利妥木单抗

利妥木单抗
单克隆抗体
种类完整抗体
目標HGF（英语：Hepatocyte growth factor）
臨床資料
ATC碼
  • 未分配
识别信息
CAS号872514-65-3  ☒N
ChemSpider
  • none
UNII
KEGG
化学信息
化学式C6464H9932N1708O2010S46
摩尔质量145,207.27 g·mol−1

利妥木单抗（INN：Rilotumumab：开发代号：AMG102）是一种人单克隆抗体，设计用于治疗实体瘤。[1]

利妥木单抗一直由安进公司开发，直到2014年11月，安进宣布停止该化合物治疗晚期胃癌的所有临床试验（包括两项III期研究），因为其中一项试验发现与仅接受化疗的患者相比，同时服用利妥木单抗和化疗的患者死亡人数增加。[2][3]

参考资料

  1. ^ Statement On A Nonproprietary Name Adopted By The USAN Council: Rilotumumab (PDF). American Medical Association. [2024-01-24]. （原始内容存档 (PDF)于2012-03-05）. 
  2. ^ Amgen scraps trials of drug for advanced stomach cancer. yahoo.com. 24 Nov 2014 [24 Nov 2014]. （原始内容存档于2024-01-24）. 
  3. ^ Amgen Halts Rilotumumab Trials in Advanced Gastric Cancer. 24 November 2014 [2024-01-24]. （原始内容存档于2024-01-24）. 

Read other articles:

Resident Evil (1996 video game)

Survival horror game Resident Evil 1 redirects here. For the GameCube remake, see Resident Evil (2002 video game). For the first film in the Resident Evil film series, see Resident Evil (film). For other uses, see Resident Evil (disambiguation). RE1 redirects here. For other uses, see RE1 (disambiguation). 1996 video gameResident EvilWestern cover art by Bill SienkiewiczDeveloper(s)Capcom[a]Publisher(s) Capcom PlayStationJP/NA: CapcomPAL: Virgin Interactive EntertainmentMicrosoft Wind...

 

Camphor

Toxic, waxy, and transparent aromatic organic compound Not to be confused with samphor. For other uses, see Camphor (disambiguation). Camphor[1][2] (+)- and (−)-camphor Names IUPAC name 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one Other names 2-Bornanone; Bornan-2-one; 2-Camphanone; Formosa Identifiers CAS Number 76-22-2 Y464-49-3 (R) Y464-48-2 (S) Y 3D model (JSmol) Interactive imageInteractive image 3DMet B04902 Beilstein Reference 1907611 ChEBI CHEB...

 

Aforisme

Artikel ini perlu diwikifikasi agar memenuhi standar kualitas Wikipedia. Anda dapat memberikan bantuan berupa penambahan pranala dalam, atau dengan merapikan tata letak dari artikel ini. Untuk keterangan lebih lanjut, klik [tampil] di bagian kanan. Mengganti markah HTML dengan markah wiki bila dimungkinkan. Tambahkan pranala wiki. Bila dirasa perlu, buatlah pautan ke artikel wiki lainnya dengan cara menambahkan [[ dan ]] pada kata yang bersangkutan (lihat WP:LINK untuk keterangan lebih lanjut...

Phosphatidic acid

Class of lipid compounds Phosphatidic acids are anionic phospholipids important to cell signaling and direct activation of lipid-gated ion channels. Hydrolysis of phosphatidic acid gives rise to one molecule each of glycerol and phosphoric acid and two molecules of fatty acids. They constitute about 0.25% of phospholipids in the bilayer.[1] Structure General chemical structure of phosphatidic acids Phosphatidic acid consists of a glycerol backbone, with, in general, a saturated fatty ...

 

Peter R. Livingston

Pour les autres membres de la famille, voir Famille Livingston. Cet article est une ébauche concernant un homme politique américain. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Peter R. Livingston Fonctions Lieutenant-gouverneur de l'État de New York 1828 – 1828(moins d’un an) Speaker de l'Assemblée de l'État de New York 1823 – 1823(moins d’un an) Biographie Nationalité États-Unis modifier...

 

Tim nasional futsal Belanda

BelandaJulukanOranjeHollandThe Flying Dutchmen A Clockwork Orange La Machina NaranjaAsosiasiAsosiasi Sepak Bola Kerajaan BelandaKonfederasiUEFA (Eropa)PelatihMarcel LoosveldKode FIFANED Warna pertama Warna kedua Peringkat FIFATerkini 34 1 (22 September 2021)[1]Pertandingan internasional pertama Belgia 7–2 Belanda (Genk, Belgia; 22 April 1977)Piala DuniaPenampilan4 (pertama kali pada 1989)Hasil terbaik 2 (1989)Kejuaraan EropaPenampilan5 (pertama kali pada 1996)Hasil terbaik...

Thure de Thulstrup

Swedish-born American illustrator de Thulstrup in 1901 Thure de Thulstrup (April 5, 1848 – June 9, 1930), born Bror Thure Thulstrup in Sweden,[1] was an American illustrator with contributions for numerous magazines, including three decades of work for Harper's Weekly.[2] Thulstrup primarily illustrated historical military scenes. Early life and education Thulstrup was born in Stockholm, Sweden.[3] His father was Sweden's Secretary of the Navy amongst other such posi...

 

Марков, Леонид Васильевич

В Википедии есть статьи о других людях с такой фамилией, см. Марков. Леонид Марков Имя при рождении Леонид Васильевич Марков Дата рождения 13 декабря 1927(1927-12-13)[1][2] Место рождения с. Алексеевка,Казахская АССР, СССР Дата смерти 1 марта 1991(1991-03-01)[3] (63 года) Место смер...

 

Сибирский горный козёл

Сибирский горный козёл Научная классификация Домен:ЭукариотыЦарство:ЖивотныеПодцарство:ЭуметазоиБез ранга:Двусторонне-симметричныеБез ранга:ВторичноротыеТип:ХордовыеПодтип:ПозвоночныеИнфратип:ЧелюстноротыеНадкласс:ЧетвероногиеКлада:АмниотыКлада:СинапсидыКла�...

Juice Robinson

Juice RobinsonRobinson pada Februari 2016Nama lahirJoseph Ryan RobinsonLahir10 April 1989 (umur 35)[1]Joliet, Illinois, A.S.PasanganToni Storm ​(m. 2022)​Karier gulat profesionalNama ringCJPCJ ParkerJuiceJuice Robinson[2]Red Death MaskTinggi6 ft 3 in (1,91 m)[1][3]Berat218 pon (99 kg)[1][3]Asal dariJoliet, Illinois[3][4]Dilatih olehTruth Martini[5]Danny DanielsWWE...

 

Torre de' Busi

Torre de' Busicomune LocalizzazioneStato Italia Regione Lombardia Provincia Bergamo AmministrazioneCapoluogoSan Michele SindacoEleonora Ninkovic (lista civica) dal 7-6-2009 TerritorioCoordinatedel capoluogo45°46′42.95″N 9°29′04.24″E / 45.778596°N 9.48451°E45.778596; 9.48451 (Torre de' Busi)Coordinate: 45°46′42.95″N 9°29′04.24″E / 45.778596°N 9.48451°E45.778596; 9.48451 (Torre de' Busi) Altitudine472 m&...

 

Baroness Mary Vetsera

Baroness Mary VetseraLahirBaroness Marie Alexandrine von Vetsera(1871-03-19)19 Maret 1871Wina, Austria-HungariaMeninggal30 Januari 1889(1889-01-30) (umur 17)Mayerling, Austria Hilir, Austria-HungariaGelarBaroness von VetseraPasanganRudolf, Putra Mahkota AustriaOrang tuaBaron Albin von VetseraHélène Baltazzi Baroness Marie Alexandrine von Vetsera (19 Maret 1871 – 30 Januari 1889) adalah seorang anggota masyarakat dua (bangsawan baru) Austria dan salah satu gundik Putra ...

乌克兰总理

 烏克蘭總理Прем'єр-міністр України烏克蘭國徽現任杰尼斯·什米加尔自2020年3月4日任命者烏克蘭總統任期總統任命首任維托爾德·福金设立1991年11月后继职位無网站www.kmu.gov.ua/control/en/（英文） 乌克兰 乌克兰政府与政治系列条目 宪法 政府 总统 弗拉基米尔·泽连斯基 總統辦公室 国家安全与国防事务委员会 总统代表（英语：Representatives of the President of Ukraine） 总...

 

Kekaisaran Massina

Peta Massina. Kekaisaran Massina (Maasina atau Macina: juga disebut: Dina dari Massina, dan Kekhalifahan Hamdullahi) adalah negara Jihad Fulbe awal abad ke-19 yang berpusat di Macina di wilayah yang sekarang merupakan Region Mopti dan Ségou di Mali. Ibu kota kekaisaran ini adalah Hamdullahi. Pranala luar Nineteenth Century Timeline of Western and Central Sudan History of Mali (French language) Diarsipkan 2005-03-26 di Wayback Machine. lbsKerajaan-kerajaan Sahel Alodia Bagirmi Bamana Baol Bor...

 

Birdgirl (TV series)

American adult animated superhero comedy television series For other uses, see Birdgirl. BirdgirlTitle cardGenre Animated sitcom Comedy Superhero Created by Michael Ouweleen Erik Richter Based onHarvey Birdman, Attorney at Law by Michael OuweleenErik RichterHanna-Barbera cartoons/charactersDeveloped by Erik Richter Christina Miller Directed byRich Ferguson-Hull[1]Starring Paget Brewster Rob Delaney Sonia Denis Kether Donohue John Doman Julie Dove Negin Farsad Tony Hale River L. Ramire...

WDIA

Radio station in Memphis, TennesseeWDIAMemphis, TennesseeBroadcast areaMemphis metropolitan areaFrequency1070 kHzBrandingAM 1070 WDIAProgrammingFormatUrban oldies/classic soulOwnershipOwneriHeartMedia(iHM Licenses, LLC)Sister stationsKJMSKWNWWEGRWHAL-FMWHRKWRECHistoryFirst air dateJune 7, 1947(77 years ago) (1947-06-07)Call sign meaningDiane, name of original owner's daughterWe Did It Again (when owners also launched similar station in Jackson, Mississippi, after World War II)Techn...

 

Ausonia, Lazio

Comune in Lazio, ItalyAusoniaComuneComune di Ausonia Coat of armsLocation of Ausonia AusoniaLocation of Ausonia in ItalyShow map of ItalyAusoniaAusonia (Lazio)Show map of LazioCoordinates: 41°21′N 13°45′E / 41.350°N 13.750°E / 41.350; 13.750CountryItalyRegionLazioProvinceFrosinone (FR)FrazioniMadonna del Piano, SelvacavaGovernment • MayorBenedetto CardilloArea[1] • Total20 km2 (8 sq mi)Elevation178 m (584 ...

 

Élections législatives de 1988 dans le Bas-Rhin

1986 1993 Élections législatives de 1988 dans le Bas-Rhin 9 sièges de députés à l'Assemblée nationale 5 et 12 juin 1988 Corps électoral et résultats Inscrits au 1er tour 618 313 Votants au 1er tour 384 434   62,17 %  14,8 Votes exprimés au 1er tour 384 434 Inscrits au 2d tour 401 072 Votants au 2d tour 249 332   62,17 % Votes exprimés au 2d tour 241 889 Union du Rassemblement et du Centre Liste Rassemblement pour la Répub...

Symphony No. 2 (Lutosławski)

Symphony by Witold Lutosławski Symphony No. 2by Witold LutosławskiWitold Lutosławski in 1992Composed1965–1967Duration30 min.Movements2PremiereDate9 June 1966 (1966-06-09)LocationKatowiceConductorAntoni WitPerformersPolish Radio Symphony Orchestra The Symphony No. 2 by the Polish composer Witold Lutosławski is an orchestral composition in two movements written between 1965 and 1967. The work exhibits Lutosławski's technique of limited aleatoricism, where the individual in...

 

كأس ألبانيا 1972–73

يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (نوفمبر 2019) كأس ألبانيا 1972–73 تفاصيل الموسم كأس ألبانيا  البلد ألبانيا  المنظم اتحاد ألبانيا لكرة القدم  البط...