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Karnitin O-palmitoiltransferaza
Identifikatori
EC broj	2.3.1.21
CAS broj	9068-41-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Karnitin O-palmitoiltransferaza (EC 2.3.1.21, CPT, CPTo, spoljašna malonil-KoA inhibitabilna karnitinska palmitoiltransferaza, CPTi, CPT I (spoljašnja membranska karnitin palmitoilna transferaza), karnitinska palmitoiltransferaza I, karnitinska palmitoiltransferaza II, CPT-A, CPT-B, acilkarnitinska transferaza, karnitinska palmitoiltransferaza, karnitinska palmitoiltransferaza-A, L-karnitinska palmitoiltransferaza, palmitoilkarnitinska transferaza) je enzim sa sistematskim imenom palmitoil-KoA:L-karnitin O-palmitoiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

palmitoil-KoA + L-karnitin

\rightleftharpoons

KoA + L-palmitoilkarnitin

Ovaj enzim ima široku specifičnost za acil grupe, u opsegu C8 do C18. Optimalni supstrat je palmitoil-KoA.

Reference

↑ Derrick, J.P., Tubbs, P.K. and Ramsay, R.R. (1986). „Purification and properties of an easily solubilized L-carnitine palmitoyltransferase from beef-liver mitochondria”. Biochem. Soc. Trans. 14: 698-698.
↑ Healy, M.J., Kerner, J. and Bieber, L.L. (1988). „Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?”. Biochem. J. 249: 231-237. PMID 3342008.
↑ Miyazawa, S., Ozasa, H., Osumi, T. and Hashimoto, T. (1983). „Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver”. J. Biochem. (Tokyo) 94: 529-542. PMID 6630173.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Carnitine+O-palmitoyltransferase

[1] Derrick, J.P., Tubbs, P.K. and Ramsay, R.R. (1986). „Purification and properties of an easily solubilized L-carnitine palmitoyltransferase from beef-liver mitochondria”. Biochem. Soc. Trans. 14: 698-698.

[2] Healy, M.J., Kerner, J. and Bieber, L.L. (1988). „Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?”. Biochem. J. 249: 231-237. PMID 3342008.

[3] Miyazawa, S., Ozasa, H., Osumi, T. and Hashimoto, T. (1983). „Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver”. J. Biochem. (Tokyo) 94: 529-542. PMID 6630173.

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