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CTSF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M6D
Identifiers
Aliases	CTSF, CATSF, CLN13, cathepsin F
External IDs	OMIM: 603539; MGI: 1861434; HomoloGene: 31194; GeneCards: CTSF; OMA:CTSF - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,568,879 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,910,946 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; left testis; ; right testis; ; right coronary artery; ; left ovary; ; right frontal lobe; ; right ovary; ; tibial nerve; ; gastric mucosa; ; ascending aorta;
	Top expressed in
	neural layer of retina; ; adrenal gland; ; right kidney; ; choroid plexus of fourth ventricle; ; lip; ; cerebellar cortex; ; primary visual cortex; ; epithelium of lens; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; hydrolase activity; cysteine-type endopeptidase activity;
Cellular component	extracellular vesicle; lysosome; lysosomal lumen; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	proteolysis involved in cellular protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	8722
	56464
	ENSG00000174080
	ENSMUSG00000083282
	Q9UBX1
	Q9R013
	NM_003793
	NM_019861
	NP_003784
	NP_063914
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin F is a protein that in humans is encoded by the CTSF gene.^[5]^[6]^[7]

Cysteine cathepsins are a family of cysteine proteases that represent a major component of the lysosomal proteolytic system. In general, cathepsins contain a signal peptide, followed by a propeptide and then a catalytically active mature region. The very long (251-amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of Cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids that contains a 19-residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.^[7]

In non-human species

Immunodiagnosis of Opisthorchis viverrini

Opisthorchis viverrini, a parasite, is typically detected by stool examination, specifically by counting eggs. However, this non-invasive, "gold standard" method can be unreliable in light infection and labor-intensive. An ELISA assay that detects the presence of the parasite's cathepsin F protein may be used as an alternative way to test for the parasite's presence.^[8]

Discovery in Yesso scallop (Mizuhopecten yessoensis)

The Yesso scallop (Mizuhopecten yessoensis), was found in 2018 to express Cathepsin F in response to bacterial infection. The Yesso scallop has been suffering from high mortality due to bacterial diseases. Understanding the workings of its innate immune system, in various embryonic developmental stages, may help the associated aquaculture industry.^[9]