KCNU1
Protein-coding gene in the species Homo sapiens
Potassium channel, subfamily U, member 1 , also known as KCNU1 , is a gene encoding the KCa 5.1 protein .[ 4]
Although this channel is structurally related to the calcium-activated potassium channels , it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.[ 5] [ 6] [ 7]
References
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031576 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes" . J. Biol. Chem . 273 (6): 3509–16. doi :10.1074/jbc.273.6.3509 PMID 9452476 . ^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol Rev . 57 (4): 463–72. doi :10.1124/pr.57.4.9 . PMID 16382103 . S2CID 8290401 . ^ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K+ channels: properties of unitary currents" . J. Gen. Physiol . 128 (3): 301–15. doi :10.1085/jgp.200609551 . PMC 2151565 PMID 16940554 . ^ Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K+ channels: voltage and pH dependence of macroscopic currents" . J. Gen. Physiol . 128 (3): 317–36. doi :10.1085/jgp.200609552 . PMC 2151566 PMID 16940555 .
Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).
External links
Overview of all the structural information available in the PDB for UniProt : A8MYU2 PDBe-KB .
Further reading
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Schreiber M, Wei A, Yuan A, et al. (1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes" . J. Biol. Chem . 273 (6): 3509–16. doi :10.1074/jbc.273.6.3509 PMID 9452476 . Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8" . Nature . 439 (7074): 331–5. Bibcode :2006Natur.439..331N . doi :10.1038/nature04406 PMID 16421571 . Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev . 57 (4): 463–72. doi :10.1124/pr.57.4.9 . PMID 16382103 . S2CID 8290401 .
Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).
