乐德木单抗

乐德木单抗
单克隆抗体
种类完整抗体
目標转化生长因子β2（英语：TGF beta 2）
臨床資料
ATC碼
  • 未分配
法律規範狀態
法律規範
  • 开发停止
识别信息
CAS号285985-06-0  checkY[NIH]
ChemSpider
  • none
UNII

乐德木单抗（INN：lerdelimumab；开发代号：CAT-152）是一种人单克隆抗体，也是一种针对转化生长因子β2（英语：TGF beta 2）的免疫抑制剂。[1][2]

该药物的开发是为了减少青光眼引流手术（英语：Glaucoma surgery）后的疤痕。[3]由于该病症的试验结果不成功，开发于2005年底停止。[4]

参考资料

  1. ^ Cordeiro, M. Francesca. Technology evaluation: lerdelimumab, Cambridge Antibody Technology. Current Opinion in Molecular Therapeutics. 2003-04, 5 (2). ISSN 1464-8431. PMID 12772512. 
  2. ^ Mead, Anna L.; Wong, Tina T. L.; Cordeiro, M. Francesca; Anderson, Ian K.; Khaw, Peng T. Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Investigative Ophthalmology & Visual Science. 2003-08, 44 (8) [2024-05-26]. ISSN 0146-0404. PMID 12882787. doi:10.1167/iovs.02-0978. （原始内容存档于2024-05-26）. 
  3. ^ Lerdelimumab. Drugs in R&D. 1 February 2002, 3 (2): 106–8. PMID 12001808. doi:10.2165/00126839-200203020-00006. 
  4. ^ CAT abandons Trabio after second clinical trial failure. The Pharma Letter. 28 March 2005. 

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