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KRT7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XIF
Identifiers
Aliases	KRT7, CK7, K2C7, K7, SCL, keratin 7
External IDs	OMIM: 148059; MGI: 96704; HomoloGene: 4058; GeneCards: KRT7; OMA:KRT7 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,252,186 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,328,194 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; olfactory zone of nasal mucosa; ; upper lobe of left lung; ; right lung; ; islet of Langerhans; ; right uterine tube; ; gallbladder; ; minor salivary glands; ; placenta;
	Top expressed in
	transitional epithelium of urinary bladder; ; right lung lobe; ; left lung; ; left lung lobe; ; crypt of lieberkuhn of small intestine; ; conjunctival fornix; ; submandibular gland; ; cervix; ; pyloric antrum; ; efferent ductule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; structural molecule activity;
Cellular component	cytoplasm; keratin filament; extracellular exosome; intermediate filament; nucleus; cytosol;
Biological process	viral process; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3855
	110310
	ENSG00000135480
	ENSMUSG00000023039
	P08729
	Q9DCV7
	NM_005556
	NM_033073
	NP_005547
	NP_149064
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type II cytoskeletal 7 also known as cytokeratin-7 (CK-7) or keratin-7 (K7) or sarcolectin (SCL) is a protein that in humans is encoded by the KRT7 gene.^[5]^[6]^[7] Keratin 7 is a type II keratin. It is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.

Function

Keratin-7 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.^[7]

Keratin-7 is found in simple glandular epithelia, and in transitional epithelium. Epithelial cells of the lung and breast both contain keratin-7, but some other glandular epithelia, such as those of the colon and prostate, do not.

Immunohistochemistry

Because the keratin-7 antigen is found in both healthy and neoplastic cells, antibodies to CK7 can be used in immunohistochemistry to distinguish ovarian and transitional cell carcinomas (staining positive) from colonic and prostate cancers (negative), respectively. It is commonly used together with CK20 when making such diagnoses.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135480 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023039 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rosenberg M, Fuchs E, Le Beau MM, Eddy RL, Shows TB (Aug 1991). "Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12". Cytogenetics and Cell Genetics. 57 (1): 33–8. doi:10.1159/000133109. PMID 1713141.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT7 keratin 7".
^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 173. ISBN 978-1-84110-100-2.

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