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ANXA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AII, 1AXN
Identifiers
Aliases	ANXA3, ANX3, annexin A3
External IDs	OMIM: 106490; MGI: 1201378; HomoloGene: 68445; GeneCards: ANXA3; OMA:ANXA3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	78,610,451 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	96,993,825 bp
RNA expression pattern
	Top expressed in
	right lung; ; germinal epithelium; ; bone marrow; ; upper lobe of left lung; ; bone marrow cells; ; minor salivary glands; ; left lobe of thyroid gland; ; trabecular bone; ; right lobe of thyroid gland; ; body of stomach;
	Top expressed in
	right lung lobe; ; mucous cell of stomach; ; pyloric antrum; ; endothelial cell of lymphatic vessel; ; left lung; ; granulocyte; ; left lung lobe; ; decidua; ; epithelium of stomach; ; gastrula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase inhibitor activity; calcium ion binding; phospholipase A2 inhibitor activity; calcium-dependent protein binding; calcium-dependent phospholipid binding;
Cellular component	cytoplasm; phagocytic vesicle membrane; membrane; plasma membrane; axon; soma; dendrite; specific granule; extracellular exosome; cytosol;
Biological process	negative regulation of catalytic activity; positive regulation of DNA metabolic process; neutrophil degranulation; positive regulation of DNA-binding transcription factor activity; response to glucocorticoid; positive regulation of angiogenesis; positive regulation of endothelial cell migration; defense response to bacterium; animal organ regeneration; phagocytosis; response to growth factor; hippocampus development; homophilic cell adhesion via plasma membrane adhesion molecules; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	306
	11745
	ENSG00000138772
	ENSMUSG00000029484
	P12429
	O35639
	NM_005139
	NM_013470
	NP_005130
	NP_038498
	Wikidata
View/Edit Human	View/Edit Mouse

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.^[5]^[6]

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.^[7]

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138772 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029484 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tait JF, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM (Aug 1991). "Chromosomal localization of the human annexin III (ANX3) gene". Genomics. 10 (2): 441–8. doi:10.1016/0888-7543(91)90330-H. PMID 1830024.
^ ^a ^b "Entrez Gene: ANXA3 annexin A3".
^ Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human placenta derived from assisted reproductive technology". Proteomics. 8 (20): 4344–56. doi:10.1002/pmic.200800294. PMID 18792929. S2CID 206362532.

External links

Human ANXA3 genome location and ANXA3 gene details page in the UCSC Genome Browser.

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