Propranolol

Propranolol
enancjomer R (na górze) i S (na dole)
Ogólne informacje
Wzór sumaryczny

C16H21NO2

Masa molowa

259,34 g/mol

Wygląd

ciało stałe

Identyfikacja
Numer CAS

525-66-6

PubChem

4946

DrugBank

DB00571

Jeżeli nie podano inaczej, dane dotyczą
stanu standardowego (25 °C, 1000 hPa)
Klasyfikacja medyczna
ATC

C07AA05, C07BA05, C07FX01

Stosowanie w ciąży

kategoria C

Propranololorganiczny związek chemiczny, wielofunkcyjna pochodna naftalenu. Nieselektywny lek β-adrenolityczny (β-bloker), bez wewnętrznej aktywności sympatykomimetycznej, mający działanie stabilizujące błonę komórkową. Blokuje działanie amin katecholowych (a konkretnie adrenaliny i noradrenaliny) na serce, powodując spadek zapotrzebowania serca na tlen oraz zwolnienie częstości jego pracy i w konsekwencji spadek ciśnienia tętniczego (zwłaszcza skurczowego). Ze względu na blokowanie również receptorów B-2 propranolol powoduje obkurczenie naczyń, a tym samym szybszy zanik naczyniaków[3].

Wskazania

Przeciwwskazania

Działania niepożądane

Mogą mieć większe nasilenie przy stosowaniu wyższych dawek.

Z uwagi na wywoływanie niekorzystnych zmian w składzie lipidów jest stopniowo wypierany w kardiologii przez nowsze odmiany beta-adrenolityków (beta blokerów).

Przypisy

  1. a b c d e Propranolol, [w:] DrugBank [online], University of Alberta, DB00571 (ang.).
  2. James W. McFarland i inni, Estimating the Water Solubilities of Crystalline Compounds from Their Chemical Structures Alone, „Journal of Chemical Information and Computer Sciences”, 41 (5), 2001, s. 1355–1359, DOI10.1021/ci0102822 (ang.).
  3. Yasaman R. Shayan, Julie S. Prendiville, Ran D. Goldman, Use of propranolol in treating hemangiomas, „Canadian Family Physician Medecin De Famille Canadien”, 57 (3), 2011, s. 302–303, PMID21402965, PMCIDPMC3056677 (ang.).
  4. Fred Michael Cutrer, Headaches Associated with Exertion and Sexual Activity [online], American Headache Society (ang.).
  5. Akatyzja – neurologiczne.pl [online], www.neurologiczne.pl [dostęp 2017-09-09].

Bibliografia

  • Indeks leków Medycyny Praktycznej 2006, Kraków, Wydawnictwo Medycyna Praktyczna, ISBN 83-7430-060-4.
  • Małgorzata Rzewuska, Leczenie zaburzeń psychicznych, t. 3, Warszawa: PZWL, 2006, ISBN 83-200-3354-3.

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