PROFILPELAJAR.COM

MYO1F
Identifiers
Aliases	MYO1F, myosin IF
External IDs	OMIM: 601480; MGI: 107711; HomoloGene: 56276; GeneCards: MYO1F; OMA:MYO1F - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	8,577,577 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	33,826,738 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; spleen; ; bone marrow cells; ; right lung; ; appendix; ; upper lobe of left lung; ; sural nerve; ; trabecular bone;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; blood; ; spleen; ; mesenteric lymph nodes; ; lumbar spinal ganglion; ; calvaria; ; thymus; ; subcutaneous adipose tissue; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; actin binding; cytoskeletal motor activity; ATP binding; calmodulin binding; microtubule motor activity; microtubule binding;
Cellular component	unconventional myosin complex; myosin complex;
Biological process	biological process; microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	4542
	17916
	ENSG00000142347
	ENSMUSG00000024300
	O00160
	P70248
	NM_012335; NM_001348355
	NM_053214
	NP_036467; NP_001335284
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-If is a protein that in humans is encoded by the MYO1F gene.^[5]^[6]^[7]

It is expressed mainly in the immune system and might be involved in cell adhesion and motility.^[8] It is a candidate gene for (among other things) nonsyndromic deafness.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142347 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024300 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID 9119401.
^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
^ "Entrez Gene: MYO1F myosin IF".
^ Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA (October 2006). "Modulation of cell adhesion and motility in the immune system by Myo1f". Science. 314 (5796): 136–9. Bibcode:2006Sci...314..136K. doi:10.1126/science.1131920. PMID 17023661. S2CID 12479761.
^ Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ (August 2001). "MYO1F as a candidate gene for nonsyndromic deafness, DFNB15". Arch. Otolaryngol. Head Neck Surg. 127 (8): 921–5. doi:10.1001/archotol.127.8.921. PMID 11493199.