厄妥索单抗

厄妥索单抗
单克隆抗体
种类三功能抗体（英语：Trifunctional antibody）
目標HER2/neu, CD3
臨床資料
商品名（英语：Drug nomenclature）Rexomun
ATC碼
  • 未分配
识别信息
CAS号509077-99-0  checkY
ChemSpider
  • none
UNII

厄妥索单抗（INN：Ertumaxomab），或译厄马索单抗，商品名Rexomun，是一种三功能单克隆抗体，设计用于治疗乳癌和腹膜癌病（英语：Peritoneal carcinomatosis）。[1][2]它通过将T淋巴细胞和巨噬细胞与癌细胞连接起来发挥作用。[3]

由于费森尤斯开发计划的改变，评估乳癌治疗的II期临床试验被终止。[4]（以便他们可以专注于其他产品如卡妥索单抗（英语：catumaxomab）（商品名Removab）。[5]:35）

参考资料

  1. ^ Kiewe, Philipp; Thiel, Eckhard. Ertumaxomab: a trifunctional antibody for breast cancer treatment. Expert Opinion on Investigational Drugs. 2008-10, 17 (10) [2024-01-23]. ISSN 1744-7658. PMID 18808314. doi:10.1517/13543784.17.10.1553. （原始内容存档于2024-04-12）. 
  2. ^ ASCO-Meeting: Fresenius Biotech presents clinical trial results of new antibodies at the world's largest cancer convention | FSE. www.fresenius.com. [2024-01-23]. （原始内容存档于2024-01-23） （英语）. 
  3. ^ Ertumaxomab Overview - Creative Biolabs. www.creativebiolabs.net. [2024-01-23]. 
  4. ^ ClinicalTrials.gov: Phase II Study With the Trifunctional Antibody Ertumaxomab to Treat Metastatic Breast Cancer After Progression on Trastuzumab Therapy. [2024-01-23]. （原始内容存档于2016-04-10）. 
  5. ^ 2009 Consolidated Financial Statements and Management Report of Fresenius SE (PDF). [2016-03-20]. （原始内容 (PDF)存档于2016-03-31）. 

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