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Gama glutamil transferaza 2
Identifikatori
Simbol	GGT2
Alt. simboli	GGT
Entrez	2679
Hugo	4251
OMIM	137181
RefSek	NM_002058
UniProt	P36268
Drugi podaci
EC broj	2.3.2.2
Lokus	Hrom. 22 q11.1-11.2

Gama glutamil transferaza 1
Identifikatori
Simbol	GGT1
Alt. simboli	GGT
Entrez	2678
Hugo	4250
OMIM	231950
RefSek	NM_001032364
UniProt	P19440
Drugi podaci
EC broj	2.3.2.2
Lokus	Hrom. 22 q11.1-11.2

Gama glutamil transferaza
Identifikatori
EC broj	2.3.2.2
CAS broj	9046-27-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Ontologija gena	AmiGO / EGO
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Ne treba izjednačavati sa GGGT-om.

Gama glutamil transferaza (GGT) ili gama glutamil transpeptidaza (GGTP), takođe γ-glutamiltransferaza, gama-GT, (EC 2.3.2.2), je membranski enzim iz grupe peptidaza koji katalizuje prenos hidrolizom oslobođenog ostatka glutaminske kiseline na neku aminokiselinu ili peptid.^[1]^[2] Takođe je uključen u metabolizam glutationa.^[3] U organizmu se javlja pretežno vezan na ćelijske membrane. Najviše gama glutamil transferaze ima u bubrezima, prostati, jetri, epitelu tankog creva i mozgu, nalazi se na mestima intenzivne apsorpcije aminokiselina. GGT je veoma osetljiv indikator za oboljenja jetre, mada je prisutan i u pankreasu i bubrezima.^[4]

Porast katalitičke aktivnosti GGT u serumu je najosetljiviji pokazatelj oštećenja jetre, a naročito je izražen ako su oštećenja uzrokovana alkoholom. Dobar je pokazatelj u diferencijalnoj dijagnostici hepatocelularne i opstruktivne žutice.

Aktivnost je povišena kod ciroze jetre^[5], akutnog virusnog hepatitisa, hroničnog hepatitisa, pankreatitisa, infarkta miokarda, postojanja opstrukcije (prepreke) u žučnim putevima, primarnih ili metastatskih tumora jetre, oštećenja jetre izazvanog alkoholizmom, dekompenzovane srčane bolesti i zloćudnog tumora pankreasa.

Budući da se povišen nivo GGT nalazi kod bolesnika sa alkoholnom cirozom jetre i kod ljudi koji su teški alkoholičari, GGT je značajan u otkrivanju alkoholizma, alkoholnih oštećenja jetre i praćenju alkoholne apstinencije.

Snižene vrednosti nisu klinički značajne.

Reference

↑ „Povišena gama glutamil transferaza (GGT)”. Pristupljeno 18. 8. 2010. na osnovu dozvole
↑ Meister A (August 1974). „The gamma-glutamyl cycle. Diseases associated with specific enzyme deficiencies”. Ann. Intern. Med. 81 (2): 247–53. PMID 4152527.
↑ Raulf M, Stüning M, König W (May 1985). „Metabolism of leukotrienes by L-gamma-glutamyl-transpeptidase and dipeptidase from human polymorphonuclear granulocytes”. Immunology 55 (1): 135–47. PMC 1453575. PMID 2860060.
↑ Goldberg, DM (1980). „Structural, functional, and clinical aspects of gamma-glutamyltransferase”. Crit Rev Clin Lab Sci 12 (1): 1–58. DOI:10.3109/10408368009108725. PMID 6104563.
↑ Kaplan, MM; et al (1985). Chang, NC; Chan, NM. ur. Biochemical basis for serum enzyme abnormalities in alcoholic liver disease. NIAAA. str. 186.

Literatura

Yokoyama H (June 2007). „[Gamma glutamyl transpeptidase (gammaGTP) in the era of metabolic syndrome]” (Japanese). Nihon Arukoru Yakubutsu Igakkai Zasshi 42 (3): 110–24. PMID 17665541.
Schulman JD, Goodman SI, Mace JW, Patrick AD, Tietze F, Butler EJ (July 1975). „Glutathionuria: inborn error of metabolism due to tissue deficiency of gamma-glutamyl transpeptidase”. Biochem. Biophys. Res. Commun. 65 (1): 68–74. DOI:10.1016/S0006-291X(75)80062-3. PMID 238530.
Lum G, Gambino SR (April 1972). „Serum gamma-glutamyl transpeptidase activity as an indicator of disease of liver, pancreas, or bone”. Clin. Chem. 18 (4): 358–62. PMID 5012259.
Betro MG, Oon RC, Edwards JB (November 1973). „Gamma-glutamyl transpeptidase in diseases of the liver and bone”. Am. J. Clin. Pathol. 60 (5): 672–8. PMID 4148049.
Rosalki SB, Tarlow D, Rau D (August 1971). „Plasma gamma-glutamyl transpeptidase elevation in patients receiving enzyme-inducing drugs”. Lancet 2 (7720): 376–7. PMID 4105075.
Barouki R; Chobert MN; Finidori J; Aggerbeck M; Nalpas B; Hanoune J (May 1983). „Ethanol effects in a rat hepatoma cell line: induction of gamma-glutamyltransferase”. Hepatology 3 (3): 323–9. DOI:10.1002/hep.1840030308. PMID 6132864.
Lamy, J; Baglin, MC; Ferrant, JP; Weill, J (1974). „Determination de la gamma-glutamyl transpeptidase senque des ethyliques a la suite du sevrage”. Clin Chim Acta 56: 169.
Ruttmann, E; Brant, L; Concin, H; Diem, G (2005). „Gamma-Glutamyltransferase as a Risk Factor for Cardiovascular Disease Mortality”. Epidemiology 112: 2130-2137. Arhivirano iz originala na datum 2011-06-08. Pristupljeno 2014-05-20.
Ruttmann, E; Brant, L; Concin, H; Diem, G; Rapp, K; Ulmer, H; Vorarlberg Health Monitoring and Promotion Program Study Group (2005). „Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrian adults”. Circulation 112 (14): 2130-2137. DOI:10.1161/CIRCULATIONAHA.105.552547. PMID 16186419. Arhivirano iz originala na datum 2011-06-08. Pristupljeno 2014-05-20.
Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Vanjske veze

MeSH gamma-Glutamyltransferase

[1] „Povišena gama glutamil transferaza (GGT)”. Pristupljeno 18. 8. 2010. na osnovu dozvole

[meister-2] Meister A (August 1974). „The gamma-glutamyl cycle. Diseases associated with specific enzyme deficiencies”. Ann. Intern. Med. 81 (2): 247–53. PMID 4152527.

[pmid2860060-3] Raulf M, Stüning M, König W (May 1985). „Metabolism of leukotrienes by L-gamma-glutamyl-transpeptidase and dipeptidase from human polymorphonuclear granulocytes”. Immunology 55 (1): 135–47. PMC 1453575. PMID 2860060.

[goldberg-4] Goldberg, DM (1980). „Structural, functional, and clinical aspects of gamma-glutamyltransferase”. Crit Rev Clin Lab Sci 12 (1): 1–58. DOI:10.3109/10408368009108725. PMID 6104563.

[kaplan-5] Kaplan, MM; et al (1985). Chang, NC; Chan, NM. ur. Biochemical basis for serum enzyme abnormalities in alcoholic liver disease. NIAAA. str. 186.

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[2]

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[5]

Gama-glutamiltransferaza

Reference

Literatura

Vanjske veze