小卡哈爾體RNA

小卡哈爾體RNA
小卡哈爾體RNA1的次級結構
识别符
代号 SCARNA1
Rfam RF00553
其他数据
RNA类型 snoRNA、scaRNA
動物

小卡哈爾體RNA(Small Cajal body-specific RNA,簡稱scaRNA)是動物細胞核卡哈爾體中的一類H/ACA匣(H/ACA box)snoRNA[1],卡哈爾體為細胞組裝核小核糖核蛋白(snRNP)的位置。ScaRNA可在卡哈爾體中參與U1剪接體RNA英语U1 spliceosomal RNAU2剪接體RNA英语U2 spliceosomal RNAU4剪接體RNA英语U4 spliceosomal RNAU5剪接體RNA英语U5 spliceosomal RNAU12次要剪接體RNA英语U12 minor spliceosomal RNA等剪接體RNA的甲基化2'-O-甲基化)與假尿苷化修飾,另外果蠅的scaRNA還參與28S rRNA的修飾[2]。最早被發現的小卡哈爾體為U85 RNA,於2011年在人類細胞中發現[3]

多數snoRNA與scaRNA均位於內含子中,隨其他基因一起轉錄,但有少數scaRNA為RNA聚合酶II獨立轉錄[4],此類scaRNA中有數個還可被DGCR8Drosha切割成更小的RNA碎片,這些碎片於核仁中可與其他蛋白組成RNP,可影響snoRNA對rRNA的修飾[5]

參考文獻

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