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CAPN5
Identifiers
Aliases	CAPN5, ADNIV, HTRA3, VRNI, nCL-3, calpain 5
External IDs	OMIM: 602537; MGI: 1100859; HomoloGene: 31212; GeneCards: CAPN5; OMA:CAPN5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	77,126,155 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,178,274 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; gallbladder; ; right lobe of liver; ; stromal cell of endometrium; ; mucosa of esophagus; ; duodenum; ; body of stomach; ; mucosa of ileum; ; palpebral conjunctiva;
	Top expressed in
	transitional epithelium of urinary bladder; ; lumbar spinal ganglion; ; pyloric antrum; ; epithelium of stomach; ; conjunctival fornix; ; mucous cell of stomach; ; perirhinal cortex; ; fetal liver hematopoietic progenitor cell; ; corneal stroma; ; entorhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; hydrolase activity; calcium-dependent cysteine-type endopeptidase activity;
Cellular component	cell surface; extracellular exosome; intracellular anatomical structure; focal adhesion; cytoplasm;
Biological process	signal transduction; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	726
	12337
	ENSG00000149260
	ENSMUSG00000035547
	O15484
	O08688
	NM_004055
	NM_001301250; NM_007602
	NP_004046
	NP_001288179; NP_031628
	Wikidata
View/Edit Human	View/Edit Mouse

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.^[5]^[6]^[7]

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149260 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035547 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matena K, Boehm T, Dear N (Apr 1998). "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily". Genomics. 48 (1): 117–20. doi:10.1006/geno.1997.5133. PMID 9503024.
^ Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M (Dec 1997). "Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene". Biochem Biophys Res Commun. 239 (3): 845–50. doi:10.1006/bbrc.1997.7571. PMID 9367857.
^ ^a ^b "Entrez Gene: CAPN5 calpain 5".

External links

The MEROPS online database for peptidases and their inhibitors: C02.011 Archived 2005-03-08 at the Wayback Machine
Human CAPN5 genome location and CAPN5 gene details page in the UCSC Genome Browser.
Human HTRA3 genome location and HTRA3 gene details page in the UCSC Genome Browser.