ITPR3
Protein-coding gene in the species Homo sapiens
Inositol 1,4,5-trisphosphate receptor, type 3 , also known as ITPR3 , is a protein which in humans is encoded by the ITPR3 gene .[ 5] protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel .[ 6]
Function
ITP3 channels serve an important role in the taste transduction pathway of sweet , bitter and umami tastes the gustatory system . ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential .[ 7]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000096433 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042644 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: inositol 1" .^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels . 2 (1): 9–22. PMID 8081734 . ^ Chaudhari N, Roper SD (August 2010). "The cell biology of taste" . J. Cell Biol . 190 (3): 285–96. doi :10.1083/jcb.201003144 . PMC 2922655 PMID 20696704 .
Further reading
Kline CF, Cunha SR, Lowe JS, et al. (2008). "Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor" . J. Cell. Biochem . 104 (4): 1244–53. doi :10.1002/jcb.21704 . PMC 2858327 PMID 18275062 . Oishi T, Iida A, Otsubo S, et al. (2008). "A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population" . J. Hum. Genet . 53 (2): 151–62. doi :10.1007/s10038-007-0233-3 PMID 18219441 . Hirose M, Stuyvers B, Dun W, et al. (2008). "Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells" . J. Mol. Cell. Cardiol . 45 (2): 176–84. doi :10.1016/j.yjmcc.2008.05.008 . PMC 2566512 PMID 18586264 . Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". Mod Rheumatol . 17 (2): 137–43. doi :10.1007/s10165-006-0555-6 . PMID 17437169 . S2CID 36516047 . Tang TS, Guo C, Wang H, et al. (2009). "Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model" . J. Neurosci . 29 (5): 1257–66. doi :10.1523/JNEUROSCI.4411-08.2009 . PMC 2768402 PMID 19193873 . Nagaleekar VK, Diehl SA, Juncadella I, et al. (2008). "IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program" . J. Immunol . 181 (12): 8315–22. doi :10.4049/jimmunol.181.12.8315 . PMC 2756541 PMID 19050248 . Bandyopadhyay BC, Swaim WD, Liu X, et al. (2005). "Apical localization of a functional TRPC3/TRPC6-Ca2+ -signaling complex in polarized epithelial cells. Role in apical Ca2+ influx" . J. Biol. Chem . 280 (13): 12908–16. doi :10.1074/jbc.M410013200 PMID 15623527 . Kasri NN, Holmes AM, Bultynck G, et al. (2004). "Regulation of InsP3 receptor activity by neuronal Ca2+ -binding proteins" . EMBO J . 23 (2): 312–21. doi :10.1038/sj.emboj.7600037 . PMC 1271747 PMID 14685260 . Hattori M, Suzuki AZ, Higo T, et al. (2004). "Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling" . J. Biol. Chem . 279 (12): 11967–75. doi :10.1074/jbc.M311456200 PMID 14707143 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Roach JC, Deutsch K, Li S, et al. (2006). "Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden" . Am. J. Hum. Genet . 79 (4): 614–27. doi :10.1086/507876 . PMC 1592562 PMID 16960798 . Tojyo Y, Morita T, Nezu A, Tanimura A (2008). "The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca2+ store" . J. Pharmacol. Sci . 107 (2): 138–50. doi :10.1254/jphs.08021FP PMID 18544901 . Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation". Exp. Cell Res . 295 (1): 102–18. doi :10.1016/j.yexcr.2003.12.025 . PMID 15051494 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Ogasawara H (2008). "The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection" . J. Neurosci . 28 (17): 4293–4. doi :10.1523/JNEUROSCI.0644-08.2008 PMC 6670947 PMID 18434505 . Qu HQ, Marchand L, Szymborski A, et al. (2008). "The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II". Genes Immun . 9 (3): 264–6. doi :10.1038/gene.2008.12 . PMID 18340361 . S2CID 8563179 . Wu Z, Bowen WD (2008). "Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells" . J. Biol. Chem . 283 (42): 28198–215. doi :10.1074/jbc.M802099200 PMC 2661391 PMID 18539593 . Martínez-Gámez A, Dent MA (2007). "Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve". NeuroReport . 18 (5): 447–50. doi :10.1097/WNR.0b013e32805868a6 . PMID 17496801 . S2CID 28136973 . Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA (2008). "IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site" . J. Biol. Chem . 283 (46): 31284–8. doi :10.1074/jbc.C800184200 PMID 18826956 . Sundivakkam PC, Kwiatek AM, Sharma TT, et al. (2009). "Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells" . Am. J. Physiol., Cell Physiol . 296 (3): C403–13. doi :10.1152/ajpcell.00470.2008 . PMC 2660268 PMID 19052258 .
External links
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