Calpain-2 catalytic subunit

CAPN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAPN2, CANP2, CANPL2, CANPml, mCANP, calpain 2
External IDsOMIM: 114230; MGI: 88264; HomoloGene: 1326; GeneCards: CAPN2; OMA:CAPN2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146068
NM_001748

NM_009794

RefSeq (protein)

NP_001139540
NP_001739

NP_033924

Location (UCSC)Chr 1: 223.7 – 223.78 MbChr 1: 182.29 – 182.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene.[5][6]

Function

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported.[7]

Interactions

CAPN2 has been shown to interact with Bcl-2.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162909Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026509Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Imajoh S, Aoki K, Ohno S, Emori Y, Kawasaki H, Sugihara H, Suzuki K (1988). "Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease". Biochemistry. 27 (21): 8122–8. doi:10.1021/bi00421a022. PMID 2852952.
  6. ^ Hata A, Ohno S, Akita Y, Suzuki K (May 1989). "Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease". J. Biol. Chem. 264 (11): 6404–11. doi:10.1016/S0021-9258(18)83364-6. PMID 2539381.
  7. ^ "Entrez Gene: CAPN2 calpain 2, (m/II) large subunit".
  8. ^ Gil-Parrado S, Fernández-Montalván A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H, Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W (Jul 2002). "Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members". J. Biol. Chem. 277 (30): 27217–26. doi:10.1074/jbc.M202945200. PMID 12000759.

Further reading