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KRT8
Identifiers
Aliases	KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO, keratin 8
External IDs	OMIM: 148060; MGI: 96705; HomoloGene: 55643; GeneCards: KRT8; OMA:KRT8 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,949,954 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,912,917 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; duodenum; ; rectum; ; placenta; ; islet of Langerhans; ; olfactory zone of nasal mucosa; ; body of pancreas; ; gallbladder; ; epithelium of bronchus; ; left lobe of thyroid gland;
	Top expressed in
	ileum; ; jejunum; ; colon; ; duodenum; ; placenta; ; stomach; ; urinary bladder; ; middle ear; ; islet of Langerhans; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-containing complex binding; scaffold protein binding; structural molecule activity; protein binding;
Cellular component	cytoplasm; cell-cell junction; nuclear matrix; dystrophin-associated glycoprotein complex; keratin filament; nucleoplasm; Z discdkac; sarcolemma; costamere; extracellular exosome; intermediate filament; nucleus; cell periphery; cytosol; apicolateral plasma membrane; intermediate filament cytoskeleton;
Biological process	extrinsic apoptotic signaling pathway; response to hydrostatic pressure; tumor necrosis factor-mediated signaling pathway; response to other organism; viral process; cell differentiation involved in embryonic placenta development; sarcomere organization; hepatocyte apoptotic process; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3856
	16691
	ENSG00000170421
	ENSMUSG00000049382
	P05787
	P11679
	NM_001256282; NM_001256293; NM_002273
	NM_031170
	NP_001243211; NP_001243222; NP_002264
	NP_112447
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18.

Utility as an immunohistochemical stain

Antibodies to CK8 (e.g. CAM 5.2) can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the breast.^[5] CAM 5.2, an antibody that reacts with an epitope found on both CK8 and CK18, is used in immunohistochemistry to demonstrate certain forms of cancer. In normal tissue, it reacts mainly with secretory epithelia, but not with squamous epithelium, such as that found in the skin, cervix, and esophagus. However, it also reacts with a range of malignant cells, including those derived from secretory epithelia, but also some squamous carcinomata, such as spindle cell carcinoma. It is considered useful in identifying microscopic metastases of breast carcinoma in lymph nodes, and in distinguishing Paget's disease from malignant melanoma. It also reacts with neuroendocrine tumors.^[6]

Keratin 8 is often used together with keratin 18 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.^[7]