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Glicerol-3-fosfat O-aciltransferaza
Identifikatori
EC broj	2.3.1.15
CAS broj	9029-96-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Glicerol-3-fosfat O-aciltransferaza (EC 2.3.1.15, alfa-glicerofosfatna aciltransferaza, 3-glicerofosfatna aciltransferaza, ACP:sn-glicerol-3-fosfatna aciltransferaza, glicerol 3-fosfatna aciltransferaza, glicerol fosfatna aciltransferaza, glicerol fosfatna transacilaza, glicerofosfatna aciltransferaza, glicerofosfatna transacilaza, sn-glicerol 3-fosfatna aciltransferaza, sn-glicerol-3-fosfatna aciltransferaza, glicerol-3-fosfatna O-aciltransferaza) je enzim sa sistematskim imenom acil-KoA:sn-glicerol-3-fosfat 1-O-aciltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

acil-KoA + sn-glicerol 3-fosfat

\rightleftharpoons

KoA + 1-acil-sn-glicerol 3-fosfat

Acil-[acil-nosilac protein] takođe može da deluje kao acil donor.

Reference

↑ Bertrams, M. and Heinz, E. (1981). „Positional specificity and fatty-acid selectivity of purified sn-glycerol 3-phosphate acyltransferases from chloroplasts”. Plant Physiol. 68: 653-657. PMID 16661974.
↑ Frentzen, M., Heinz, E., McKeon, T.A. and Stumpf, P.K. (1983). „Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts”. Eur. J. Biochem. 129: 629-636. PMID 6825679.
↑ Green, P.R., Merrill, A.H. and Bell, R.M. (1981). „Membrane phospholipid synthesis in Escherichia coli. Purification, reconstitution, and characterization of sn-glycerol-3-phosphate acyltransferase”. J. Biol. Chem. 256: 11151-11159. PMID 6350296.
↑ Yamashita, S. and Numa, N. (1972). „Partial purification and properties of glycerophosphate acyltransferase from rat liver. Formation of 1-acylglycerol 3-phosphate from sn-glycerol 3-phosphate and palmityl coenzyme A”. Eur. J. Biochem. 31: 565-573. PMID 4650158.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Glycerol-3-phosphate+1-O-acyltransferase

[1] Bertrams, M. and Heinz, E. (1981). „Positional specificity and fatty-acid selectivity of purified sn-glycerol 3-phosphate acyltransferases from chloroplasts”. Plant Physiol. 68: 653-657. PMID 16661974.

[2] Frentzen, M., Heinz, E., McKeon, T.A. and Stumpf, P.K. (1983). „Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts”. Eur. J. Biochem. 129: 629-636. PMID 6825679.

[3] Green, P.R., Merrill, A.H. and Bell, R.M. (1981). „Membrane phospholipid synthesis in Escherichia coli. Purification, reconstitution, and characterization of sn-glycerol-3-phosphate acyltransferase”. J. Biol. Chem. 256: 11151-11159. PMID 6350296.

[4] Yamashita, S. and Numa, N. (1972). „Partial purification and properties of glycerophosphate acyltransferase from rat liver. Formation of 1-acylglycerol 3-phosphate from sn-glycerol 3-phosphate and palmityl coenzyme A”. Eur. J. Biochem. 31: 565-573. PMID 4650158.

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