Wyatt grew up in Ithaca, New York where he attended Ithaca High School, graduating in 1986.[1] He had been playing role-playing games since the late 1970s, beginning with the first Basic D&D set: "I remember pretending to be a wizard in my backyard before I picked up the basic set... I used the monster statistics in the D&D books to give us wizards something to fight in our primitive backyard live-action roleplaying game."[2] After high-school he attended Oberlin in Ohio as a religion major and graduated in 1990.[1][2] He went on to receive a Master of Divinity from Union Theological Seminary in New York City, in 1993.[1][2] He was married soon after.[1] In 1994, Wyatt began his working career as the minister of two small United Methodist churches in southeastern Ohio.[1][2]
While working as a minister Wyatt began writing in his spare time for Dragon magazine, starting with material for TSR's Masque of the Red Death setting. By 1996, Wyatt decided to change his career path: "While I was in the ministry, I started submitting adventures to Dungeon magazine... I found that my D&D work was a source of freedom and energy when ministry was more life-draining for me. When I started getting adventures and articles accepted, it was so exciting that it became clear that D&D would never again be just a hobby for me."[2] The same year he moved to Wisconsin in hopes of getting a full-time job at TSR, which did not immediately work out, but he kept writing material as a freelance author.[2] Wyatt produced work for roleplaying games such as West End's Hercules & Xena Roleplaying Game, although he felt that "D&D has always been my one true love in the gaming world... despite junior high flings with other game systems."[2] He continued to have material published in Dragon and Dungeon.
He wrote the D&D novels In the Claws of the Tiger (2006), Storm Dragon (2007), Dragon Forge (2008), Dragon War (2009), and Oath of Vigilance (2011).
In 2014, Wyatt left Dungeons & Dragons to work on the writing and creative aspects of Magic: The Gathering. Wyatt wrote the text for the series of Art of Magic: The Gathering coffee table books, which reprint illustrations from the cards with details for each plane's lore. He then wrote a series of free PDF releases called Plane Shift which adapts Magic: The Gathering for Dungeons & Dragons; the Plane Shift releases were created to allow players to use those coffee table books as campaign setting guides by providing the necessary rule adaptations.[5] Between 2016 and 2018, six "Plane Shift" articles were released: Amonkhet, Dominaria, Innistrad, Ixalan, Kaladesh, and Zendikar, along with an Ixalan-set adventure.[5][6][7] However, these articles are not considered official material for organized play.[8] In 2017, Mike Mearls wrote: "It's basically a thing James does for fun, and we don't want to burden it with needing all the work required to make it official".[9]
The positive response to the "Plane Shift" articles lead to the 2018 publication of Guildmasters' Guide to Ravnica, a full hardcover setting guide to the Magic setting of Ravnica for Dungeons & Dragons.[10][11] Wyatt was the lead designer on Guildmasters’ Guide to Ravnica (2018)[12] and he stated "this book is, essentially, Plane Shift: Ravnica".[13] Wyatt and F. Wesley Schneider were then co-leads on the design on the next crossover book Mythic Odysseys of Theros (2020) which adapts the Magic setting of Theros.[14] He is also one of the authors of the sourcebook Van Richten's Guide to Ravenloft (2021).[15]
