Mexiletina

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Mexiletina
Caratteristiche generali
Formula bruta o molecolareC11H17NO
Massa molecolare (u)179.259 g/mol
Numero CAS31828-71-4
Numero EINECS250-825-7
Codice ATCC01BB02
PubChem3356
DrugBankDBDB00379
SMILES
CC1=C(C(=CC=C1)C)OCC(C)N
Dati farmacologici
Modalità di
somministrazione		Orale - Intravenosa
Dati farmacocinetici
Emivita10-12 ore circa
Indicazioni di sicurezza
Simboli di rischio chimico
irritante
attenzione
Frasi H302
Consigli P---[1]
Modifica dati su Wikidata · Manuale

La mexiletina è un antiaritmico, un principio attivo di indicazione specifica contro le anomalie del ritmo cardiaco (aritmie) Rientra nella classe IB. Provoca un decremento della frequenza dei potenziali d'azione allungando la fase di ripolarizzazione, attraverso il blocco dei canali per il sodio[2].

Indicazioni

Viene utilizzato come terapia contro aritmie ventricolari.

Controindicazioni

Controindicato in caso di shock cardiogeno, blocco atrioventricolare (2-3º grado)

Effetti indesiderati

Fra gli effetti collaterali più frequenti si riscontrano vomito, dispepsia, nausea, ipotensione, diarrea, bradicardia, insonnia, sonnolenza.

Note

  1. ^ Sigma Aldrich; rev. del 05.10.2012, riferita al cloridrato
  2. ^ Mexiletine, RxList.com

Bibliografia

  • British national formulary, Guida all’uso dei farmaci 4 edizione, Lavis, agenzia italiana del farmaco, 2007.
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