CABIN1

CABIN1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCABIN1, CAIN, PPP3IN, KB-318B8.7, calcineurin binding protein 1
External IDsOMIM: 604251; MGI: 1298375; HomoloGene: 49307; GeneCards: CABIN1; OMA:CABIN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

23523

104248

Ensembl

ENSG00000099991
ENSG00000281670

ENSMUSG00000020196

UniProt

Q9Y6J0

n/a

RefSeq (mRNA)

NM_001199281
NM_001201429
NM_012295

NM_172549

RefSeq (protein)

NP_001186210
NP_001188358
NP_036427

n/a

Location (UCSC)Chr 22: 24.01 – 24.18 MbChr 10: 75.48 – 75.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the CABIN1 gene.[5][6][7]

Function

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.[7]

Interactions

CABIN1 has been shown to interact with:

References

  1. ^ a b c ENSG00000281670 GRCh38: Ensembl release 89: ENSG00000099991, ENSG00000281670 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020196 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO (Jun 1998). "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes". Immunity. 8 (6): 703–11. doi:10.1016/S1074-7613(00)80575-0. PMID 9655484.
  6. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  7. ^ a b "Entrez Gene: CABIN1 calcineurin binding protein 1".
  8. ^ Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH (Nov 2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". The Journal of Biological Chemistry. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
  9. ^ Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature. 422 (6933): 730–4. Bibcode:2003Natur.422..730H. doi:10.1038/nature01555. PMID 12700764. S2CID 4430658.
  10. ^ a b Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.
  11. ^ a b Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.

Further reading


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