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Bakulovirni protein 2, koji sadrži IAP ponavljanje
Bakulovirni protein 2, koji sadrži IAP ponavljanje
	PDB prikaz baziran na 1qbh.
Dostupne strukture
	1QBH, 2L9M, 3D9T, 3D9U, 3M1D, 3MUP, 3OZ1, 3T6P, 3UW4
Identifikatori
Simboli	BIRC2; API1; HIAP2; Hiap-2; MIHB; RNF48; c-IAP1; cIAP1
Vanjski ID	OMIM: 601712 MGI: 1197009 HomoloGene: 900 GeneCards: BIRC2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost transkripcionog koaktivatoraa; • aktivnost ligaze ubikvitinskog protein; • proteinsko vezivanje; • vezivanje jona cinka; • vezivanje proteinskog N-terminusa;
Celularna komponenta	• nukleus; • citozol; • unutrašnja strana ćelijske membrane; • kompleks CD40 receptora;
Biološki proces	• proteinska poliubikvitinacija; • razvoj materice; • transkripcija, DNK zavisna; • regulacija transkripcije, DNK zavisna; • apoptotički proces; • antiapoptoza;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	329
Ensembl	ENSG00000110330
UniProt	Q13490
RefSeq (mRNA)	NM_001166.4
RefSeq (protein)	NP_001157.1
Lokacija (UCSC)	Chr 11:; 102.22 - 102.25 Mb
PubMed pretraga	[1]

Bakuloviralni protein 2 koji sadrži IAP ponavljanje (cIAP1) je protein koji je kod ljudi kodiran BIRC2 genom.^[1]^[2]

cIAP1 je član familije inhibitora apoptoze, koja inhibira apoptozu putem ometanja dejstva kaspaza.

Interakcije

BIRC2 formira interakcije sa HtrA serinskom peptidazom 2,^[3]^[4] Diablo homologom,^[3]^[5] TRAF1,^[6]^[7]^[8] TRAF2,^[6]^[7]^[8]^[9]^[10]^[11] HSP90B1,^[12] RIPK1,^[13] Kaspaza-9,^[14] TNFSF14,^[15] GSPT1,^[3] RIPK2^[16]^[17] i Ubikvitin C.^[12]^[13]^[18]

Reference

^ Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (1996). „Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes”. Nature. 379 (6563): 349—53. PMID 8552191. doi:10.1038/379349a0.
^ Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (1996). „The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins”. Cell. 83 (7): 1243—52. PMID 8548810. doi:10.1016/0092-8674(95)90149-3.
^ ^а ^б ^в Hegde, Ramesh; Srinivasula Srinivasa M; Datta Pinaki; Madesh Muniswamy (2003). Wassell Richard, Zhang ZhiJia, Cheong NaEun, Nejmeh Julie, Fernandes-Alnemri Teresa, Hoshino Shin-ichi, Alnemri Emad S. „The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein”. J. Biol. Chem. United States. 278 (40): 38699—706. ISSN 0021-9258. PMID 12865429. doi:10.1074/jbc.M303179200.
^ Verhagen, Anne M; Silke John; Ekert Paul G (2002). Pakusch Miha, Kaufmann Hitto, Connolly Lisa M, Day Catherine L, Tikoo Anjali, Burke Richard, Wrobel Carolyn, Moritz Robert L, Simpson Richard J, Vaux David L. „HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins”. J. Biol. Chem. United States. 277 (1): 445—54. ISSN 0021-9258. PMID 11604410. doi:10.1074/jbc.M109891200.
^ Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL (2000). „Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins”. Cell. United States. 102 (1): 43—53. ISSN 0092-8674. PMID 10929712. doi:10.1016/S0092-8674(00)00009-X.
^ ^а ^б Roy, N; Deveraux Q L; Takahashi R; Salvesen G S; Reed J C (1997). „The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases”. EMBO J. ENGLAND. 16 (23): 6914—25. ISSN 0261-4189. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.
^ ^а ^б Shu, H B; Takeuchi M; Goeddel D V (1996). „The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex”. Proc. Natl. Acad. Sci. U.S.A. United States. 93 (24): 13973—8. ISSN 0027-8424. PMC 19479 . PMID 8943045. doi:10.1073/pnas.93.24.13973.
^ ^а ^б Li, Xiaoming; Yang Yili; Ashwell Jonathan D (2002). „TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2”. Nature. England. 416 (6878): 345—7. ISSN 0028-0836. PMID 11907583. doi:10.1038/416345a.
^ Rual, Jean-François; Venkatesan Kavitha; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. England. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.
^ Uren, A G; Pakusch M; et al. (1996). „Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors”. Proc. Natl. Acad. Sci. U.S.A. United States. 93 (10): 4974—8. ISSN 0027-8424. PMC 39390 . PMID 8643514. doi:10.1073/pnas.93.10.4974.
^ Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (2000). „Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein”. J. Biol. Chem. United States. 275 (15): 11114—20. ISSN 0021-9258. PMID 10753917. doi:10.1074/jbc.275.15.11114.
^ ^а ^б Didelot C, Lanneau D, Brunet M, Bouchot A, Cartier J, Jacquel A, Ducoroy P, Cathelin S, Decologne N, Chiosis G, Dubrez-Daloz L, Solary E, Garrido C (2008). „Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation”. Cell Death Differ. England. 15 (5): 859—66. ISSN 1350-9047. PMID 18239673. doi:10.1038/cdd.2008.5.
^ ^а ^б Bertrand, Mathieu J M; Milutinovic Snezana; et al. (2008). „cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination”. Mol. Cell. United States. 30 (6): 689—700. PMID 18570872. doi:10.1016/j.molcel.2008.05.014.
^ Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC (1998). „IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases”. EMBO J. ENGLAND. 17 (8): 2215—23. ISSN 0261-4189. PMC 1170566 . PMID 9545235. doi:10.1093/emboj/17.8.2215.
^ Kuai, June; Nickbarg Elliott; et al. (2003). „Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis”. J. Biol. Chem. United States. 278 (16): 14363—9. ISSN 0021-9258. PMID 12571250. doi:10.1074/jbc.M208672200.
^ McCarthy JV, Ni J, Dixit VM (1998). „RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase”. J. Biol. Chem. United States. 273 (27): 16968—75. ISSN 0021-9258. PMID 9642260. doi:10.1074/jbc.273.27.16968.
^ Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (1998). „Identification of CARDIAK, a RIP-like kinase that associates with caspase-1”. Curr. Biol. ENGLAND. 8 (15): 885—8. ISSN 0960-9822. PMID 9705938. doi:10.1016/S0960-9822(07)00352-1.
^ Sekine, Keiko; Takubo Kohei; et al. (2008). „Small molecules destabilize cIAP1 by activating auto-ubiquitylation”. J. Biol. Chem. United States. 283 (14): 8961—8. ISSN 0021-9258. PMID 18230607. doi:10.1074/jbc.M709525200.

Literatura

Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene. 138 (1-2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Uren AG; Pakusch M; Hawkins CJ; et al. (1996). „Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.”. Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974—8. PMC 39390 . PMID 8643514. doi:10.1073/pnas.93.10.4974.
Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG (1997). „Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization.”. Genomics. 37 (3): 404—6. PMID 8938457. doi:10.1006/geno.1996.0579.
Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene. 200 (1-2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Roy N; Deveraux QL; Takahashi R; et al. (1998). „The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.”. EMBO J. 16 (23): 6914—25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.
Deveraux QL; Roy N; Stennicke HR; et al. (1998). „IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.”. EMBO J. 17 (8): 2215—23. PMC 1170566 . PMID 9545235. doi:10.1093/emboj/17.8.2215.
McCarthy JV, Ni J, Dixit VM (1998). „RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.”. J. Biol. Chem. 273 (27): 16968—75. PMID 9642260. doi:10.1074/jbc.273.27.16968.
Young SS; Liston P; Xuan JY; et al. (1999). „Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2.”. Mamm. Genome. 10 (1): 44—8. PMID 9892732. doi:10.1007/s003359900940.
Hinds MG, Norton RS, Vaux DL, Day CL (1999). „Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.”. Nat. Struct. Biol. 6 (7): 648—51. PMID 10404221. doi:10.1038/10701.
Verhagen AM; Ekert PG; Pakusch M; et al. (2000). „Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.”. Cell. 102 (1): 43—53. PMID 10929712. doi:10.1016/S0092-8674(00)00009-X.
Vucic D; Stennicke HR; Pisabarro MT; et al. (2001). „ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.”. Curr. Biol. 10 (21): 1359—66. PMID 11084335. doi:10.1016/S0960-9822(00)00781-8.
Werneburg BG; Zoog SJ; Dang TT; et al. (2001). „Molecular characterization of CD40 signaling intermediates.”. J. Biol. Chem. 276 (46): 43334—42. PMID 11562359. doi:10.1074/jbc.M104994200.
Suzuki Y; Imai Y; Nakayama H; et al. (2001). „A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.”. Mol. Cell. 8 (3): 613—21. PMID 11583623. doi:10.1016/S1097-2765(01)00341-0.
Verhagen AM; Silke J; Ekert PG; et al. (2002). „HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.”. J. Biol. Chem. 277 (1): 445—54. PMID 11604410. doi:10.1074/jbc.M109891200.
Mellström B; Ceña V; Lamas M; et al. (2002). „Gas1 is induced during and participates in excitotoxic neuronal death.”. Mol. Cell. Neurosci. 19 (3): 417—29. PMID 11906213. doi:10.1006/mcne.2001.1092.
Li X, Yang Y, Ashwell JD (2002). „TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.”. Nature. 416 (6878): 345—7. PMID 11907583. doi:10.1038/416345a.
Imoto I; Tsuda H; Hirasawa A; et al. (2002). „Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy.”. Cancer Res. 62 (17): 4860—6. PMID 12208731.

[pmid8552191-1] Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (1996). „Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes”. Nature. 379 (6563): 349—53. PMID 8552191. doi:10.1038/379349a0.

[pmid8548810-2] Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (1996). „The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins”. Cell. 83 (7): 1243—52. PMID 8548810. doi:10.1016/0092-8674(95)90149-3.

[pmid12865429-3] а ^б ^в Hegde, Ramesh; Srinivasula Srinivasa M; Datta Pinaki; Madesh Muniswamy (2003). Wassell Richard, Zhang ZhiJia, Cheong NaEun, Nejmeh Julie, Fernandes-Alnemri Teresa, Hoshino Shin-ichi, Alnemri Emad S. „The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein”. J. Biol. Chem. United States. 278 (40): 38699—706. ISSN 0021-9258. PMID 12865429. doi:10.1074/jbc.M303179200.

[pmid11604410-4] Verhagen, Anne M; Silke John; Ekert Paul G (2002). Pakusch Miha, Kaufmann Hitto, Connolly Lisa M, Day Catherine L, Tikoo Anjali, Burke Richard, Wrobel Carolyn, Moritz Robert L, Simpson Richard J, Vaux David L. „HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins”. J. Biol. Chem. United States. 277 (1): 445—54. ISSN 0021-9258. PMID 11604410. doi:10.1074/jbc.M109891200.

[pmid10929712-5] Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL (2000). „Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins”. Cell. United States. 102 (1): 43—53. ISSN 0092-8674. PMID 10929712. doi:10.1016/S0092-8674(00)00009-X.

[pmid9384571-6] а ^б Roy, N; Deveraux Q L; Takahashi R; Salvesen G S; Reed J C (1997). „The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases”. EMBO J. ENGLAND. 16 (23): 6914—25. ISSN 0261-4189. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.

[pmid8943045-7] а ^б Shu, H B; Takeuchi M; Goeddel D V (1996). „The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex”. Proc. Natl. Acad. Sci. U.S.A. United States. 93 (24): 13973—8. ISSN 0027-8424. PMC 19479 . PMID 8943045. doi:10.1073/pnas.93.24.13973.

[pmid11907583-8] а ^б Li, Xiaoming; Yang Yili; Ashwell Jonathan D (2002). „TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2”. Nature. England. 416 (6878): 345—7. ISSN 0028-0836. PMID 11907583. doi:10.1038/416345a.

[pmid16189514-9] Rual, Jean-François; Venkatesan Kavitha; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. England. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.

[pmid8643514-10] Uren, A G; Pakusch M; et al. (1996). „Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors”. Proc. Natl. Acad. Sci. U.S.A. United States. 93 (10): 4974—8. ISSN 0027-8424. PMC 39390 . PMID 8643514. doi:10.1073/pnas.93.10.4974.

[pmid10753917-11] Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (2000). „Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein”. J. Biol. Chem. United States. 275 (15): 11114—20. ISSN 0021-9258. PMID 10753917. doi:10.1074/jbc.275.15.11114.

[pmid18239673-12] а ^б Didelot C, Lanneau D, Brunet M, Bouchot A, Cartier J, Jacquel A, Ducoroy P, Cathelin S, Decologne N, Chiosis G, Dubrez-Daloz L, Solary E, Garrido C (2008). „Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation”. Cell Death Differ. England. 15 (5): 859—66. ISSN 1350-9047. PMID 18239673. doi:10.1038/cdd.2008.5.

[pmid18570872-13] а ^б Bertrand, Mathieu J M; Milutinovic Snezana; et al. (2008). „cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination”. Mol. Cell. United States. 30 (6): 689—700. PMID 18570872. doi:10.1016/j.molcel.2008.05.014.

[pmid9545235-14] Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC (1998). „IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases”. EMBO J. ENGLAND. 17 (8): 2215—23. ISSN 0261-4189. PMC 1170566 . PMID 9545235. doi:10.1093/emboj/17.8.2215.

[pmid12571250-15] Kuai, June; Nickbarg Elliott; et al. (2003). „Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis”. J. Biol. Chem. United States. 278 (16): 14363—9. ISSN 0021-9258. PMID 12571250. doi:10.1074/jbc.M208672200.

[pmid9642260-16] McCarthy JV, Ni J, Dixit VM (1998). „RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase”. J. Biol. Chem. United States. 273 (27): 16968—75. ISSN 0021-9258. PMID 9642260. doi:10.1074/jbc.273.27.16968.

[pmid9705938-17] Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (1998). „Identification of CARDIAK, a RIP-like kinase that associates with caspase-1”. Curr. Biol. ENGLAND. 8 (15): 885—8. ISSN 0960-9822. PMID 9705938. doi:10.1016/S0960-9822(07)00352-1.

[pmid18230607-18] Sekine, Keiko; Takubo Kohei; et al. (2008). „Small molecules destabilize cIAP1 by activating auto-ubiquitylation”. J. Biol. Chem. United States. 283 (14): 8961—8. ISSN 0021-9258. PMID 18230607. doi:10.1074/jbc.M709525200.

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