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KCNIP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E6W
Identifiers
Aliases	KCNIP3, CSEN, DREAM, KCHIP3, potassium voltage-gated channel interacting protein 3
External IDs	OMIM: 604662; MGI: 1929258; HomoloGene: 8382; GeneCards: KCNIP3; OMA:KCNIP3 - orthologs
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,364,014 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; left lobe of thyroid gland; ; amygdala; ; right lobe of thyroid gland; ; nucleus accumbens; ; caudate nucleus; ; hypothalamus; ; putamen; ; hippocampus proper;
	Top expressed in
	lumbar spinal ganglion; ; primary visual cortex; ; superior frontal gyrus; ; piriform cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; medial dorsal nucleus; ; subiculum; ; prefrontal cortex; ; medial geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; calcium ion binding; sequence-specific DNA binding; potassium channel activity; transcription corepressor activity; voltage-gated ion channel activity; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; potassium channel regulator activity; transmembrane transporter binding;
Cellular component	cytoplasm; axon terminus; cytosol; Golgi apparatus; membrane; voltage-gated potassium channel complex; axon; dendrite; protein-DNA complex; endoplasmic reticulum; nucleus; plasma membrane;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; regulation of ion transmembrane transport; negative regulation of transcription by RNA polymerase II; ion transport; transcription, DNA-templated; potassium ion transport; potassium ion transmembrane transport; protein localization to plasma membrane; intracellular protein transport; regulation of potassium ion transmembrane transport; signal transduction; apoptotic process; negative regulation of nucleic acid-templated transcription; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	30818
	56461
	n/a
	ENSMUSG00000079056
	Q9Y2W7
	Q9QXT8; P0C092
	NM_001034914; NM_013434
	NM_001111331; NM_001291005; NM_019789
	NP_001030086; NP_038462
	NP_001104801; NP_001277934; NP_062763
	Wikidata
View/Edit Human	View/Edit Mouse

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.^[4]^[5]^[6]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.^[7]^[8] Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. In addition, the protein has been shown to transcriptionally repress A20 (TNFAIP3) expression and thus modulate the anti-inflammatory signaling.^[9] Alternatively spliced transcript variants encoding different isoforms have been described.^[6]

Interactions

Calsenilin has been shown to interact with PSEN1^[4]^[10] and PSEN2.^[4]^[11]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079056 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752. S2CID 10799492.
^ Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. Bibcode:1999Natur.398...80C. doi:10.1038/18044. PMID 10078534. S2CID 204991618.
^ ^a ^b "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin".
^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. S2CID 24156457.
^ Tiruppathi C, Soni D, Wang DM, et al. (March 2014). "The transcription factor DREAM represses A20 and mediates inflammation". Nat Immunol. 15 (3): 239–247. doi:10.1038/ni.2823. PMC 4005385. PMID 24487321.
^ Kashiwa A, Yoshida H, Lee S, Paladino T, Liu Y, Chen Q, Dargusch R, Schubert D, Kimura H (July 2000). "Isolation and characterization of novel presenilin binding protein". J. Neurochem. 75 (1): 109–16. doi:10.1046/j.1471-4159.2000.0750109.x. PMID 10854253. S2CID 24838995.
^ Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W (June 2001). "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2". J. Biol. Chem. 276 (22): 19197–204. doi:10.1074/jbc.M008597200. PMID 11278424.

External links

KCNIP3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
NCS proteins

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000079056 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9771752-4] Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752. S2CID 10799492.

[pmid10078534-5] Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. Bibcode:1999Natur.398...80C. doi:10.1038/18044. PMID 10078534. S2CID 204991618.

[entrez-6] "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin".

[pmid17311005-7] Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

[pmid15046879-8] Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. S2CID 24156457.

[PMC4005385-9] Tiruppathi C, Soni D, Wang DM, et al. (March 2014). "The transcription factor DREAM represses A20 and mediates inflammation". Nat Immunol. 15 (3): 239–247. doi:10.1038/ni.2823. PMC 4005385. PMID 24487321.

[pmid10854253-10] Kashiwa A, Yoshida H, Lee S, Paladino T, Liu Y, Chen Q, Dargusch R, Schubert D, Kimura H (July 2000). "Isolation and characterization of novel presenilin binding protein". J. Neurochem. 75 (1): 109–16. doi:10.1046/j.1471-4159.2000.0750109.x. PMID 10854253. S2CID 24838995.

[pmid11278424-11] Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W (June 2001). "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2". J. Biol. Chem. 276 (22): 19197–204. doi:10.1074/jbc.M008597200. PMID 11278424.

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Calsenilin

Function

Interactions

See also

References

Further reading

External links