IgG4相关性疾病

IgG4相关性疾病
IgG4-related disease
Low power view of IgG4-related prostatitis
低倍视野下的相关性前列腺炎：前列腺间质发生密集的炎性浸润和纤维化（HE染色，100倍放大）
分类和外部资源
醫學專科免疫学/风湿病学
ICD-114A43.0
Orphanet284264
[编辑此条目的维基数据]

IgG4相关性疾病（英語：IgG4-related disease），缩写 IgG4-RD，以前称为IgG4相关全身性疾病（英語：IgG4-related systemic disease）是一类可在多种器官中发生的慢性、进行性的炎症疾病，并伴随着组织淋巴细胞浸润和浆细胞大量分泌IgG4以及不同程度的纤维化[1]。约有 51–70% 的病人在急性期血清IgG4显著升高，因而得名[2]。主要发病人群是中老年男性，口服糖皮质激素是此病的一线疗法[3]。

参考文献

  1. ^ Wallace, Zachary S.; Deshpande, Vikram; Mattoo, Hamid; Mahajan, Vinay S.; Kulikova, Maria; Pillai, Shiv; Stone, John H. IgG4-Related Disease: Clinical and Laboratory Features in One Hundred Twenty-Five Patients. Arthritis & Rheumatology. 26 August 2015, 67 (9): 2466–2475. PMC 4621270 可免费查阅. PMID 25988916. doi:10.1002/art.39205. 
  2. ^ Vikram Deshpande; Yoh Zen; John KC Chan; Eunhee E Yi; Yasuharu Sato; Tadashi Yoshino; Günter Klöppe; J Godfrey Heathcote; Arezou Khosroshahi; Judith A Ferry; Rob C Aalberse; Donald B Bloch; William R Brugge; Adrian C Bateman; Mollie N Carruthers; Suresh T Chari; Wah Cheuk; Lynn D Cornell; Carlos Fernandez-Del Castillo; David G Forcione; Daniel L Hamilos; Terumi Kamisawa; Satomi Kasashima; Shigeyuki Kawa; Mitsuhiro Kawano; Gregory Y Lauwers; Yasufumi Masaki; Yasuni Nakanuma; Kenji Notohara; Kazuichi Okazaki; Ji Kon Ryu; Takako Saeki; Dushyant V Sahani; Thomas C Smyrk; James R Stone; Masayuki Takahira; George J Webster; Motohisa Yamamoto; Giuseppe Zamboni; Hisanori Umehara; John H Stone. Consensus statement on the pathology of IgG4-related disease. Modern Pathology. 18 May 2012, 25 (9): 1181–1192. PMID 22596100. doi:10.1038/modpathol.2012.72. 
  3. ^ John H. Stone; Arezou Khosroshahi; Vikram Deshpande; John K. C. Chan; J. Godfrey Heathcote; Rob Aalberse; Atsushi Azumi; Donald B. Bloch; William R. Brugge; Mollie N. Carruthers; Wah Cheuk; Lynn Cornell; Carlos Fernandez-Del Castillo; Judith A. Ferry; David Forcione; Günter Klöppe; Daniel L. Hamilos; Terumi Kamisawa; Satomi Kasashima; Shigeyuki Kawa; Mitsuhiro Kawano; Yasufumi Masaki; Kenji Notohara; Kazuichi Okazaki; Ji Kon Ryu; Takako Saeki; Dushyant Sahani; Yasuharu Sato; Thomas Smyrk; James R. Stone; Masayuki Takahira; Hisanori Umehara; George Webster; Motohisa Yamamoto; Eunhee Yi; Tadashi Yoshino; Giuseppe Zamboni; Yoh Zen; Suresh Chari. Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations. Arthritis & Rheumatism. October 2012, 64 (10): 3061–3067. PMC 5963880 可免费查阅. PMID 22736240. doi:10.1002/art.34593. 

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