ACTG2

ACTG2
Identifiers
AliasesACTG2, ACT, ACTA3, ACTE, ACTL3, ACTSG, VSCM, actin, gamma 2, smooth muscle, enteric, actin gamma 2, smooth muscle, VSCM1, MMIHS5
External IDsOMIM: 102545; MGI: 104589; HomoloGene: 123845; GeneCards: ACTG2; OMA:ACTG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

72

11468

Ensembl

ENSG00000163017

ENSMUSG00000059430

UniProt

P63267

P63268

RefSeq (mRNA)

NM_001615
NM_001199893

NM_009610

RefSeq (protein)

NP_001186822
NP_001606

NP_033740

Location (UCSC)Chr 2: 73.89 – 73.92 MbChr 6: 83.49 – 83.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Actin, gamma-enteric smooth muscle is a protein that in humans is encoded by the ACTG2 gene.[5][6][7]

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 2, encoded by this gene, is a smooth muscle actin found in enteric tissues.[7]

Interactions

ACTG2 has been shown to interact with Emerin.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163017 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059430 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miwa T, Manabe Y, Kurokawa K, Kamada S, Kanda N, Bruns G, Ueyama H, Kakunaga T (July 1991). "Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes". Mol Cell Biol. 11 (6): 3296–306. doi:10.1128/mcb.11.6.3296. PMC 360182. PMID 1710027.
  6. ^ Ueyama H (May 1991). "A HindIII DNA polymorphism in the human enteric type smooth muscle actin gene (ACTSG)". Nucleic Acids Res. 19 (2): 411. doi:10.1093/nar/19.2.411. PMC 333620. PMID 1673027.
  7. ^ a b "Entrez Gene: ACTG2 actin, gamma 2, smooth muscle, enteric".
  8. ^ Lattanzi G, Cenni Vittoria, Marmiroli Sandra, Capanni Cristina, Mattioli Elisabetta, Merlini Luciano, Squarzoni Stefano, Maraldi Nadir Mario (April 2003). "Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts". Biochem. Biophys. Res. Commun. 303 (3). United States: 764–70. doi:10.1016/S0006-291X(03)00415-7. ISSN 0006-291X. PMID 12670476.

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