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Klobenzoreks
Klinički podaci
Drugs.com	Monografija
Identifikatori
CAS broj	13364-32-4
ATC kod	A08AA08 (WHO)
PubChem	CID 71675
ChemSpider	64732
UNII	4A5352XI2A
KEGG	D07115
ChEMBL	CHEMBL1213251
Sinonimi	(+)-N-(2-chlorobenzyl)amphetamine
Hemijski podaci
Formula	C16H18ClN
Molarna masa	259,774
	SMILES CC(Cc1ccccc1)NCc2ccccc2Cl; ;
	InChI InChI=1S/C16H18ClN/c1-13(11-14-7-3-2-4-8-14)18-12-15-9-5-6-10-16(15)17/h2-10,13,18H,11-12H2,1H3 ; Key:LRXXRIXDSAEIOR-UHFFFAOYSA-N ;

Klobenzoreks (Asenlix, Dinintel, Finedal, Rexigen) je stimulantni lek amfetaminske hemijske klase koji se koristi kao supresor apetita.^[1] Ovaj lek se legalno distribuira u Meksiku pod trgovačkim imenom Asenliks kompanije Aventis.

Hemijski, klobenzoreks je N-supstituisani prolek amfetamina koji se prvenstveno metaboliše u 4-hidroksiklobenzoreks nakon ingestacije; međutim, male količine se takođe metabolišu u dekstroamfetamin.^[2] U komercijalnoj proizvodnji, klobenzoreks se isporučuje kao hidrohloridna so u zeleno obojenim kapsulama. Ovaj lek je ušao u upotrebu kao anoreksik na recepat tokom 1970-ih.

Osobine

Klobenzoreks je organsko jedinjenje, koje sadrži 16 atoma ugljenika i ima molekulsku masu od 259,774 Da.

Osobina	Vrednost
Broj akceptora vodonika	1
Broj donora vodonika	1
Broj rotacionih veza	5
Particioni koeficijent^[3] (ALogP)	4,3
Rastvorljivost^[4] (logS, log(mol/L))	-5,8
Polarna površina^[5] (PSA, Å²)	12,0

Reference

^ Young R, Darmani NA, Elder EL, Dumas D, Glennon RA (фебруар 1997). „Clobenzorex: evidence for amphetamine-like behavioral actions”. Pharmacology, Biochemistry, and Behavior. 56 (2): 311—316. PMID 9050090. S2CID 37062225. doi:10.1016/s0091-3057(96)00329-2.
^ Cody JT (2005). „Amphetamines: methods of forensic analysis.”. Ур.: Smith F, Athanaselis SS. Handbook of Forensic Drug Analysis. Elsevier. стр. 357—451 (430). ISBN 978-0-08-047289-8. „Amphetamine produced from the metabolism of clobenzorex has been shown to be the d-enantiomer only ...”
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Clobenzorex

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[pmid9050090-1] Young R, Darmani NA, Elder EL, Dumas D, Glennon RA (фебруар 1997). „Clobenzorex: evidence for amphetamine-like behavioral actions”. Pharmacology, Biochemistry, and Behavior. 56 (2): 311—316. PMID 9050090. S2CID 37062225. doi:10.1016/s0091-3057(96)00329-2.

[2] Cody JT (2005). „Amphetamines: methods of forensic analysis.”. Ур.: Smith F, Athanaselis SS. Handbook of Forensic Drug Analysis. Elsevier. стр. 357—451 (430). ISBN 978-0-08-047289-8. „Amphetamine produced from the metabolism of clobenzorex has been shown to be the d-enantiomer only ...”

[3] Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.

[4] Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[5] Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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