25I-NBMD

25I-NBMD
Tunnisteet
IUPAC-nimi 2-(4-jodi-2,5-dimetoksifenyyli)-N-[(2,3-metyleenidioksifenyyli)metyyli]etanamiini
CAS-numero 919797-25-4
PubChem CID 57507899
Ominaisuudet
Molekyylikaava C18H20INO<sub4
Moolimassa 441,259 g/mol

25I-NBMD on psykedeelisestä fenetyyliamiinista2C-I:stä – johdettu muuntohuume. Kemikaalin löysi farmakologi David Nicholsin johtama tutkijaryhmä Purduen yliopistossa vuonna 2006.

Kemikaali toimii voimakkaana 5HT2A-reseptorin osittaisagonistinia.[1][2][3] Sen annostukseksi on raportoitu yleensä 500–1 500 mikrogrammaa. 25I-NBMD:n uskotaan olevan aktiivinen 500 mikrogramman annoksilla, vaikka joidenkin lähteiden mukaan 1 500–2 000 mikrogrammaa on kerrottu olevan vielä alhainen annos. Näin ollen se on annosmääriin nähden neljä kertaa miedompi kuin sille sukua oleva 25I-NBOMe.lähde?

25I-NBMD:tä ei ole esiintynyt huumausainekaupassa pitkään, joten sen käytöstä on vain vähän tietoa, ja vain muutamia käyttökertoja on raportoitu.

25I-NBMD on luokiteltu Suomessa kuluttajamarkkinoilta kielletyksi psykoaktiiviseksi aineeksi.[4]

Katso myös

Lähteet

  1. Braden, MR; Parrish, JC; Naylor, JC; Nichols, DE: Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Molecular Pharmacology, 2006, 70. vsk, nro 6, s. 1956–64. PubMed:17000863 doi:10.1124/mol.106.028720
  2. Towards a biophysical understanding of hallucinogen action - ProQuest search.proquest.com. Viitattu 8.12.2017.
  3. Ettrup, A.; Hansen, M.; Santini, M. A.; Paine, J.; Gillings, N.; Palner, M.; Lehel, S.; Herth, M. M.; Madsen, J.: Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers. European Journal of Nuclear Medicine and Molecular Imaging, 2010, 38. vsk, nro 4, s. 681–93. PubMed:21174090 doi:10.1007/s00259-010-1686-8
  4. Valtioneuvoston asetus kuluttajamarkkinoilta kielletyistä psykoaktiivisista aineista finlex.fi. Viitattu 9.12.2017.

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