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SRL
Identifiers
Aliases	SRL, entrez:6345, sarcalumenin, SAR
External IDs	OMIM: 604992; MGI: 2146620; HomoloGene: 45500; GeneCards: SRL; OMA:SRL - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	4,242,080 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	4,359,680 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; myocardium of left ventricle; ; Skeletal muscle tissue of rectus abdominis; ; apex of heart; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; cardiac muscle tissue of right atrium; ; right auricle; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	interventricular septum; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; temporal muscle; ; vastus lateralis muscle; ; extraocular muscle; ; muscle of thigh; ; medial head of gastrocnemius muscle; ; ankle; ; digastric muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTP binding;
Cellular component	sarcoplasmic reticulum; sarcoplasmic reticulum lumen;
Biological process	store-operated calcium entry; response to muscle activity involved in regulation of muscle adaptation;
	Sources:Amigo / QuickGO
Orthologs
	6345
	106393
	ENSG00000185739
	ENSMUSG00000022519
	Q86TD4
	Q7TQ48
	NM_001098814; NM_001323667; NM_001323668
	NM_175347; NM_001347162; NM_001361474
	NP_001092284; NP_001310596; NP_001310597
	NP_001334091; NP_780556; NP_001348403
	Wikidata
View/Edit Human	View/Edit Mouse

Sarcalumenin is a protein that in humans is encoded by the SRL gene.^[5]^[6]

Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle.^[7] Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins.^[8] Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity.^[7] Sarcalumenin is a calcium-binding glycoprotein composed of 473 acidic amino acids with a molecular weight of 160 KDa. Together along with other luminal calcium buffer proteins, sarcalumenin plays an important role in regulation of calcium uptake and release during excitation-contraction coupling (ECC) in muscle fibers.