3-하이드록시뷰티르산 탈수소효소

3-하이드록시뷰티르산 탈수소효소
식별자
EC 번호1.1.1.30
CAS 번호9028-38-0
데이터베이스
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB 구조RCSB PDB PDBj PDBe PDBsum
유전자 온톨로지AmiGO / QuickGO

3-하이드록시뷰티르산 탈수소효소(영어: 3-hydroxybutyrate dehydrogenase) (EC 1.1.1.30)는 다음과 같은 화학 반응을 촉매하는 효소이다.

(R)-3-하이드록시뷰티르산 + NAD+ ⇄ 아세토아세트산 + NADH + H+

3-하이드록시뷰티르산 탈수소효소의 2가지 기질은 (R)-3-하이드록시뷰티르산, NAD+이며, 3가지 생성물은 아세토아세트산, NADH, H+이다. 3-하이드록시뷰티르산 탈수소효소는 산화환원효소 부류에 속하며, 특히 공여체가 CH-OH기이며, 수용체가 NAD+ 또는 NADP+인 효소에 속한다.

3-하이드록시뷰티르산 탈수소효소는 케톤체의 합성과 분해, 뷰티르산의 대사에 참여한다.

명명법

3-하이드록시뷰티르산 탈수소효소의 계통명은 (R)-3-하이드록시뷰탄산:NAD+ 산화환원효소(영어: (R)-3-hydroxybutanoate:NAD+ oxidoreductase)이다.

다음은 일반적으로 사용되는 다른 이름들이다.

  • NAD+-β-하이드록시뷰티르산 탈수소효소(영어: NAD+-β-hydroxybutyrate dehydrogenase)
  • 하이드록시뷰티르산 산화환원효소(영어: hydroxybutyrate oxidoreductase)
  • β-하이드록시뷰티르산 탈수소효소(영어: β-hydroxybutyrate dehydrogenase)
  • D-β-하이드록시뷰티르산 탈수소효소(영어: D-β-hydroxybutyrate dehydrogenase)
  • D-3-하이드록시뷰티르산 탈수소효소(영어: D-3-hydroxybutyrate dehydrogenase)
  • D-(–)-3-하이드록시뷰티르산 탈수소효소(영어: D-(–)-3-hydroxybutyrate dehydrogenase)
  • β-하이드록시뷰티르산 탈수소효소(영어: β-hydroxybutyric acid dehydrogenase)
  • 3-D-하이드록시뷰티르산 탈수소효소(영어: 3-D-hydroxybutyrate dehydrogenase)
  • β-하이드록시뷰티릭 탈수소효소(영어: β-hydroxybutyric dehydrogenase)

구조 연구

2007년을 기준으로 이러한 부류의 효소에 대해 PDB 접근 코드 1WMB, 1X1T의 2가지 구조가 해결되었다.

같이 보기

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