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Dostupne proteinske strukture:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Domen inhibitora apoptoze
Domen inhibitora apoptoze
	NMR rešenje strukture BIR domena ljudskog BIRC2 proteina. N-terminus = plavo, C-terminus = crveno, dok je cink prikazan sivim sferama.
Identifikatori
Simbol	BIR
Pfam	PF00653
InterPro	IPR001370
PROSITE	PS50143
SCOP	1qbh
SUPERFAMILY	1qbh
Pfam
Dostupne proteinske strukture:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Domen inhibitora apoptoze (IAP ponavljanje, Bakulovirusni inhibitor apoptoznog proteinskog ponavljanja, BIR) je strukturni motiv prisutan u proteinima koji učestvuju u apoptozi, citokinskoj produkciji, i segregaciji hromozoma.^[2] Proteini koji sadrže BIR su poznati kao inhibitori apoptoze (IAP), kao i BIRP ili BIRC (engl. BIR-containing proteins). U te proteine se ubrajaju BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) i BIRC6.^[2]^[3]

BIR domeni pripadaju familiji domena cinkovog prsta i karakteristično imaju brojne nepromenljive aminokiselinske ostatke, uključujući tri konzervirana cisteina je jedan konzervirani histidin, sa koordinatno vezanim jonom cinka.^[4] Oni se tipično sastoje od 4-5 alfa heliksa i trolančane beta ravni.

Reference

^ PDB: 1QBH;Hinds MG, Norton RS, Vaux DL, Day CL (1999). „Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat”. Nat. Struct. Biol. 6 (7): 648—51. PMID 10404221. doi:10.1038/10701.
^ ^а ^б Silke J, Vaux DL (2001). „Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis”. J. Cell. Sci. 114 (Pt 10): 1821—7. PMID 11329368.
^ Verhagen AM, Coulson EJ, Vaux DL (2001). „Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs”. Genome Biol. 2 (7): REVIEWS3009. PMC 139420 . PMID 11516343. doi:10.1186/gb-2001-2-7-reviews3009.
^ Birnbaum MJ, Clem RJ, Miller LK (1994). „An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs”. J. Virol. 68 (4): 2521—8. PMC 236730 . PMID 8139034.

Spoljašnje veze

Eukaryotic Linear Motif resource motif class LIG_BIR_II_1
Eukaryotic Linear Motif resource motif class LIG_BIR_III_1
Eukaryotic Linear Motif resource motif class LIG_BIR_III_2
Eukaryotic Linear Motif resource motif class LIG_BIR_III_3
Eukaryotic Linear Motif resource motif class LIG_BIR_III_4

Ovaj artikal sadrži tekst iz javnog vlasništva Pfam i InterPro IPR001370

[pmid10404221-1] PDB: 1QBH;Hinds MG, Norton RS, Vaux DL, Day CL (1999). „Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat”. Nat. Struct. Biol. 6 (7): 648—51. PMID 10404221. doi:10.1038/10701.

[pmid11329368-2] а ^б Silke J, Vaux DL (2001). „Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis”. J. Cell. Sci. 114 (Pt 10): 1821—7. PMID 11329368.

[pmid11516343-3] Verhagen AM, Coulson EJ, Vaux DL (2001). „Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs”. Genome Biol. 2 (7): REVIEWS3009. PMC 139420 . PMID 11516343. doi:10.1186/gb-2001-2-7-reviews3009.

[pmid8139034-4] Birnbaum MJ, Clem RJ, Miller LK (1994). „An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs”. J. Virol. 68 (4): 2521—8. PMC 236730 . PMID 8139034.

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