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PICK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GZV
Identifiers
Aliases	PICK1, PICK, PRKCABP, protein interacting with PRKCA 1
External IDs	OMIM: 605926; MGI: 894645; HomoloGene: 7470; GeneCards: PICK1; OMA:PICK1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,075,701 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,133,684 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right hemisphere of cerebellum; ; right uterine tube; ; left ovary; ; right frontal lobe; ; left testis; ; right testis; ; gastric mucosa; ; right ovary; ; body of pancreas;
	Top expressed in
	neural layer of retina; ; spermatid; ; muscle of thigh; ; spermatocyte; ; superior frontal gyrus; ; right kidney; ; lip; ; crypt of lieberkuhn of small intestine; ; extensor digitorum longus muscle; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; Arp2/3 complex binding; metal ion binding; actin filament binding; protein C-terminus binding; protein binding; identical protein binding; enzyme binding; actin binding; signaling receptor binding; G protein-coupled receptor binding; protein kinase C binding; phospholipid binding;
Cellular component	cytoplasm; endocytic vesicle membrane; postsynaptic membrane; Golgi apparatus; postsynaptic density; membrane; plasma membrane; synapse; cell junction; perinuclear region of cytoplasm; neuron projection; cytoskeleton; presynaptic membrane; mitochondrion; cytosol; aggresome; synaptic vesicle; trans-Golgi network membrane; postsynaptic early endosome;
Biological process	cellular response to glucose starvation; glial cell development; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; positive regulation of receptor internalization; neuronal ion channel clustering; regulation of Arp2/3 complex-mediated actin nucleation; monoamine transport; receptor clustering; DNA methylation involved in gamete generation; negative regulation of Arp2/3 complex-mediated actin nucleation; dendritic spine organization; dendritic spine maintenance; protein phosphorylation; protein kinase C-activating G protein-coupled receptor signaling pathway; long-term depression; cellular response to decreased oxygen levels; DNA methylation involved in embryo development; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
	9463
	18693
	ENSG00000100151
	ENSMUSG00000068206
	Q9NRD5
	Q62083
	NM_001039583; NM_001039584; NM_012407
	NM_001045558; NM_008837
NP_001034672; NP_001034673; NP_036539; NP_001034672.1; NP_001034673.1;
	NP_036539.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.^[5]^[6]

Function

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.^[7]

Interactions

PICK1 has been shown to interact with:

ACCN2,^[8]^[9]
BNC1,^[9]
Dopamine transporter,^[10]
GRIA2,^[11]
GRIA3,^[11]
GRIA4,^[11]
GRIK1,^[12]
GRIK2,^[12]
GRIK3,^[11]
HER2/neu,^[13]
Metabotropic glutamate receptor 3,^[11] and
Metabotropic glutamate receptor 7.^[14]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100151 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068206 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dev KK, Nishimune A, Henley JM, Nakanishi S (July 1999). "The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits". Neuropharmacology. 38 (5): 635–44. doi:10.1016/S0028-3908(98)00230-5. PMID 10340301. S2CID 20472140.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ "Entrez Gene: PICK1 protein interacting with PRKCA 1".
^ Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (February 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. Bibcode:2003PNAS..100.2029L. doi:10.1073/pnas.252782799. PMC 149953. PMID 12578970.
^ ^a ^b Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (February 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773.
^ Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG (April 2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron. 30 (1): 121–34. doi:10.1016/s0896-6273(01)00267-7. PMID 11343649.
^ ^a ^b ^c ^d ^e Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs" (PDF). J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
^ ^a ^b Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron. 37 (4): 625–38. doi:10.1016/s0896-6273(02)01191-1. PMC 3314502. PMID 12597860.
^ Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP (May 2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603.
^ Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (October 2000). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. doi:10.1523/JNEUROSCI.20-19-07252.2000. PMC 6772771. PMID 11007882.

External links

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100151 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068206 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10340301-5] Dev KK, Nishimune A, Henley JM, Nakanishi S (July 1999). "The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits". Neuropharmacology. 38 (5): 635–44. doi:10.1016/S0028-3908(98)00230-5. PMID 10340301. S2CID 20472140.

[pmid10591208-6] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[entrez-7] "Entrez Gene: PICK1 protein interacting with PRKCA 1".

[pmid12578970-8] Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (February 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. Bibcode:2003PNAS..100.2029L. doi:10.1073/pnas.252782799. PMC 149953. PMID 12578970.

[pmid11802773-9] Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (February 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773.

[pmid11343649-10] Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG (April 2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron. 30 (1): 121–34. doi:10.1016/s0896-6273(01)00267-7. PMID 11343649.

[pmid11891216-11] Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs" (PDF). J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.

[pmid12597860-12] Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron. 37 (4): 625–38. doi:10.1016/s0896-6273(02)01191-1. PMC 3314502. PMID 12597860.

[pmid11278603-13] Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP (May 2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603.

[pmid11007882-14] Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (October 2000). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. doi:10.1523/JNEUROSCI.20-19-07252.2000. PMC 6772771. PMID 11007882.

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PICK1

Function

Interactions

References

Further reading

External links