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KIF2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GRY
Identifiers
Aliases	KIF2A, CDCBM3, HK2, KIF2, kinesin heavy chain member 2A, kinesin family member 2A
External IDs	OMIM: 602591; MGI: 108390; HomoloGene: 3320; GeneCards: KIF2A; OMA:KIF2A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	62,391,025 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	107,158,634 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; ganglionic eminence; ; monocyte; ; sperm; ; ventricular zone; ; external globus pallidus; ; sural nerve; ; subthalamic nucleus; ; pars compacta; ; superior vestibular nucleus;
	Top expressed in
	barrel cortex; ; blood; ; genital tubercle; ; habenula; ; tail of embryo; ; zygote; ; secondary oocyte; ; olfactory bulb; ; facial motor nucleus; ; spermatid;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; microtubule binding; ATPase activity; protein binding; cytoskeletal motor activity; ATP binding;
Cellular component	cytoplasm; cytosol; centrosome; spindle pole; membrane; kinesin complex; spindle; microtubule organizing center; sperm principal piece; spindle microtubule; nucleolus; microtubule; cytoskeleton; nucleus; nuclear body; centriole; centriolar subdistal appendage;
Biological process	cell differentiation; antigen processing and presentation of exogenous peptide antigen via MHC class II; mitotic spindle organization; nervous system development; cell division; multicellular organism development; microtubule-based movement; mitotic spindle assembly; cell cycle; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; sister chromatid cohesion; microtubule cytoskeleton organization; microtubule depolymerization; regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologs
	3796
	16563
	ENSG00000068796
	ENSMUSG00000021693
	O00139
	P28740
	NM_004520; NM_001098511; NM_001243952; NM_001243953
NM_001145779; NM_008442; NM_001374727; NM_001378936; NM_001378937;
	NM_001378938; NM_001378939; NM_001378940
	NP_001091981; NP_001230881; NP_001230882; NP_004511
NP_001139251; NP_032468; NP_001361656; NP_001365865; NP_001365866;
	NP_001365867; NP_001365868; NP_001365869
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.^[5]^[6] In mice, KIF2A is essential for proper neurogenesis and deficiency of KIF2A in mature neurons results in the loss of those neurons.^[7]

Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000068796 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021693 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D (May 1997). "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique". Genomics. 42 (1): 67–73. doi:10.1006/geno.1997.4720. PMID 9177777.
^ ^a ^b "Entrez Gene: KIF2A kinesin heavy chain member 2A".
^ Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, et al. (November 2022). "KIF2A deficiency causes early-onset neurodegeneration". Proceedings of the National Academy of Sciences of the United States of America. 119 (46): e2209714119. Bibcode:2022PNAS..11909714R. doi:10.1073/pnas.2209714119. PMC 9674219. PMID 36343267.