Bezitramid

Bezitramid
IUPAC-név
2,2-difenil-4-[4-(2-oxo-3-propanoil-2,3-dihidro-1H-benzimidazol-1-il)piperidin-1-il]butánnitril
Kémiai azonosítók
CAS-szám 15301-48-1
PubChem 61791
ChemSpider 55675
DrugBank DB01459
ATC kód N02AC05
Gyógyszer szabadnév bezitramide
SMILES
O=C(N2c1ccccc1N(C2=O) C5CCN(CCC(C#N)(c3ccccc3)c4ccccc4)CC5)CC
InChI
1/C31H32N4O2/c1-2-29(36)35-28-16-10-9-15-27(28) 34(30(35)37)26-17-20-33(21-18-26) 22-19-31(23-32,24-11-5-3-6-12-24) 25-13-7-4-8-14-25/ h3-16,26H,2,17-22H2,1H3
InChIKey FLKWNFFCSSJANB-UHFFFAOYSA-N
UNII 3KXW0Y310I
Kémiai és fizikai tulajdonságok
Kémiai képlet C31H32N4O2
Moláris tömeg 492,61 g/mol
Sűrűség 1,217
Olvadáspont 145–149 °C [1]
Forráspont 670,6 °C
Terápiás előírások
Alkalmazás orális

A bezitramid szájon át adható opioid típusú fájdalomcsillapító. Komoly fájdalom ellen adják. A felfutása lassú, de a hatása hosszú ideig tart. Az emésztőrendszerben dezpropionil-bezitramiddá hidrolizál, mely farmakológialiag ugyanolyan hatású, mint az eredeti bezitramid.

Az Európai Unióban kábítószernek minősül.[2]

Fizikai tulajdonságok

Fehér, amorf vagy kristályos por. Vízben és alkoholban gyakorlatilag nem, éterben 1:400, acetonban 1:45, kloroformban 1:2 arányban oldódik.

Készítmények

Nemzetközi forgalomban[3]

  • Burgodin

Magyarországon nincs forgalomban.[4]

Jegyzetek

  1. ↑ Bezitramide[halott link] (ChemIDplus Advanced)
  2. ↑ Magyarországon a 66/2012. (IV. 2.) Korm. rendelet[halott link] értelmében.
  3. ↑ Bezitramide (Drugs-About.com)
  4. ↑ Bezitramide[halott link] (OGYI)

Források

Fizikai/kémiai tulajdonságok

További információk

Read other articles:

Kucing kashmir

Artikel ini bukan mengenai Kucing kasymir. Kashmir Asal  Amerika Serikat Kucing domestik (Felis catus) Kucing kashmir adalah salah satu ras kucing domestik yang berasal dari Amerika Serikat.[1] Referensi ^ (Indonesia) Tabel Jenis/Ras Kucing Populer. www.kucing.biz. Diakses 6 September 2014. lbs Kucing domestikFelinologi Anak kucing Anatomi kucing Genetika kucing Indera kucing Kucing bermata ganjil Kucing kerdil Kucing polidaktil Kucing tupai Mutasi genetik Genetika bulu Kucing be...

 

Pramuka Siaga Tata

Siaga Tata adalah tingkatan ketiga atau terakhir dalam Syarat-syarat Kecakapan Umum satuan Pramuka Siaga. setelah Siaga Mula dan Siaga Bantu. Pramuka Siaga yang telah menyelesaikan SKU Siaga Tata dapat mengikuti Pramuka Garuda untuk golongan Pramuka Siaga. Syarat-syarat yang harus dipenuhi Untuk mencapai tingkat Siaga Tata, seorang Pramuka Siaga Bantu harus memenuhi syarat-syarat sebagai berikut: Rajin dan giat mengikuti latihan Perindukan sebagai Siaga Bantu, sekurang-kurangnya 10 kali lati...

 

Jab Jab Phool Khile

For the Pakistani film, see Jab Jab Phool Khile (1975 film). 1965 Indian filmJab Jab Phool KhileFilm posterDirected bySuraj Prakash (director) Written byBrij KatyalProduced byChetan KStarringShashi KapoorNandaAghaCinematographyTaru DuttEdited byStanley JoshuaSuraj PrakashMusic byKalyanji-AnandjiProductioncompanyLime LightRelease date 5 November 1965 (1965-11-05) Running time141 minutesCountryIndiaLanguageHindiBox office₹5.5 crore (equivalent to ₹367 crore or US...

Shahid Sadr Metro Station

Station of the Tehran Metro Sadrایستگاه مترو صدرGeneral informationLocation Shariati Street- Sadr ExpresswayDistrict 1, Tehran, ShemiranatIranCoordinates35°47′07″N 51°26′09″E / 35.78528°N 51.43583°E / 35.78528; 51.43583Operated byTehran Urban and Suburban Railways Organization (Metro)Connections Tehran Buses 225 Dastvareh Term.-Qods Sq.303 Pich-e Shemiran-Qods Sq.357 Emam Khomeini Metro-Qods Sq.387 Qods Sq.-Resalat Sq. HistoryOpened1389 H-Sh (...

 

Guerre polono-russe (1605-1618)

Cet article est une ébauche concernant l’histoire, la Russie et la Pologne. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Si ce bandeau n'est plus pertinent, retirez-le. Cliquez ici pour en savoir plus. Cet article ne cite pas suffisamment ses sources (août 2015). Si vous disposez d'ouvrages ou d'articles de référence ou si vous connaissez des sites web de qualité traitant du thème abordé ici, merci d...

 

Millions (lagu Winner)

MillionsSingel oleh WinnerDirilis19 Desember 2018 (2018-12-19)GenreDansapopDurasi3:29LabelYGGenie MusicKomponis musikYoonKang Uk-jinDiggyLirikusYoonMinoHoonyKronologi singel Winner Everyday (2018) Millions (2018) Ah Yeah (2019) Video musikMillions di YouTube Millions adalah lagu yang direkam oleh grup pria Winner asal Korea Selatan. Lagu ini dirilis pada 19 Desember 2018 di bawah label YG Entertainment dan didistribusikan oleh Genie Music.[1][2] Latar belakang dan perilis...

Arsitektur Utsmaniyah

Masjid Biru di Istanbul, salah satu Situs Warisan Dunia dan contoh dari periode klasik arsitektur Utsmaniyah dengan pengaruh Bizantium. BudayaKesultanan Utsmaniyah Seni rupa visual Arsitektur Miniatur Tembikar Kaligrafi Seni rupa petunjukan Permainan panggung bayangan Meddah Tarian Musik Bahasa dan sastra Turki Utsmaniyah Puisi Prosa Olahraga Gulat minyak Panahan Cirit Lain-lain Masakan Karpet Busana lbs Bagian dari seri tentangBudaya Turki Sejarah Mitologi dan cerita rakyat Cerita rakyat Hid...

 

Speaker of the House of Representatives (Japan)

This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Speaker of the House of Representatives Japan – news · newspapers · books · scholar · JSTOR (August 20...

 

Santuario di Santa Augusta

Questa voce o sezione sull'argomento chiese del Veneto non cita le fonti necessarie o quelle presenti sono insufficienti. Puoi migliorare questa voce aggiungendo citazioni da fonti attendibili secondo le linee guida sull'uso delle fonti. Santuario di Santa AugustaVeduta del santuario da Sant'Andrea di BigonzoStato Italia RegioneVeneto LocalitàVittorio Veneto Coordinate46°00′11.85″N 12°17′31.95″E / 46.003291°N 12.292208°E46.003291; 12.292208Coordinate: 4...

القاسم بن معن

القاسم بن معن معلومات شخصية تاريخ الوفاة سنة 791   الكنية أبو عبد الله الحياة العملية المهنة كاتب،  ولغوي،  وراوي حديث،  وأديب  تعديل مصدري - تعديل   القاسم بن معن (…- 175 هـ = …- 791 م)،[1] هو أديب ولغوي وراوية ومُحدِّث من الكوفة، عاش في القرن الثاني الهجري. سيرته...

 

Eleições estaduais no Rio de Janeiro em 2010

← 2006  2014 → Eleições estaduais no  Rio de Janeiro em 2010 3 de outubro de 2010(Decisão em primeiro turno) Candidato Sérgio Cabral Filho Fernando Gabeira Fernando Peregrino Partido PMDB PV PR Natural de Rio de Janeiro, RJ Juiz de Fora, MG Belém, PA Vice Luiz Fernando Pezão Márcio Fortes David Cabral Votos 5.217.972 1.632.671 853.220 Porcentagem 66,08% 20,68% 10,81% Candidato mais votado por município no 1º turno (92):  Sergio Cabral (92) Governador do ...

 

Trichothecene

Large family of chemically related mycotoxins This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Trichothecene – news · newspapers · books · scholar · JSTOR (October 2008) (Learn how and when to remove this message) Chemical structure of trichothecenes The trichothecenes are a large family of chemically related...

List of Venus-crossing minor planets

Outer-grazer: middle column, bottom;Crosser: right column, bottom A Venus-crosser is an asteroid whose orbit crosses that of Venus. There are 2,809[1] Venus-crosser and 98 outer-grazers known.[2] Mercury-crossers or grazers are marked ‡. Venus also has a quasi-satellite, 524522 Zoozve. This asteroid is also a Mercury- and Earth-crosser; it seems to have been a companion to Venus for the last 7,000 years or so only, and is destined to be ejected from this orbital arrangement...

 

قالب:نسوية

عنتنسويةتاريخعام الموجة الأولى الموجة الثانية الموجة الثالثة الموجة الرابعة اجتماعي قيادة الدراجات تاريخ الحركة النسوية تاريخ المرأة الجدول الزمني للحقوق القانونية للمرأة (بخلاف التصويت) حق التصويت أستراليا كندا اليابان الكويت نيوزيلاندا سويسرا المملكة المتحدة ويلز ا...

 

William Thurston

William Thurston nel 1991 Medaglia Fields nel 1982 William Paul Thurston (Washington, 30 ottobre 1946 – Rochester, 21 agosto 2012) è stato un matematico statunitense. Vincitore della Medaglia Fields per i suoi contributi nella topologia della dimensione bassa, è stato professore alla Cornell University dal 2003 al 2012. È morto nel 2012, all'età di 65 anni[1], a causa di un melanoma che gli era stato diagnosticato l'anno precedente. Indice 1 Contributi 2 Note 3 Bibliografia 4 Vo...

Pavel Savicki

Questa voce sull'argomento calciatori bielorussi è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Pavel SavickiNazionalità Bielorussia Altezza175 cm Peso69 kg Calcio RuoloAttaccante Squadra Nëman CarrieraSquadre di club1 2010-2014 Nëman99 (22)2015→  Jagiellonia5 (0)2015-2017 Nëman63 (26)2018-2020 Dinamo Brėst75 (33)2021 Ruch Brėst26 (4)2022- Nëman16 (7) N...

 

James Whittico Jr.

American physician James Whittico Jr.Born(1915-11-18)November 18, 1915Williamson, West Virginia, U.S.DiedAugust 21, 2018(2018-08-21) (aged 102)Allegiance United StatesService/branch United States ArmyRank Lieutenant colonelBattles/wars World War II Bronze Star James Whittico Jr. (November 18, 1915 – August 21, 2018) was an American physician from St. Louis, Missouri. He was the first African American named a full clinical professor at any medical school in St. Louis and was t...

 

Инкское право

Инкское право или Законы Инков — правовая система, возникшая на основе Андских культур и развивавшаяся вплоть до падения Империи Инков в 1533 году, затем в Новоинкском государстве в Вилькабамбе до 1572 года, и просуществовавшая несколько десятилетий[1] (а в отдельных �...

Abnormal psychology

Branch of psychology Part of a series onPsychology Outline History Subfields Basic psychology Abnormal Affective neuroscience Affective science Behavioral genetics Behavioral neuroscience Behaviorism Cognitive/Cognitivism Cognitive neuroscience Social Comparative Cross-cultural Cultural Developmental Differential Ecological Evolutionary Experimental Gestalt Intelligence Mathematical Moral Neuropsychology Perception Personality Psycholinguistics Psychophysiology Quantitative Social Theoretical...

 

Prime Minister of Poland

Head of government of Poland For a list of holders of the office, see List of prime ministers of Poland. President of theCouncil of MinistersPrezes Rady Ministrów (Polish)Logo used by institutions of thePolish GovernmentFlag of PolandIncumbentDonald Tusksince 13 December 2023Council of MinistersChancellery of the Prime MinisterStyleMr Prime Minister (informal)His Excellency (diplomatic)TypeHead of governmentMember ofEuropean CouncilResidenceHotel Parkowa, Warsaw (official, rarely o...