood completely, but may be due partly to nephrotoxic metabolites of myoglobin. The most devastating effects upon the body...

industry standard." A 2016 study reported that metals can be carcinogenic, nephrotoxic, neurotoxic, and hemotoxic. A 2018 study reported that copper nanoparticles...

the body via dermal contact; long-term usage has been found to cause nephrotoxicity and benzene-induced leukemia in the bone marrow. A study by Pascal del...

gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic". Clinical Infectious Diseases. 48 (6): 713–721. doi:10.1086/597031....

prevents endotoxin from binding to inflammatory cells, but is potentially nephrotoxic, so should be used with caution in horses with azotemia, especially neonatal...

correlated to reduced risk of cholesterol problems, cancer, and heavy metal nephrotoxicity. Spirulina is relatively popular among dietary supplement enthusiasts...

fumaric acid is "practically non-toxic" but high doses are probably nephrotoxic after long-term use. Fumaric acid was developed as a medicine to treat...

Zbinden G, Brändle E (February 1980). "Inhibition of 5-hydroxytryptophan nephrotoxicity by alpha-difluoromethyl-dopa, an inhibitor or L-amino acid decarboxylase"...

proteins in urine as a consequence of metal accumulation. Penicillin is nephrotoxic in people with kidney failure, and captopril can aggravate proteinuria...

Khandar, Ali Akbar; Salehi, Roya; et al. (December 2019). "In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes". Scientific...

extensive side effect profile, including skin photosensitivity, and nephrotoxicity. Urea: oral daily ingestion has shown favorable long-term results with...

and Cotard's syndrome. Intravenous aciclovir may cause reversible nephrotoxicity in up to 5% to 10% of patients because of precipitation of aciclovir...

bacteria, but their intravenous clinical use has been limited due to their nephrotoxicity and neurotoxicity side effects. The extracorporeal use of the Toraymyxin...

carboplatin is its reduced side effects, particularly the elimination of nephrotoxic effects. Nausea and vomiting are less severe and more easily controlled...

ethylene oxide, which is hazardous. Ethylene glycol and its ethers are nephrotoxic (poisonous to the kidneys) if applied to damaged skin. The United States...

many parts of the world. Still, the relatively frequent occurrence of nephrotoxicity and ototoxicity during aminoglycoside treatment makes physicians reluctant...

PMC 1884162. PMID 17511865. "Principles and methods for the assessment of nephrotoxicity associated with exposure to chemicals". Environmental health criteria:...

Naesens M, Kuypers DR, Sarwal M (February 2009). "Calcineurin inhibitor nephrotoxicity" (PDF). Clinical Journal of the American Society of Nephrology. 4 (2):...

therapeutic index. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin...

increased toxicity since oxidative stress cannot be reduced. In addition, nephrotoxicity is augmented by deficiency of selenium or tocopherol. The pyridinium...

include nausea and vomiting, diarrhoea, hypersensitivity reactions, nephrotoxicity, convulsions, CNS toxicity, hepatic dysfunction, haematologic disorders...

Joiner; Suki, Wadi N. (2006-09-01). "Are Gadolinium-Based Contrast Media Nephrotoxic?: A Renal Biopsy Study". Archives of Pathology & Laboratory Medicine...

tanzawaic acid A-D, ACC, Mevastatin, Quinocitrinine A, Quinocitrinine B, and nephrotoxic citrinin. Penicillium citrinum is often found on moldy citrus fruits...

the mushroom C. orellanus. Grzymala was also able to demonstrate the nephrotoxicity of C. orellanus and determine various physical and chemical properties...

used in CT and the main adverse events are anaphylactoid reactions and nephrotoxicity. Commonly used MRI contrast agents have a good safety profile, but linear...

medications that are cleared by the kidneys. Some of the most commonly used nephrotoxic medications are non-steroidal anti-inflammatory drugs (NSAIDs) such as...

original on June 6, 2013. Cox M (1982). "Tetracycline Nephrotoxicity". In Porter GA (ed.). Nephrotoxic Mechanisms of Drugs and Environmental Toxins. Boston...

the circulatory changes in blood flow as well as possible exposure to nephrotoxic medications, iodine contrast agents, and long term cyanotic and ischemic...

side effects include changes in the menstrual cycle, neuropathy, and nephrotoxicity. Radiation therapy (RT) adverse effects; for a complete side effect...

increase serum transaminases; liver tests should be monitored periodically Nephrotoxicity Can increase serum creatinine levels; renal function should be monitored...

1440-1665.2004.02137.x. PMID 15715818. Alansari M, Hamilton D (May 2006). "Nephrotoxicity of BZP-based herbal party pills: a New Zealand case report". The New...

and betamipron inhibits renal uptake of panipenem and so reduces its nephrotoxicity (much like the imipenem/cilastatin combination). Hikida M, Terashima...

[citation needed] Nephrotoxicity — increase in serum creatinine levels and renal injury can occur in patients receiving foscarnet. Other nephrotoxic drugs should...

agents (e.g. cisplatin). It is also used to decrease the cumulative nephrotoxicity associated with platinum-containing agents. Amifostine is also indicated...

thus preventing further degradation to oxalic acid and the associated nephrotoxic effects. The unreacted ethylene glycol remains in the body and is eventually...

"second malignant neoplasms, cardiovascular disease, neurotoxicity, nephrotoxicity, pulmonary toxicity, hypogonadism, decreased fertility, and psychosocial...

Failure Associated with Traumatic and Toxic Injury. Renal Ischemia, Nephrotoxic Damage and the Ischemuric Episode 1". J Clin Invest. 30 (12): 1307–439...

(September 2021). "Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice". Journal of Trace Elements in Medicine and Biology. 67 126798...

setting (link) Piscitani L, Sirolli V, Morroni M, Bonomini M (2020). "Nephrotoxicity Associated with Novel Anticancer Agents (Aflibercept, Dasatinib, Nivolumab):...

Richard, Jean-Michel; Louis, Josette; Cantin, Danielle (1 March 1988). "Nephrotoxicity of orellanine, a toxin from the mushroom Cortinarius orellanus". Archives...

snakes. Sea snake venoms in humans are thus more often myotoxic and/or nephrotoxic rather than neurotoxic. Sea snakes were at first regarded as a unified...

49–52. doi:10.2460/javma.2002.220.49. PMID 12680447. Hall, J. (1992). "Nephrotoxicity of Easter Lily (Lilium longiflorum) when ingested by the cat". Proc...

contaminants. This can neutralize the toxicity of sepsis, but runs the risk of nephrotoxicity and neurotoxicity. The small size (< 100 nm) and large surface area...

OCLC 896796140. Ahmadizadeh, M.; Kuo, C.-H.; Hook, J.B. (1981-07-01). "Nephrotoxicity and hepatotoxicity of chloroform in mice: Effect of deuterium substitution"...

contamination and the species. Germanium dioxide has low toxicity, but it is nephrotoxic in higher doses.[citation needed] Germanium dioxide is used as a germanium...

In addition to its carcinogenicity, aristolochic acid is also highly nephrotoxic and may be a causative agent in Balkan nephropathy. However, despite...

migraine relief or recurrence . Long term NSAID use has risks including nephrotoxicity and cardiotoxicity, and long term acetaminophen use is associated with...

nephrotoxicity and can result in iatrogenic damage to the newly transplanted kidney. Tacrolimus, which is a similar drug, also causes nephrotoxicity....

Like zeniplatin and carboplatin, use of enloplatin causes manageable nephrotoxicity, no significant neurotoxicity or ototoxicity, and dose-limiting myelosuppression...

blood pressure. Toxins in snake venom can also cause kidney damage (nephrotoxicity) via the same inflammatory cytokines. The toxins cause direct damage...

combination with live vaccines, chemotherapy or immunosuppressants. Nephrotoxicity could be increased when the drug is combined with aminoglycoside antibiotics...

8-dihydroxyadenine and with crystalluria, calculus formation, and potential nephrotoxicity. The condition primarily presents as renal obstructive disease, but...

Sabath-Silva, Elizabeth; Sabath, Ernesto (2015-04-21). "Arsenic-mediated nephrotoxicity". Renal Failure. 37 (4): 542–547. doi:10.3109/0886022X.2015.1013419...

Jing; Liang, Aihua (2019). "Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms". Frontiers in Pharmacology...

uterus. The obsolete (as an anaesthetic) agent methoxyflurane had a nephrotoxic effect and caused acute kidney injury, usually attributed to the liberation...

necrosis and enteritis. The mechanisms by which this fungus causes the nephrotoxicity in animals are cell apoptosis and lipid peroxidation. In the pig population...

inhibitor-free regimen, resulting in a mean HbA1c of 5.35% without evidence of nephrotoxicity or neurotoxicity typically associated with standard immunosuppressants...

encounter an obstacle in the form of damage to the auditory nerve and nephrotoxic effect. Wimmer T (2012). "Cyclodextrins". Ullmann's Encyclopedia of Industrial...

triggers a profound inflammatory response within liver cells. Nephrotoxicity: Nephrotoxicity, also known as kidney toxicity has been demonstrated in rat...

inflammatory bowel conditions. SOD may ameliorate cis-platinum-induced nephrotoxicity (rodent studies). As "Orgotein" or "ontosein", a pharmacologically-active...

used to quantify and localise renal tubular injury in transplantation, nephrotoxicity and ischaemic injury. In rodent pre-clinical studies, urinary and serum...

Pearson AD, English MW, et al. (1996). "Risk factors for ifosfamide nephrotoxicity in children". Lancet. 348 (9027): 578–80. doi:10.1016/S0140-6736(96)03480-0...

eosinophilia Thrombocytopaenia Liver necrosis Hepatitis Jaundice Hepatomegaly Nephrotoxicity Unknown frequency: Weight loss Abdominal cramps Hair loss Photosensitivity...

whose long-term use was associated with adverse side effects such as nephrotoxicity and bone density loss. Gilead's first TAF medication, marketed under...

( Pachycondyla sennaarensis ) Venom Protects against CCL 4 -Induced Nephrotoxicity in Mice". Oxidative Medicine and Cellular Longevity. 2014: 1–8. doi:10...

Jing; Liang, Aihua (2019). "Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms". Frontiers in Pharmacology...

Rosalinde (Feb 2016). "Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening". Trends in Biotechnology. 34 (2): 156–170. doi:10.1016/j...

monitored for hypertension (and treated for it if discovered) and avoid nephrotoxic drugs such as certain pain relievers and intravenous contrast agents...

typically administered parenterally.[citation needed] Ototoxicity and nephrotoxicity are the most serious adverse effects of aminoglycoside therapy and are...

Zongwei (1 September 2021). "Urinary metabolic characterization with nephrotoxicity for residents under cadmium exposure". Environment International. 154...

the Effect of an Aminoglycoside Dosing Regimen on Rates of Observed Nephrotoxicity and Ototoxicity". Antimicrobial Agents and Chemotherapy. 43 (7): 1549–1555...

leukoencephalomalacia. Effects of feeding rats with FB1 for up to 90 days were usually nephrotoxicity. Between different strains of rats, sensitivity to FB1 varied. In the...

effects or hypersensitivity reactions. While there is potential for nephrotoxicity and ototoxicity, the incidence of such organ toxicity is rare if recommended...

1016/0002-9343(77)90357-6. PMID 13653. Skinner R (2003). "Chronic ifosfamide nephrotoxicity in children". Med. Pediatr. Oncol. 41 (3): 190–7. doi:10.1002/mpo.10336...

techniques, such as being performed without radiation exposure and potential nephrotoxicity. Contrast echocardiography requires intravenous administration of an...

biocompatible contrast agent, meaning no adverse reactions, such as allergy, nephrotoxicity, and hepatotoxicity. Carbon dioxide is a negative contrast medium and...

long term are in higher risk of developing chronic renal diseases and nephrotoxicity due to reduced renal perfusion. As NSAIDs inhibit prostaglandin synthesis...

1016/S0378-4274(01)00534-3. PMID 11869818. Rosenberg LE, Hayslett JP (August 1967). "Nephrotoxic effects of penicillamine in cystinuria". JAMA. 201 (9): 698–699. doi:10...

1056/NEJMct0708278. PMC 2637612. PMID 18635433. Boutis K, Shannon M (2001). "Nephrotoxicity after acute severe acetaminophen poisoning in adolescents". Journal...

used as an alternative to aminoglycosides because it is not ototoxic or nephrotoxic. Reported side effects include injection site reactions, rash, and rarely...

may increase the risk of rejection. Certain medications may also have nephrotoxic or other potentially harmful side-effects. Other medications may also...

Paenibacillus polymyxa. Polymyxin antibiotics are relatively neurotoxic and nephrotoxic, so are usually used only as a last resort if modern antibiotics are...

BC, Adamson PC (June 2006). "Understanding and managing methotrexate nephrotoxicity". The Oncologist. 11 (6): 694–703. doi:10.1634/theoncologist.11-6-694...

particularly related. The FDA warns against consuming Asarum, as it is nephrotoxic and contains the potent carcinogen aristolochic acid. The birthwort family...

Jayarajah, Umesh; De Zoysa, Ishan; Seneviratne, Suranjith L (2021-09-03). "Nephrotoxicity and neurotoxicity following star fruit ( Averrhoa carambola ) ingestion:...

PMID 9257778. Atta MG, Fine DM (March 2009). "Editorial comment: tenofovir nephrotoxicity--the disconnect between clinical trials and real-world practice". AIDS...

ISBN 978-1-4939-3734-9. Principles and methods for the assessment of nephrotoxicity associated with exposure to chemicals. Environmental Health Criteria...

Cai, Zongwei (2021-09-01). "Urinary metabolic characterization with nephrotoxicity for residents under cadmium exposure". Environment International. 154...

non-diagnostic when used alone. Additionally, pyelograms use potentially nephrotoxic contrast agents, further limiting their utility. Diagnosis is primarily...

hypertension or hypotension, and hypoxia, and its chronic effect is nephrotoxicity. In 1999, an anticancer drug miltefosine was demonstrated to be highly...

to mammalian cells. This manifests itself mainly as hepatotoxicity, nephrotoxicity, and cardiotoxicity. Cardiotoxicity is a notable concern with tubercidin...

is called an onconephrologist. This branch of nephrology encompasses nephrotoxicity associated with existing and novel chemotherapeutics, kidney disease...

Microsoft Academic. Naesens, Maarten, et al. “Calcineurin Inhibitor Nephrotoxicity.” Clinical Journal of The American Society of Nephrology, vol. 4, no...

reprocessing. Like all water soluble uranium salts, uranium tetrachloride is nephrotoxic (poisonous to the kidney) and can cause severe renal damage and acute...

foscarnet is commonly accompanied by restrictive toxicity, particularly nephrotoxicity. If the virus also acquires resistance to foscarnet, then there is currently...

blood, in hemolysis requiring alkalinization of the urine to avoid nephrotoxicity of blood pigments, and certain drug intoxications, such as by barbiturate...

Common adverse events (≥20% incidence) include: Serious risks include nephrotoxicity, retinal toxicity, and embryo-fetal harm (contraindicated in pregnancy)...

testicular cancer and lymphomas. Myelosuppression, haemorrhagic cystitis, nephrotoxicity, neurotoxicity and cardiac toxicity (rare). Secondary malignancies....

Removal of ticks, symptomatic treatment and good nursing care. Non-nephrotoxic antibiotics and anti-inflammatory preparations are used for healing of...

species can also be toxic to humans, as it produces toxins that cause nephrotoxic effects, causing damage to the kidneys. Xanthium spinosum is classified...

calcineurin inhibitors (tacrolimus and ciclosporin) are significantly nephrotoxic. Thus, while some people with a pancreas transplant tolerate the immunosuppressive...

PMID 12606735. Atta MG, Fine DM (March 2009). "Editorial comment: tenofovir nephrotoxicity--the disconnect between clinical trials and real-world practice". The...

disrupting transcription and translation of the cell's DNA. Kidney damage (nephrotoxicity) in the form of proximal tubular injury is the main reason to stop cisplatin...

Tricyclic antidepressants - idiosyncratic Mycotoxins Hepatotoxicity Nephrotoxicity Neurotoxicity Ototoxicity Myelotoxicity Vardanyan, R. S., and Victor...

kidney complications, preferably elect to manage the patient with non-nephrotoxic medications when and if necessary. Additionally, use diuretics sparingly...

ingested, and absorbed through skin. Lithium exposure is known to be nephrotoxic, thyrotoxic, and causes birth defects. As mining of these minerals expands...

2025). "GV1001, an hTERT-Derived Peptide, Prevents Cisplatin-Induced Nephrotoxicity by Preserving Mitochondrial Function". Cells. 14 (22): 1818. doi:10...

Cai, Zongwei (2021-09-01). "Urinary metabolic characterization with nephrotoxicity for residents under cadmium exposure". Environment International. 154...

reactions. Others: gynecomastia in men. Overdose. Symptoms: neuro- and nephrotoxicity. Treatment: gastric lavage, symptomatic therapy. Ranitidine and bismuth...

(March 2019). "Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer". The Cochrane Database of Systematic...

Secondly the nephrotoxicity and hepatotoxicity of the semustine cause pulmonary fibrosis and renal dysfunction. Semustine nephrotoxicity is cumulative...

the uranium(IV) acetate (U(OAc)4). In general, uranium salts exhibit nephrotoxicity. Normal commercial stocks from depleted uranium have typical specific...

dental amalgam suggest that mercury from dental amalgam may lead to nephrotoxicity, neurobehavioural changes, autoimmunity, oxidative stress, autism, skin...

and nitrosoureas, can cause renal and metabolic problems due to their nephrotoxic effects. These medications may also cause renal failure or certain kidney...

metabolism leads to the formation of reactive metabolites which can lead to nephrotoxicity and neurotoxicity. GRCm38: Ensembl release 89: ENSMUSG00000039648 –...

cardiomyocytes (cardiotoxicity model), kidney proximal tubule epithelial cells (nephrotoxicity model), astrocytes (neurotoxicity model), endothelial cells (vascular...

people with CMV resistant to ganciclovir, because foscarnet has notable nephrotoxicity, resulting in increased or decreased Ca2+ or PO43−, and decreased Mg2+...

developing lithium intoxication. The drug itself is also known to be nephrotoxic, opening up the possibility of spontaneous emergence of toxicity at doses...

positive effects on nematodes, it is extra poisonous to cats. It causes nephrotoxicity and acute renal failure, but at what dose exactly is not known. Symptoms...

(March 2019). "Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer". The Cochrane Database of Systematic...

Rush GF, Hook JB (1988). "Biochemical mechanisms of cephaloridine nephrotoxicity". Life Sciences. 42 (19): 1809–16. doi:10.1016/0024-3205(88)90018-5...

T; Frisvad, J C; Seifert, K A; Abramson, D (1995). "Identification of Nephrotoxic Penicillium Species from Cereal Grains". Mycotoxin Research. 11 (1):...

oxidative stress. In a small rat study, the off-target effects of cisplatin—nephrotoxicity arising from its induction of pathways that generate reactive oxygen...

intrinsically less bowel movements, and often have antihypertensive or nephrotoxic drugs. It is also reported that people with comorbidities including diabetes...

trapidil, an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats". Pharmacological Research. 44 (4): 321–328. doi:10.1006/phrs...

engaged in a number of biomarker R&D programmes for acute kidney injury (nephrotoxicity) and acute liver injury (hepatotoxicity) detection. Argutus Medical...

patients. Following surgery, the test can help predict the risk of nephrotoxicity from these drugs and assess graft function. Outside of transplantation...

viral-like illness. This may be complicated by acute renal failure due to nephrotoxic free hemoglobin and tubular obstruction. Although the disease may be...

Minghua; Li, Juan; Li, Jinhua (2023-03-03). "Investigation of the nephrotoxicity of 2,6-dichloro-1,4-benzoquinone disinfection by-product in mice through...

doi:10.1021/jm00107a034. PMID 1900533. Everett RM, et al. (1993). "Nephrotoxicity of pravadoline maleate (WIN 48098-6) in dogs: evidence of maleic acid-induced...

ferritin molecular transporters are affected. This may ultimately lead to nephrotoxicity, reproductive and developmental toxicity due to tissue damage, necrosis...

and bone marrow transplant (BMT)) have placed more patients at risk of nephrotoxic therapies and medication leading to a spike in secondary AKI (mentioned...

Durham S, Miller R, Davis C, Shepler BM (May 20, 2010). "Bisphosphonate Nephrotoxicity Risks and Use in CKD Patients". U.S. Pharmacist. 35 (5). Dahiya N, Khadka...

"Species Differences in Renal Development and Associated Developmental Nephrotoxicity". Birth Defects Research. 109 (16): 1243–1256. doi:10.1002/BDR2.1088...

pregnancy or planned pregnancy breast-feeding liver problems kidney problems nephrotoxic drugs hepatotoxic drugs By intravenous infusion. Dosage is a 2-hour infusion...

reported in the literature include Hepatotoxicity: elevated transaminases Nephrotoxicity: acute kidney injury from rhabdomyolysis Also, myopathy and rhabdomyolysis...

patient, and magnetic resonance angiography (MRA), which avoids X-rays and nephrotoxic contrast agents. Angiography Computed tomography angiography (CTA) Contrast...

toxicity; these effects are observed only at higher doses. Furthermore, the nephrotoxicity of dicycloplatin is reported to be less than that of cisplatin, and...

diseases. It was a standard care for a range of pathogenic fungus, however nephrotoxicity and infusion-related reactions was a major constraint. Kshirsagar and...

relief; rarely used for chronic pain or as an anesthetic because of nephrotoxicity risks. Enflurane C3H2ClF5O Induction and maintenance of general anesthesia...

or more). Additionally, to prevent reversible aminopterin-mediated nephrotoxicity manifesting as increases in serum creatinine and which further delays...

less severe gingival overgrowth than cyclosporin, but is similarly as nephrotoxic. The dihydropyridine derivative isradipidine can replace nifedipine for...

Lomustine use is linked to a variety of organ toxicities hepatotoxicity, nephrotoxicity, and pulmonary toxicity. Hepatotoxicity occurs due to increased levels...

in inhibiting phosphorylation. There is also a known interaction with nephrotoxic or bone marrow suppressive agents (e.g. doxorubicin) which increases...

resulting in chills and muscle pain but can also include severe forms of nephrotoxicity. Amphotericin B binds to ergosterol, found in fungal cell membranes...

secondary metabolite and mycotoxin characterized by its hepatotoxicity, nephrotoxicity and cytotoxicity. Sclerin, a compound which stimulates plant growth...

dose MTX. While IV HD-MTX poses higher risks of hepatotoxicity and nephrotoxicity, IT-MTX also leads to adverse effects characteristic of Ommaya reservoir...

due to studies showing that the acids are carcinogenic, mutagenic, and nephrotoxic, thus causing much more harm than good. Although they do not smell pleasant...

PPRHs do not have off-target effects and do not show hepatotoxicity or nephrotoxicity. PPRHs could be used as gene silencing tools acting by different mechanisms...

organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity". American Journal of Physiology. Renal Physiology. 296 (6): F1307–F1313...

HIV-1. Despite its use in medicine, cyclosporine A exhibits significant nephrotoxicity, cardiotoxicity, and hepathotoxicity. Drugs containing T. inflatum-produced...

ceftolozane/tazobactam with other renally eliminated medications due to possible nephrotoxicity Ceftolozane–tazobactam is available as a 2:1 fixed combination (such...

to play a role in the development of nephrotoxic acute kidney injury (AKI) by mediating the uptake of nephrotoxic agents. However, there have been no further...

2019). "Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity". American Journal of Physiology. Renal Physiology. 317 (1): F107–F115...

; Adamson, Peter C. (15 May 2004). "High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma". Cancer. 100 (10): 2222–2232. doi:10...

known. In October, the results of the "AAVLD survey of pet food-induced nephrotoxicity in North America, April to June 2007," were reported, indicating 347...

xerostomia, nausea, leukocytosis, fine tremor, Hyperreflexia, Deep tendon, Nephrotoxicity, Polyuria, Potential sign of toxicity, Increased thirst, Potential sign...

that will be targeted are the liver (hepatotoxicity), the kidneys (nephrotoxicity) and the lungs (pneumotoxicity). MCT falls into Category 3 toxicity...

significantly decreased kidney function;because contrast media can be nephrotoxic and worsen kidney function Antegrade pyelography is the procedure used...

shown that geniposide is safe at a dosage of 24.3 mg/kg or less. Acute nephrotoxicity was observed after an oral administration of geniposide (dose of 1.2...

failure or chronic kidney disease, given the potential hepatotoxicity and nephrotoxicity of some medications. Nodulectomy: surgical removal of cutaneous nodules...

but due to its strong association with severe side effects such as nephrotoxicity, its use is now often replaced with azoles and echinocandins. The use...

that this species hyperaccumulates silver. There are also reports about nephrotoxic effects similar to A. smithiana. Liddell, Henry George and Robert Scott...

with observed febrile neutropenia, neurotoxicity, ototoxicity, and nephrotoxicity. Remedial treatments to deal with chemotherapy-induced toxicities is...

January 2023. Plessis, Du (2006-03-08). Pathological investigation of the nephrotoxic effects of the shrub Nolletia gariepina (DC) Mattf. in cattle (Dissertation...

kidneys require less immunosuppression and less immunosuppression reduces nephrotoxicity and other negative side effects from post-transplant anti-rejection...

2020). "The selective c-Met inhibitor capmatinib offsets cisplatin-nephrotoxicity and doxorubicin-cardiotoxicity and improves their anticancer efficacies"...

pulmonary fibrosis, type 1 diabetes, autoimmune myasthenia gravis, nephrotoxic nephritis, acute cardiac allograft rejection, allergic contact dermatitis...

autotransfusion, and may actually become concentrated to the point of being nephrotoxic.[citation needed] When Avitene, Hemopad, Instat, or collagen type products...

molecular weight HES has been linked to coagulopathy, pruritus, as well as nephrotoxicity, acute renal failure and mortality. On the other hand, low molecular...

aristolochic acids (AAs). AAs are responsible for renal damage due to their nephrotoxic effects. When taken internally, AAs can be carcinogenic -  rhizomes used...

or kidney failure due to light chain myeloma cast nephropathy or the nephrotoxic effects of free light chains on renal tubular cells. Patients are treated...

Kondoh, M; Yoshioka, Y; Tsutsumi, Y; Yagi, K (2013). "Acute and chronic nephrotoxicity of platinum nanoparticles in mice". Nanoscale Research Letters. 8 (1):...

cyclosporine, and both AM1 and AM19 have been linked to nephropathy (nephrotoxicity). There should be little competitive inhibition of the parent drug by...

due to the fact that while studies have shown that it does act as a nephrotoxic and hepatotoxic agent, it is less toxic than other mycotoxins such as...

platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity". Life Sciences. 68 (10): 1181–90. doi:10.1016/s0024-3205(00)01028-6...

that some patients who take PTX experience adverse reactions, such as nephrotoxicity and neurotoxicity. SynCore Bio's EndoTAG-1 is a cationic liposome formulation...

monitoring of renal function, particularly in people taking potentially nephrotoxic medications such as lithium. The comorbidities involved in 17q12 microdeletion...

Satraplatin is similar in toxicity profile to carboplatin, with no nephrotoxicity, neurotoxicity, or ototoxicity observed. Moreover, it is much better...

0.5 to 0.75 mg/kg. Furthermore, amphotericin B deoxycholate is more nephrotoxic than liposomal amphotericin B; due to the expense of liposomal amphotericin...

association between pesticides and regional MeN epidemics, but a role of nephrotoxic agrochemicals nevertheless should not be conclusively discarded. Exposure...

also produced rare cases of anaphylaxis. Use of polymyxins may cause nephrotoxicity and neuropathy; damage to the kidney via systemic use of drugs or toxins...

Nephrotoxins and cardiotoxins are present but only inflict secondary nephrotoxicity and secondary cardiotoxicity. Standard first aid treatment for any bite...

01218. PMID 15226375. S2CID 931111. Zimmerman SE, Yong LC (May 1995). "Nephrotoxicity of notexin in experimental mice". Experimental and Toxicologic Pathology...

Viral Load in 90% of Treatment-Experienced Patients Tenofovir causing nephrotoxicity in persons with HIV Raltegravir producing virus suppression in Treatment-Naive...

monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity". J. Pharmacol. Exp. Ther. 304 (1): 185–91. doi:10.1124/jpet.102.042911...

and Stein JH. (1977). Effect of prostaglandin E administration in a nephrotoxic and a vasoconstrictor model of acute renal failure. Kidney International...

p-aminohippurate transport in kidney cortical slices in terms of its nephrotoxic action". Toxicology Letters. 15 (1): 49–56. doi:10.1016/0378-4274(83)90168-6...

and vomiting, the most severe toxicity observed. Some hepatotoxic and nephrotoxic effects were observed but were reversible. The phase I clinical trial...

Elizabeth; Pritchard, Jon (April 1991). "Partial reversibility of cisplatin nephrotoxicity in children". The Journal of Pediatrics. 118 (4): 531–534. doi:10...

highly interesting new compounds with promising properties, e.g., without nephrotoxic side effects. His structural investigations are significant contributions...

(NK cells) – NCI – New Drug Application – nebulized – Nef – neoplasm – nephrotoxic – neuralgia – neurological complications of AIDS – neuropathy – neutralization...