80144
231470
ENSG00000138759
ENSMUSG00000034687
Q86XX4
Q80T14
NM_001166133NM_020875NM_025074NM_032863NM_206841
NM_175473
NP_001159605NP_079350
NP_780682
Extracellular matrix protein FRAS1 is a protein that in humans is encoded by the FRAS1 (Fraser syndrome 1) gene.[5][6] This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development.
A single nucleotide switch (polymorphism) in FRAS1 promoter region is associated with metastatic Prostate cancer. The promoter region is directly related to the NFkB pathway and has been shown to be associated with lethal prostate cancer. [7]
Fras1 related extracellular matrix (FREM1[8]) directly relates to congenital diaphragmatic hernia in developing fetuses. Decreased expression of FREM1 may be linked with disruptions in the growth of diaphragm cells. Both FRAS1 and FREM1 are among the proteins that are primarily interacting during embryonic development. It is shown that a decrease in these two proteins lead to an increase of congenital diaphragmatic hernia in both humans and mice.[9]
Mutations in this gene have been observed to cause fraser syndrome.[10]
This biochemistry article is a stub. You can help Wikipedia by expanding it.
James Bradley Föddmars 1693Sherborne, StorbritannienDöd13 juli 1762[1] eller 13 mars 1762[2]ChalfordMedborgare iKungariket StorbritannienUtbildad vidBalliol CollegeOxfords universitet[3] SysselsättningAstronom[4], universitetslärareBefattningAstronomer Royal (1742–1762)[5]ArbetsgivareOxfords universitetUtmärkelserCopleymedaljen (1748)[6]Fellow of the Royal SocietyRedigera Wikidata James Bradley, född den 3 mars 1692 i Sherborne, Gloucestershire, död den 13 j…
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