局部的非编码RNA类可以招募转录机制对附近蛋白编码基因的转录加以调控。TLS(英語:translocated in liposarcoma)是一种结合RNA的蛋白,它结合到CREB结合蛋白和组蛋白乙酰基转移酶p300上并抑制这两者在靶基因周期蛋白D1上的活性,从而起到抑制后者的作用。作为DNA受损信号的响应,长链非编码RNA以低水平表达出来并拴在周期蛋白D1基因的5'调控区域上,这指导了TLS招募到周期蛋白D1启动子上(Wang 2008)。除此之外,这些局部的非编码RNA作为配体调控TLS的活性。从更广泛的层面上说,这一机制使得细胞可以利用RNA结合蛋白(它们组成了哺乳动物蛋白质组中的最庞大的种类之一)并在转录程序控制中整合它们的功能。
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