1158/0008-5472.CAN-07-5989. PMID 18413721. Aggresomes: A Cellular Response to Misfolded Proteins Aggresomes protect cells by enhancing the degradation...

M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian MM (February 2004). "Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective". The Journal...

bodies in neurodegenerative diseases are aggregates of misfolded proteins (aggresomes) and are hallmarks of many of these diseases, including Lewy bodies in...

overworked. In mammalian cells, these protein aggregates are termed "aggresomes" and they are formed when the cell is diseased. This is because aggregates...

S (2007). "Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment". Hum. Mol. Genet. 16 (7): 753–62...

ATPase activity helicase activity hydrolase activity Cellular component aggresome nucleus nucleoplasm cytosol site of DNA damage chromosome Biological process...

doi:10.1016/0042-6822(80)90105-1. PMID 18631647. Wileman T (May 2006). "Aggresomes and autophagy generate sites for virus replication". Science. 312 (5775):...

endosome PML body late endosome P-body phagophore assembly site nucleoplasm aggresome autophagosome amphisome endoplasmic reticulum inclusion body lysosome...

neuron projection cytoskeleton presynaptic membrane mitochondrion cytosol aggresome synaptic vesicle trans-Golgi network membrane postsynaptic early endosome...

PMID 1527066. Johnston JA, Ward CL, Kopito RR (December 1998). "Aggresomes: a cellular response to misfolded proteins". The Journal of Cell Biology...

substrates could be sent to specific areas like aggresomes for additional processing. The aggresomes are stress-induced juxta-nuclear inclusion bodies...

region cytoskeleton nucleus kinetochore axon cytoplasm cytoplasm cytosol aggresome perinuclear region of cytoplasm nuclear envelope nucleoplasm spindle nuclear...

Tabrizi, Sarah J. (18 November 2005). "Disease-related Prion Protein Forms Aggresomes in Neuronal Cells Leading to Caspase Activation and Apoptosis". Journal...

component cytosol ESC/E(Z) complex intracellular anatomical structure aggresome perinuclear region of cytoplasm peroxisome cytoplasm Biological process...

"The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation". Journal of Cell Science. 115 (Pt 14): 2907–2918. doi:10.1242/jcs...

phosphatase inhibitor activity nucleosome binding Cellular component aggresome nucleus nucleoplasm cytosol Biological process cell surface receptor signaling...

some are not. Note the following four examples: HDAC6 is associated with aggresomes. Misfolded protein aggregates are tagged by ubiquitination and removed...

nucleus multivesicular body cell projection microtubule associated complex aggresome dynein complex histone deacetylase complex perikaryon axon inclusion body...

function proteasome binding protein binding Cellular component cytoplasm aggresome nucleus fibrillar center cytosol Biological process positive regulation...

membrane focal adhesion plasma membrane sarcoplasmic reticulum nucleoplasm aggresome cell junction myofibril Z discdkac meiotic nuclear membrane microtubule...

Kagan, Jonathan C.; Schmidt, Florian I. (2020-09-18). "HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation". Science....

II-specific Cellular component nucleus nucleoplasm nucleolus cytosol aggresome Biological process cardiac septum development heart valve development...

3'-5'-exoribonuclease activity RNA binding Cellular component membrane aggresome nucleolus nucleus nucleoplasm Biological process RNA processing regulation...

Inclusions containing α-synuclein and synphilin-1 share features with aggresomes, which may act to sequester misfolded proteins and limit cellular toxicity...

activity Cellular component cytoplasm PML body nucleolus nucleus nucleoplasm aggresome nuclear body Biological process cell surface receptor signaling pathway...

perinuclear region of cytoplasm nucleus Lewy body SCF ubiquitin ligase complex aggresome endoplasmic reticulum Golgi apparatus Parkin-FBXW7-Cul1 ubiquitin ligase...

nucleus kinetochore centrosome rough endoplasmic reticulum dendritic shaft aggresome cell surface membrane-bounded organelle endoplasmic reticulum membrane...

novo purine biosynthesis. However, nocodazole also blocks formation of aggresomes, complicating interpretation of these observations. Partial inhibition...

protein C-terminus binding protein binding Cellular component cytoplasm aggresome Cajal body nucleus nucleoplasm actin cytoskeleton Biological process response...

substrates) were reported to form different kinds of inclusion bodies (e.g. aggresomes, amyloids), yet it remained obscure if those observations combine into...

binding Cellular component cytoplasm cytosol endosome membrane nucleoplasm aggresome Biological process phosphorylation positive regulation of interferon-alpha...

autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS). Autophagy, 7: 29–31. Fujita K, Xiao Q...

efficacy of mammalian cells may be limited by epigenetic gene silencing and aggresome formation (recombinant protein aggregation). For mammalian cells, synthesised...

binding Cellular component cytoplasm polysome membrane plasma membrane aggresome membrane raft extracellular exosome nucleus polysomal ribosome extracellular...

binding Cellular component cytoplasm membrane plasma membrane nucleoplasm aggresome autophagosome endoplasmic reticulum perinuclear region of cytoplasm proteasome...

anatomical structure immunological synapse microtubule organizing center aggresome Biological process intracellular signal transduction regulation of transcription...

reticulum endoplasmic reticulum quality control compartment Golgi membrane aggresome Biological process N-glycan processing positive regulation of retrograde...

membrane membrane intracellular membrane-bounded organelle plasma membrane aggresome ciliary membrane clathrin-coated pit AP-2 adaptor complex clathrin-coated...

serine/threonine kinase activity Cellular component cytoplasm nucleus cytosol aggresome Biological process protein phosphorylation cell cycle negative regulation...

Sooyoung; Kim, Bonglee; Rhim, Hyewhon (2022). "Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease"...

clathrin-coated vesicle cytoplasm cytoplasmic vesicle nucleus cytosol nucleoplasm aggresome lateral plasma membrane nuclear body Biological process non-canonical...

extracellular exosome cytoskeleton extracellular region plasma membrane aggresome secretory granule lumen Biological process cell differentiation regulation...

component transcription repressor complex nucleus nucleoplasm cytosol aggresome cytoplasm Biological process positive regulation of brown fat cell differentiation...

center cytoskeleton nucleus cytoplasm mitochondrion endoplasmic reticulum aggresome nuclear speck vesicle extracellular exosome COP9 signalosome protein-containing...

reticulum stress response (ER stress) Mitochondrial unfolded protein response Aggresome PERK inhibitors Hetz C, Papa FR (January 2018). "The Unfolded Protein...

follicular lymphoma in apparently healthy individuals, and of dendritic cell aggresome-like induced structures (DALIS) in dendritic cells, thought to play an...

suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes". Oncogene. 26 (33): 4797–805. doi:10.1038/sj.onc.1210281. PMID 17311003...

accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes". J. Biochem. 131 (4): 593–603. doi:10.1093/oxfordjournals.jbchem.a003139...

Kagan, Jonathan C.; Schmidt, Florian I. (2020-09-18). "HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation". Science....

endoplasmic reticulum (ER) associated degradation (ERAD). He coined the term aggresome to describe intracellular inclusions that collect aggregated proteins...

exonuclease activity hydrolase activity Cellular component membrane nucleoplasm aggresome nucleotide-excision repair complex nucleus delta DNA polymerase complex...

polymerase II-specific Cellular component nucleus nucleoplasm cytosol aggresome Biological process regulation of transcription, DNA-templated transcription...

center cytoskeleton nucleus cytoplasm mitochondrion endoplasmic reticulum aggresome nuclear speck vesicle extracellular exosome COP9 signalosome protein-containing...

(November 2010). "Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis". Cancer Research. 70 (22): 9265–9276...

ubiquitin-dependent protein catabolic process protein hexamerization aggresome assembly flavin adenine dinucleotide catabolic process proteasome-mediated...

Alzheimer's Disease Brain Induce Intracellular Accumulation of Tau in Aggresomes". J Biol Chem. 287 (24): 20522–33. doi:10.1074/jbc.M111.323279. PMC 3370237...

RS, Ito A, Yoshida M, Yao TP (September 2013). "Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains". Molecular...

activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm aggresome Biological process embryonic skeletal system morphogenesis multicellular...

cis-regulatory region sequence-specific DNA binding Cellular component aggresome nucleoplasm nucleus nuclear body Biological process Notch signaling pathway...

2004). "A novel action of histone deacetylase inhibitors in a protein aggresome disease model". primary. Current Biology. 14 (6): 488–92. Bibcode:2004CBio...

parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy...

rare disorder causing progressive muscular weakness characterized by aggresome-like inclusions in the myofibrils. The effects of the disorder can be...

Szebenyi G, Wigley WC, Hall B, et al. (2007). "Hook2 contributes to aggresome formation". BMC Cell Biol. 8 19. doi:10.1186/1471-2121-8-19. PMC 1896156...